Results 41 to 50 of about 73,036 (190)

An R2R3 MYB transcription factor associated with regulation of the anthocyanin biosynthetic pathway in Rosaceae [PDF]

, 2010
Background The control of plant anthocyanin accumulation is via transcriptional regulation of the genes encoding the biosynthetic enzymes. A key activator appears to be an R2R3 MYB transcription factor.
Wang, Kui-Lin, Kortstee, A.J., Tony K McGhie, McGhie Tony K, Hellens, R.P., Espley Richard V, Hellens Roger P, Grafton, Karryn, Espley, Richard V., Karryn Grafton, Karunairetnam, Sakuntala, Andrew C Allan, Kortstee, Anne, Roger P Hellens, Allan, A.C., Allan, Andrew C., McGhie, T.K., Richard V Espley, Kortstee Anne, Allan Andrew C, Espley, R.V., Sakuntala Karunairetnam, Karunairetnam Sakuntala, Grafton Karryn, McGhie, Tony K., Lin-Wang Kui, Bolitho, Karen, Karen Bolitho, Anne Kortstee, Bolitho Karen, Hellens, Roger P., Lin-Wang, Kui, Kui Lin-Wang   +32 more
core   +1 more source

Endolysosomal Cation Channels and MITF in Melanocytes and Melanoma

Biomolecules, 2021
Microphthalmia-associated transcription factor (MITF) is the principal transcription factor regulating pivotal processes in melanoma cell development, growth, survival, proliferation, differentiation and invasion. In recent years, convincing evidence has
Carla Abrahamian, Christian Grimm
doaj   +1 more source

Induction of Melanocyte-specific Microphthalmia-associated Transcription Factor by Wnt-3a [PDF]

Journal of Biological Chemistry, 2000
Microphthalmia-associated transcription factor (Mitf) plays a critical role in the development of neural crest-derived melanocytes. Here, we show that exogenously added Wnt-3a protein, an intercellular signaling molecule, up-regulates the expression of endogenous melanocyte-specific Mitf (Mitf-M) mRNA in cultured melanocytes.
K, Takeda, K, Yasumoto, R, Takada, S, Takada, K, Watanabe, T, Udono, H, Saito, K, Takahashi, S, Shibahara   +8 more
openaire   +2 more sources

Transcriptional repression of the microphthalmia gene in melanoma cells correlates with the unresponsiveness of target genes to ectopic microphthalmia-associated transcription factor. [PDF]

, 2001
In the melanocyte, expression of genes required for pigment formation is mediated by the microphthalmia transcription factor, which is also critical for the development and survival of normal melanocytes during embryogenesis.
Novotna, H, Novotna, H., Ghanem, Ghanem Elias, Ghanem, G., Vachtenheim, J, Vachtenheim, J.   +5 more
core   +1 more source

Renal cell carcinoma associated with Xp11.2 translocation/transcription factor E3 gene fusion: an adult case report and literature review

Journal of International Medical Research, 2020
Renal cell carcinoma (RCC) associated with Xp11.2 translocation/transcription factor E3 ( TFE3 ) gene fusion is a rare and independent subtype of RCC included in the classification of MiT (microphthalmia-associated transcriptional factor) family ...
Yuxiong Wang, Yuantao Wang, Mingliang Feng, Xin Lian, Yongsheng Lei, Honglan Zhou   +5 more
doaj   +1 more source

Analysis of the differentially expressed genes and characterization of PIMITF genes of the leopard coral grouper (Plectropomus leopardus)

Aquaculture Reports, 2022
Leopard coral grouper (Plectropomus leopardus) is an indispensable kind of fish in the coral reef ecosystems and marine aquaculture, and the body color of leopard coral grouper is exhibited in black, brown or red.
Hongtao Liu, Chen Dai, Xiaoxin li, Dapeng Luo, He Chen, Jing Cui, Guisen Chen, Qingming Liu, Zhigang Tu, Yun Sun   +9 more
doaj   +1 more source

Microphthalmia-associated transcription factor as a regulator for melanocyte-specific transcription of the human tyrosinase gene. [PDF]

Molecular and Cellular Biology, 1994
Tyrosinase is a rate-limiting enzyme in melanin biosynthesis and is specifically expressed in differentiated melanocytes. We have identified the enhancer element in the 5'-flanking region of the human tyrosinase gene that is responsible for its pigment cell-specific transcription and have termed it tyrosinase distal element (TDE) (positions -1861 to ...
K, Yasumoto, K, Yokoyama, K, Shibata, Y, Tomita, S, Shibahara   +4 more
openaire   +2 more sources

Aberrant miR-182 expression promotes melanoma metastasis by repressing FOXO3 and microphthalmia-associated transcription factor [PDF]

, 2013
The highly aggressive character of melanoma makes it an excellent model for probing the mechanisms underlying metastasis, which remains one of the most difficult challenges in treating cancer.
Segura, Miguel F., Álvarez-Díaz, S., Hernando, Eva   +2 more
core   +1 more source

The retinoblastoma protein modulates Tbx2 functional specificity [PDF]

, 2010
Tbx2 is a member of a large family of transcription factors defined by homology to the T-box DNA-binding domain. Tbx2 plays a key role in embryonic development, and in cancer through its capacity to suppress senescence and promote invasiveness.
Colin R. Goding, Goding, CR, Heather M. Shaw, Sascha Ott, Keith W. Vance, Vance, KW, Shaw, HM, Mercedes Rodriguez, Ott, S, Rodriguez, Mercedes, Goding, Colin R., Ott, Sascha, Shaw, Heather M., Rodriguez, M, Vance, Keith W.   +14 more
core   +1 more source

OCT4 impedes cell fate redirection by the melanocyte lineage master regulator MITF in mouse ESCs

Nature Communications, 2017
Lineage master regulators induce differentiation and how the melanocyte master regulator Microphthalmia-associated transcription factor (MITF) is regulated is unclear.
Danna Sheinboim, Itay Maza, Iris Dror, Shivang Parikh, Vladislav Krupalnik, Rachel E. Bell, Asaf Zviran, Yusuke Suita, Ofir Hakim, Yael Mandel-Gutfreund, Mehdi Khaled, Jacob H. Hanna, Carmit Levy   +12 more
doaj   +1 more source