Clinical and Molecular Characterization of Microphthalmia-associated Transcription Factor (MITF)-related Renal Cell Carcinoma. [PDF]
Urology, 2021 Objectives: To characterize the clinical presentation, genomic alterations, pathologic phenotype and clinical management of microphthalmia-associated transcription factor (MITF) familial renal cell carcinoma (RCC), caused by a member of the TFE3, TFEB ...
Lang M +6 more
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microRNA-155, induced by interleukin-1ß, represses the expression of microphthalmia-associated transcription factor (MITF-M) in melanoma cells. [PDF]
PLoS ONE, 2015 Loss of expression of surface antigens represents a significant problem for cancer immunotherapy. Microphthalmia-associated transcription factor (MITF-M) regulates melanocyte fate by driving expression of many differentiation genes, whose protein ...
Nathalie Arts +6 more
doaj +3 more sources
The Microphthalmia-Associated Transcription Factor (MITF) and Its Role in the Structure and Function of the Eye. [PDF]
Genes (Basel)Background/Objectives: The microphthalmia-associated transcription factor (Mitf) has been found to play an important role in eye development, structure, and function.
García-Llorca A, Eysteinsson T.
europepmc +2 more sources
Substance P Administered after Myocardial Infarction Upregulates Microphthalmia-Associated Transcription Factor, GATA4, and the Expansion of c-Kit+ Cells. [PDF]
Stem Cells Int, 2020 Microphthalmia-associated transcription factor (MITF), a basic helix-loop-helix leucine zipper transcription factor, can govern gene expression by binding to E box elements in the promoter region of its target gene. Although high levels of MITF have been
Jeong YM, Cheng XW, Kim W.
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MicroRNA-141-3p and microRNA-200a-3p regulate α-melanocyte stimulating hormone-stimulated melanogenesis by directly targeting microphthalmia-associated transcription factor. [PDF]
Sci Rep, 2020 In recent years, it has been reported that non-coding RNAs, especially microRNAs (miRNAs) and long non-coding RNAs, act as melanogenesis-regulating molecules in melanocytes. We found that the expression levels of miR-141-3p and miR-200a-3p were decreased
Itoh T +3 more
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The microphthalmia-associated transcription factor (Mitf) gene and its role in regulating eye function. [PDF]
Sci Rep, 2019 Mutations in the microphthalmia-associated transcription factor (Mitf) gene can cause retinal pigment epithelium (RPE) and retinal dysfunction and degeneration.
García-Llorca A +4 more
europepmc +2 more sources
Preclinical study of microphthalmia-associated transcription factor inhibitor ML329 in gastrointestinal stromal tumor growth [PDF]
Molecular Therapy: OncologyGastrointestinal stromal tumors (GISTs) comprise about 80% of mesenchymal neoplasms in the gastrointestinal tract. Although imatinib mesylate is the preferred treatment, the development of drug resistance highlights the need for novel therapeutic ...
Mario Guerrero +7 more
doaj +2 more sources
Negative Regulatory Loop between Microphthalmia-Associated Transcription Factor (MITF) and Notch Signaling. [PDF]
Int J Mol Sci, 2019 Melanoma, a melanocyte-origin neoplasm, is a highly metastatic and treatment-resistance cancer. While it is well established that notch signaling activation promotes melanoma progression, little is known about the reciprocal interactions between Notch ...
Golan T, Levy C.
europepmc +2 more sources
Inhibition of NAT10 Suppresses Melanogenesis and Melanoma Growth by Attenuating Microphthalmia-Associated Transcription Factor (MITF) Expression. [PDF]
Int J Mol Sci, 2017 N-acetyltransferase 10 (NAT10) has been considered a target for the treatment of human diseases such as cancer and laminopathies; however, its functional role in the biology of melanocytes is questionable.
Oh TI, Lee YM, Lim BO, Lim JH.
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Microphthalmia-associated transcription factor up-regulates acetylcholinesterase expression during melanogenesis of murine melanoma cells. [PDF]
J Biol Chem, 2018 Acetylcholinesterase (AChE) hydrolyzes the neurotransmitter acetylcholine in neurons. However, AChE has been proposed to also have nonneuronal functions in different cell types.
Wu Q +9 more
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