A novel role for microphthalmia-associated transcription factor-regulated pigment epithelium-derived factor during melanoma progression. [PDF]
Am J Pathol, 2015 Microphthalmia-associated transcription factor (MITF) acts via pigment epithelium-derived factor (PEDF), an antiangiogenic protein, to regulate retinal pigment epithelium migration.
Dadras SS +12 more
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Antimelanogenic effect of ginsenoside Rg3 through extracellular signal-regulated kinase-mediated inhibition of microphthalmia-associated transcription factor [PDF]
Journal of Ginseng Research, 2015 Background: Panax ginseng has been used to prolong longevity and is believed to be useful for improving skin complexion. Ginsenosides are the most active components isolated from ginseng, and ginsenoside Rg3 (G-Rg3) in particular has been demonstrated to
Seung Jae Lee +3 more
doaj +2 more sources
Microphthalmia-Associated Transcription Factor in Senescence and Age-Related Diseases [PDF]
Gerontology, 2021 Although microphthalmia-associated transcription factor (MITF) has been known for decades as a key regulator for melanocytic differentiation, recent studies expanded its other roles in multiple biological processes. Among these newfound roles, the relationship between MITF and aging is attractive; however, the underlying mechanism remains elusive. Here,
Jian, Zhang +4 more
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Antioxidant Graphene Oxide Nanoribbon as a Novel Whitening Agent Inhibits Microphthalmia-Associated Transcription Factor-Related Melanogenesis Mechanism [PDF]
ACS Omega, 2020 Hsin-Yu Chou +6 more
doaj +2 more sources
Cancer Gene Therapy, 2022 Gastrointestinal stromal tumors (GISTs) are the most common neoplasms of mesenchymal origin, and most of them emerge due to the oncogenic activation of KIT or PDGFRA receptors. Despite their relevance in GIST oncogenesis, critical intermediates mediating the KIT/PDGFRA transforming program remain mostly unknown.
Elizabeth Proaño-Pérez +8 more
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A novel adamantyl benzylbenzamide derivative, AP736, suppresses melanogenesis through the inhibition of cAMP-PKA-CREB-activated microphthalmia-associated transcription factor and tyrosinase expression [PDF]
, 2021 CAMP response element-binding protein; Melanocyte; Melanogenesis; Microphthalmia-associated transcription factor ...
임경민
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The three M’s: melanoma, microphthalmia‐associated transcription factor and microRNA [PDF]
Pigment Cell & Melanoma Research, 2011 SummaryStudies examining intratumor heterogeneity have indicated that several cancer types, including melanoma, can display phenotypic plasticity, corresponding to their capacity to undergo transient reversible cellular changes. Conceptual models constructed to explain the process of cancer propagation differ in their treatment of intratumor ...
Rachel E, Bell, Carmit, Levy
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Transcription factor complex formation and chromatin fine structure alterations at the murine c-fms (CSF-1 receptor) locus during maturation of myeloid precursor cells [PDF]
, 2002 Expression of the gene for the macrophage colony stimulating factor receptor (CSF-1R), c-fms, has been viewed as a hallmark of the commitment of multipotent precursor cells to macrophages.
Bonifer, Constanze +29 more
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The master role of microphthalmia-associated transcription factor in melanocyte and melanoma biology [PDF]
Laboratory Investigation, 2017 Certain transcription factors have vital roles in lineage development, including specification of cell types and control of differentiation. Microphthalmia-associated transcription factor (MITF) is a key transcription factor for melanocyte development and differentiation.
Akinori, Kawakami, David E, Fisher
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Microphthalmia-Associated Transcription Factor (MITF): Multiplicity in Structure, Function, and Regulation [PDF]
Journal of Investigative Dermatology Symposium Proceedings, 2001 Microphthalmia-associated transcription factor (MITF) regulates the differentiation and development of melanocytes and retinal pigment epithelium and is also responsible for pigment cell-specific transcription of the melanogenesis enzyme genes. Heterozygous mutations in the MITF gene cause auditory-pigmentary syndromes.
Shibahara, Shigeki +6 more
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