The roles of microphthalmia-associated transcription factor and pigmentation in melanoma. [PDF]
Arch Biochem Biophys, 2014 MITF and pigmentation play important roles in both normal melanocyte and transformed melanoma cell biology. MITF is regulated by many pathways and it also regulates many targets, some of which are still being discovered and functionally validated. MITF is involved in a wide range of processes in melanocytes, including pigment synthesis and lineage ...
Hsiao JJ, Fisher DE.
europepmc +4 more sources
Novel role of microphthalmia-associated transcription factor in modulating the differentiation and immunosuppressive functions of myeloid-derived suppressor cells [PDF]
Journal for ImmunoTherapy of Cancer, 2023 Background Microphthalmia-associated transcription factor (MITF) is a master regulator of melanogenesis and is mainly expressed in melanoma cells. MITF has also been reported to be expressed in non-pigmented cells, such as osteoclasts, mast cells, and B ...
Yoon Kyung Jeon +8 more
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Microphthalmia-associated transcription factor suppresses invasion by reducing intracellular GTP pools. [PDF]
Oncogene, 2017 Melanoma progression is associated with increased invasion and, often, decreased levels of microphthalmia-associated transcription factor (MITF). Accordingly, downregulation of MITF induces invasion in melanoma cells; however, little is known about the underlying mechanisms. Here, we report for the first time that depletion of MITF results in elevation
Bianchi-Smiraglia A +17 more
europepmc +4 more sources
Microphthalmia in Texel sheep is associated with a missense mutation in the paired-like homeodomain 3 (PITX3) gene. [PDF]
PLoS ONE, 2010 Microphthalmia in sheep is an autosomal recessive inherited congenital anomaly found within the Texel breed. It is characterized by extremely small or absent eyes and affected lambs are absolutely blind. For the first time, we use a genome-wide ovine SNP
Doreen Becker +7 more
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The Microphthalmia-Associated Transcription Factor (MITF) and Its Role in the Structure and Function of the Eye. [PDF]
Genes (Basel)Background/Objectives: The microphthalmia-associated transcription factor (Mitf) has been found to play an important role in eye development, structure, and function. The Mitf gene is responsible for controlling cellular processes in a range of cell types, contributing to multiple eye development processes.
García-Llorca A, Eysteinsson T.
europepmc +3 more sources
Microphthalmia-associated transcription factor up-regulates acetylcholinesterase expression during melanogenesis of murine melanoma cells. [PDF]
J Biol Chem, 2018 Acetylcholinesterase(AChE) hydrolyzes the neurotransmitter acetylcholine in neurons. However,AChEhas been proposed to also have nonneuronal functions in different cell types.
Wu Q +9 more
europepmc +2 more sources
Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) Expression. [PDF]
Int J Mol Sci, 2017 N-acetyltransferase 10 (NAT10) has been considered a target for the treatment of human diseases such as cancer and laminopathies; however, its functional role in the biology of melanocytes is questionable.
Oh TI, Lee YM, Lim BO, Lim JH.
europepmc +2 more sources
microRNA-155, induced by interleukin-1ß, represses the expression of microphthalmia-associated transcription factor (MITF-M) in melanoma cells. [PDF]
PLoS ONE, 2015 Loss of expression of surface antigens represents a significant problem for cancer immunotherapy. Microphthalmia-associated transcription factor (MITF-M) regulates melanocyte fate by driving expression of many differentiation genes, whose protein ...
Nathalie Arts +6 more
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Regulatory and Functional Connection of Microphthalmia-Associated Transcription Factor and Anti-Metastatic Pigment Epithelium Derived Factor in Melanoma [PDF]
Neoplasia: An International Journal for Oncology Research, 2014 Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor superfamily, has potent anti-metastatic effects in cutaneous melanoma through its direct actions on endothelial and melanoma cells.
Asunción Fernández-Barral +17 more
doaj +2 more sources
Microphthalmia-associated transcription factor (MITF) – from Waardenburg syndrome genetics to melanoma therapy [PDF]
Acta Medica Academica, 2010 Microphthalmia-associated transcription factor (MITF) was first discovered as protein coded by gene whose mutations are associated with Waardenburg syndrome. Later, MITF was shown to be key transcription factor regulating melanogenesis.
Ivan Šamija +2 more
doaj +1 more source