Microphthalmia-Associated Transcription Factor: A Differentiation Marker in Uveal Melanoma [PDF]
International Journal of Molecular Sciences, 2023 Microphthalmia-associated transcription factor (MITF) is an important regulator of melanogenesis and melanocyte development. In cutaneous melanoma, MITF loss has been linked to an increased expression of stem cell markers, a shift in epithelial-to ...
Pieter Andries van der Velden +2 more
exaly +3 more sources
The underestimated role of the microphthalmia-associated transcription factor (MiTF) in normal and pathological haematopoiesis [PDF]
Cell & Bioscience, 2021 Haematopoiesis, the process by which a restrained population of stem cells terminally differentiates into specific types of blood cells, depends on the tightly regulated temporospatial activity of several transcription factors (TFs).
Alessia Oppezzo, Filippo Rosselli
doaj +3 more sources
Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells [PDF]
Journal for ImmunoTherapy of Cancer, 2023 Background Microphthalmia-associated transcription factor (MITF) is a master regulator of melanogenesis and is mainly expressed in melanoma cells. MITF has also been reported to be expressed in non-pigmented cells, such as osteoclasts, mast cells, and B ...
Yoon Kyung Jeon +8 more
doaj +3 more sources
Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma [PDF]
Translational Oncology, 2019 Microphthalmia-associated transcription factor (MITF) is a key transcription factor in melanoma development and progression. MITF amplification and downregulation have been observed in a significant proportion of melanoma patients and correlate with ...
Gabriela M Wiedemann +10 more
doaj +3 more sources
Mutation of microphthalmia-associated transcription factor (mitf) in zebrafish sensitizes for glomerulopathy [PDF]
Biology Open, 2019 Different glomerular diseases that affect podocyte homeostasis can clinically present as nephrotic syndrome with massive proteinuria, hypoalbuminemia, hyperlipidemia and edema.
Janina Müller-Deile +9 more
doaj +3 more sources
Antioxidant Graphene Oxide Nanoribbon as a Novel Whitening Agent Inhibits Microphthalmia-Associated Transcription Factor-Related Melanogenesis Mechanism [PDF]
ACS Omega, 2020 In the melanin synthesis process, oxidative reactions play an essential role, and it is a good strategy to inhibit melanin production by reducing oxidative stress.
Hsin-Yu Chou +6 more
doaj +3 more sources
Microphthalmia-Associated Transcription Factor in Melanoma Development and MAP-Kinase Pathway Targeted Therapy [PDF]
Pigment Cell and Melanoma Research, 2015 Malignant melanoma is a neoplasm of melanocytes, and the microphthalmia‐associated transcription factor (MITF) is essential for the existence of melanocytes.
Imanol Arozarena, Claudia Wellbrock
exaly +3 more sources
SH3BP2 Silencing Increases miRNAs Targeting ETV1 and Microphthalmia-Associated Transcription Factor, Decreasing the Proliferation of Gastrointestinal Stromal Tumors. [PDF]
Cancers (Basel), 2022 Simple Summary A previous study showed that silencing the adaptor molecule SH3 Binding Protein 2 (SH3BP2) reduced oncogenic KIT and PDGFRA receptor levels and impaired gastrointestinal stromal tumor (GIST) growth.
Proaño-Pérez E +5 more
europepmc +2 more sources
Mouse microphthalmia-associated transcription factor (Mitf) mutations affect the structure of the retinal vasculature. [PDF]
Acta Ophthalmol, 2022 Mice carrying pathogenic variants in the microphthalmia transcription factor (Mitf) gene show structural and functional changes in the retina and retinal pigment epithelium.
Daníelsson SB +3 more
europepmc +2 more sources
Antimelanogenic effect of ginsenoside Rg3 through extracellular signal-regulated kinase-mediated inhibition of microphthalmia-associated transcription factor [PDF]
Journal of Ginseng Research, 2015 Background: Panax ginseng has been used to prolong longevity and is believed to be useful for improving skin complexion. Ginsenosides are the most active components isolated from ginseng, and ginsenoside Rg3 (G-Rg3) in particular has been demonstrated to
Seung Jae Lee +3 more
doaj +3 more sources