Mutation of microphthalmia-associated transcription factor (mitf) in zebrafish sensitizes for glomerulopathy [PDF]
Biology Open, 2019 Different glomerular diseases that affect podocyte homeostasis can clinically present as nephrotic syndrome with massive proteinuria, hypoalbuminemia, hyperlipidemia and edema.
Janina Müller-Deile +9 more
doaj +7 more sources
The underestimated role of the microphthalmia-associated transcription factor (MiTF) in normal and pathological haematopoiesis [PDF]
Cell & Bioscience, 2021 Haematopoiesis, the process by which a restrained population of stem cells terminally differentiates into specific types of blood cells, depends on the tightly regulated temporospatial activity of several transcription factors (TFs).
Alessia Oppezzo, Filippo Rosselli
doaj +6 more sources
Characterizing the Coding Region Determinant-Binding Protein (CRD-BP)-Microphthalmia-associated Transcription Factor (MITF) mRNA interaction. [PDF]
PLoS ONE, 2017 Coding region determinant-binding protein (CRD-BP) binds to the 3'-UTR of microphthalmia-associated transcription factor (MITF) mRNA to prevent its targeted degradation by miR-340.
Gerrit van Rensburg +2 more
doaj +4 more sources
Microphthalmia-Associated Transcription Factor (MITF) Regulates Immune Cell Migration into Melanoma [PDF]
Translational Oncology, 2019 Microphthalmia-associated transcription factor (MITF) is a key transcription factor in melanoma development and progression. MITF amplification and downregulation have been observed in a significant proportion of melanoma patients and correlate with ...
Gabriela M Wiedemann +10 more
doaj +5 more sources
Microphthalmia-Associated Transcription Factor [PDF]
The American Journal of Pathology, 2015 This Correspondence relates to the article by Dadras et al (A Novel Role for Microphthalmia-Associated Transcription Factor-Regulated Pigment Epithelium-Derived Factor during Melanoma Progression.
Benilde Jiménez Cuenca +2 more
core +6 more sources
MITF (microphthalmia-associated transcription factor) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2013 Review on MITF (microphthalmia-associated transcription factor), with data on DNA, on the protein encoded, and where the gene is implicated.
Riddle, ND, Zhang, P
openaire +4 more sources
Brn-2 Represses Microphthalmia-Associated Transcription Factor Expression and Marks a Distinct Subpopulation of Microphthalmia-Associated Transcription Factor–Negative Melanoma Cells [PDF]
Cancer Research, 2008 Abstract The origin of tumor heterogeneity is poorly understood, yet it represents a major barrier to effective therapy. In melanoma and in melanocyte development, the microphthalmia-associated transcription factor (Mitf) controls survival, differentiation, proliferation, and migration/metastasis.
Goodall, Jane +8 more
openaire +9 more sources
Microphthalmia-associated transcription factor is required for mature myotube formation [PDF]
Biochimica et Biophysica Acta (BBA) - General Subjects, 2012 The roles of microphthalmia-associated transcription factor (Mitf) in the skeletal muscle and during myogenesis are unclear.Expression of Mitf in mouse tissues and during myogenesis was evaluated. Effects of Mitf knockdown on myogenesis and gene expression related to myogenesis were subsequently explored. Furthermore, effects of p21, a cyclin-dependent
Ooishi, Ryo +3 more
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Preclinical study of microphthalmia-associated transcription factor inhibitor ML329 in gastrointestinal stromal tumor growth [PDF]
Molecular Therapy: OncologyGastrointestinal stromal tumors (GISTs) comprise about 80% of mesenchymal neoplasms in the gastrointestinal tract. Although imatinib mesylate is the preferred treatment, the development of drug resistance highlights the need for novel therapeutic ...
Mario Guerrero +7 more
doaj +2 more sources
Negative Regulatory Loop between Microphthalmia-Associated Transcription Factor (MITF) and Notch Signaling. [PDF]
Int J Mol Sci, 2019 Melanoma, a melanocyte-origin neoplasm, is a highly metastatic and treatment-resistance cancer. While it is well established that notch signaling activation promotes melanoma progression, little is known about the reciprocal interactions between Notch ...
Golan T, Levy C.
europepmc +2 more sources