Results 21 to 30 of about 9,717,047 (191)
Antioxidant Graphene Oxide Nanoribbon as a Novel Whitening Agent Inhibits Microphthalmia-Associated Transcription Factor-Related Melanogenesis Mechanism [PDF]
ACS Omega, 2020 Hsin-Yu Chou +6 more
doaj +2 more sources
Microphthalmia-Associated Transcription Factor in Senescence and Age-Related Diseases [PDF]
Gerontology, 2021 Although microphthalmia-associated transcription factor (MITF) has been known for decades as a key regulator for melanocytic differentiation, recent studies expanded its other roles in multiple biological processes. Among these newfound roles, the relationship between MITF and aging is attractive; however, the underlying mechanism remains elusive. Here,
Jian, Zhang +4 more
openaire +2 more sources
The roles of microphthalmia-associated transcription factor and pigmentation in melanoma. [PDF]
Arch Biochem Biophys, 2014 MITF and pigmentation play important roles in both normal melanocyte and transformed melanoma cell biology. MITF is regulated by many pathways and it also regulates many targets, some of which are still being discovered and functionally validated. MITF is involved in a wide range of processes in melanocytes, including pigment synthesis and lineage ...
Hsiao JJ, Fisher DE.
europepmc +4 more sources
Inhibitory Effects of Cycloheterophyllin on Melanin Synthesis
Molecules, 2021 This study was performed to clarify the inhibitory effects of cycloheterophyllin on melanin synthesis. In order to elucidate the inhibitory effects of cycloheterophyllin on the B16F10 cell line, cell viability, messenger ribonucleic acid (mRNA ...
Joong-Hyun Shim
doaj +1 more source
The Oncogene Transcription Factor EB Regulates Vascular Functions
Frontiers in Physiology, 2021 Transcription factor EB (TFEB) represents an emerging player in vascular biology. It belongs to the bHLH-leucine zipper transcription factor microphthalmia family, which includes microphthalmia-associated transcription factor, transcription factor E3 and
Gabriella Doronzo +5 more
doaj +1 more source
Negative Regulatory Loop between Microphthalmia-Associated Transcription Factor (MITF) and Notch Signaling. [PDF]
Int J Mol Sci, 2019 Melanoma, a melanocyte-origin neoplasm, is a highly metastatic and treatment-resistance cancer. While it is well established that notch signaling activation promotes melanoma progression, little is known about the reciprocal interactions between Notch ...
Golan T, Levy C.
europepmc +2 more sources
Cells, 2021 Fluoroquinolones cause phototoxic reactions, manifested as different types of skin lesions, including hyperpigmentation. The disturbances of melanogenesis indicate that fluoroquinolones may affect cellular processes in melanocytes.
Justyna Kowalska +5 more
doaj +1 more source
Plants, 2021 Melanogenesis represents a series of processes that produce melanin, a protective skin pigment (against ultraviolet rays), and determines human skin color. Chemicals reducing melanin production have always been in demand in the cosmetic market because of
Hwang-Ju Jeon +5 more
doaj +1 more source
Fraxinol Stimulates Melanogenesis in B16F10 Mouse Melanoma Cells through CREB/MITF Signaling
Molecules, 2022 Melanin pigment produced in melanocytes plays a protective role against ultraviolet radiation. Selective destruction of melanocytes causes chronic depigmentation conditions such as vitiligo, for which there are very few specific medical treatments. Here,
Sun Young Moon +7 more
doaj +1 more source
Microphthalmia-associated transcription factor suppresses invasion by reducing intracellular GTP pools. [PDF]
Oncogene, 2017 Melanoma progression is associated with increased invasion and, often, decreased levels of microphthalmia-associated transcription factor (MITF). Accordingly, downregulation of MITF induces invasion in melanoma cells; however, little is known about the underlying mechanisms. Here, we report for the first time that depletion of MITF results in elevation
Bianchi-Smiraglia A +17 more
europepmc +4 more sources