The underestimated role of the microphthalmia-associated transcription factor (MiTF) in normal and pathological haematopoiesis [PDF]
Cell & Bioscience, 2021 Haematopoiesis, the process by which a restrained population of stem cells terminally differentiates into specific types of blood cells, depends on the tightly regulated temporospatial activity of several transcription factors (TFs).
Alessia Oppezzo, Filippo Rosselli
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Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma [PDF]
Translational Oncology, 2019 Microphthalmia-associated transcription factor (MITF) is a key transcription factor in melanoma development and progression. MITF amplification and downregulation have been observed in a significant proportion of melanoma patients and correlate with ...
Gabriela M Wiedemann +10 more
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Mutation of microphthalmia-associated transcription factor (mitf) in zebrafish sensitizes for glomerulopathy [PDF]
Biology Open, 2019 Different glomerular diseases that affect podocyte homeostasis can clinically present as nephrotic syndrome with massive proteinuria, hypoalbuminemia, hyperlipidemia and edema.
Janina Müller-Deile +9 more
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Preclinical study of microphthalmia-associated transcription factor inhibitor ML329 in gastrointestinal stromal tumor growth [PDF]
Molecular Therapy: OncologyGastrointestinal stromal tumors (GISTs) comprise about 80% of mesenchymal neoplasms in the gastrointestinal tract. Although imatinib mesylate is the preferred treatment, the development of drug resistance highlights the need for novel therapeutic ...
Mario Guerrero +7 more
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Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells [PDF]
Journal for ImmunoTherapy of Cancer, 2023 Background Microphthalmia-associated transcription factor (MITF) is a master regulator of melanogenesis and is mainly expressed in melanoma cells. MITF has also been reported to be expressed in non-pigmented cells, such as osteoclasts, mast cells, and B ...
Yoon Kyung Jeon +8 more
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Characterizing the Coding Region Determinant-Binding Protein (CRD-BP)-Microphthalmia-associated Transcription Factor (MITF) mRNA interaction. [PDF]
PLoS ONE, 2017 Coding region determinant-binding protein (CRD-BP) binds to the 3'-UTR of microphthalmia-associated transcription factor (MITF) mRNA to prevent its targeted degradation by miR-340.
Gerrit van Rensburg +2 more
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Regulatory and Functional Connection of Microphthalmia-Associated Transcription Factor and Anti-Metastatic Pigment Epithelium Derived Factor in Melanoma [PDF]
Neoplasia: An International Journal for Oncology Research, 2014 Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor superfamily, has potent anti-metastatic effects in cutaneous melanoma through its direct actions on endothelial and melanoma cells.
Asunción Fernández-Barral +17 more
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C-KIT signaling depends on microphthalmia-associated transcription factor for effects on cell proliferation. [PDF]
PLoS ONE, 2011 The development of melanocytes is regulated by the tyrosine kinase receptor c-KIT and the basic-helix-loop-helix-leucine zipper transcription factor Mitf.
Bengt Phung +4 more
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Microphthalmia-Associated Transcription Factor: A Differentiation Marker in Uveal Melanoma [PDF]
International Journal of Molecular Sciences, 2023 Pieter van der Velden +2 more
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Antimelanogenic effect of ginsenoside Rg3 through extracellular signal-regulated kinase-mediated inhibition of microphthalmia-associated transcription factor [PDF]
Journal of Ginseng Research, 2015 Background: Panax ginseng has been used to prolong longevity and is believed to be useful for improving skin complexion. Ginsenosides are the most active components isolated from ginseng, and ginsenoside Rg3 (G-Rg3) in particular has been demonstrated to
Seung Jae Lee +3 more
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