Microphthalmia-associated transcription factor in melanoma development and MAP-kinase pathway targeted therapy. [PDF]
Pigment Cell Melanoma Res, 2015 Malignant melanoma is a neoplasm of melanocytes, and the microphthalmia-associated transcription factor (MITF) is essential for the existence of melanocytes.
Wellbrock C, Arozarena I.
europepmc +2 more sources
The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology [PDF]
Laboratory Investigation, 2017 Certain transcription factors have vital roles in lineage development, including specification of cell types and control of differentiation. Microphthalmia-associated transcription factor (MITF) is a key transcription factor for melanocyte development and differentiation.
Akinori, Kawakami, David E, Fisher
openaire +2 more sources
Transcriptional repression of the microphthalmia gene in melanoma cells correlates with the unresponsiveness of target genes to ectopic microphthalmia-associated transcription factor. [PDF]
, 2001 In the melanocyte, expression of genes required for pigment formation is mediated by the microphthalmia transcription factor, which is also critical for the development and survival of normal melanocytes during embryogenesis.
Novotna, H +5 more
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Aquaculture Reports, 2022 Leopard coral grouper (Plectropomus leopardus) is an indispensable kind of fish in the coral reef ecosystems and marine aquaculture, and the body color of leopard coral grouper is exhibited in black, brown or red.
Hongtao Liu +9 more
doaj +1 more source
Induction of Melanocyte-specific Microphthalmia-associated Transcription Factor by Wnt-3a [PDF]
Journal of Biological Chemistry, 2000 Microphthalmia-associated transcription factor (Mitf) plays a critical role in the development of neural crest-derived melanocytes. Here, we show that exogenously added Wnt-3a protein, an intercellular signaling molecule, up-regulates the expression of endogenous melanocyte-specific Mitf (Mitf-M) mRNA in cultured melanocytes.
K, Takeda +8 more
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, 2021 CAMP response element-binding protein; Melanocyte; Melanogenesis; Microphthalmia-associated transcription factor ...
임경민
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Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene. [PDF]
Molecular and Cellular Biology, 1994 Tyrosinase is a rate-limiting enzyme in melanin biosynthesis and is specifically expressed in differentiated melanocytes. We have identified the enhancer element in the 5'-flanking region of the human tyrosinase gene that is responsible for its pigment cell-specific transcription and have termed it tyrosinase distal element (TDE) (positions -1861 to ...
K, Yasumoto +4 more
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OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs
Nature Communications, 2017 Lineage master regulators induce differentiation and how the melanocyte master regulator Microphthalmia-associated transcription factor (MITF) is regulated is unclear.
Danna Sheinboim +12 more
doaj +1 more source
The retinoblastoma protein modulates Tbx2 functional specificity [PDF]
, 2010 Tbx2 is a member of a large family of transcription factors defined by homology to the T-box DNA-binding domain. Tbx2 plays a key role in embryonic development, and in cancer through its capacity to suppress senescence and promote invasiveness.
Colin R. Goding +14 more
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A medaka model to study the the molecular basis of Microphthalmia with Linear Skin defects (MLS) syndrome [PDF]
, 2010 The Microphthalmia with linear skin defects (MLS) syndrome is an X- linked dominant male-lethal neuro-developmental disorder associated to mutations in the holocytochrome c-type synthetase (HCCS) transcript.
Indrieri, Alessia
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