Results 61 to 70 of about 9,717,047 (191)

Absence of meningeal mast cells in the Mitf mutant mouse

Frontiers in Cellular Neuroscience
Mast cells (MCs) are located in the meninges of the central nervous system (CNS), where they play key roles in the immune response. MC-deficient mice are advantageous in delineating the role of MCs in the immune response in vivo.
Alba Sabaté San José, Alba Sabaté San José, Petur Henry Petersen   +2 more
doaj   +1 more source

Sesamol Inhibited Ultraviolet Radiation-Induced Hyperpigmentation and Damage in C57BL/6 Mouse Skin

Antioxidants, 2019
Melanin is synthesized through a series of oxidative reactions initiated with tyrosine and catalyzed by melanogenesis-related proteins such as tyrosinase, tyrosinase-related protein-1 (TRP-1), dopachrome tautomerase (TRP-2), and microphthalmia-associated
Ya-Jhen You, Po-Yuan Wu, Yi-Jung Liu, Chien-Wei Hou, Chin-Sheng Wu, Kuo-Ching Wen, Chien-Yih Lin, Hsiu-Mei Chiang   +7 more
doaj   +1 more source

Sox11 is required to maintain proper levels of Hedgehog signaling during vertebrate ocular morphogenesis. [PDF]

PLoS Genetics, 2014
Ocular coloboma is a sight-threatening malformation caused by failure of the choroid fissure to close during morphogenesis of the eye, and is frequently associated with additional anomalies, including microphthalmia and cataracts.
Lakshmi Pillai-Kastoori, Wen Wen, Stephen G Wilson, Erin Strachan, Adriana Lo-Castro, Marco Fichera, Sebastiano A Musumeci, Ordan J Lehmann, Ann C Morris   +8 more
doaj   +1 more source

The association between neural crest‐derived glia and melanocyte lineages throughout development and disease

Developmental Dynamics, EarlyView.
Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

MITF and PAX3 play distinct roles in melanoma cell migration; outline of a genetic switch theory involving MITF and PAX3 in proliferative and invasive phenotypes of melanoma

Frontiers in Oncology, 2013
Melanoma is a very aggressive neoplasm with a propensity to undergo progression and invasion early in its evolution. The molecular pathways underpinning invasion in melanoma are now just beginning to be elucidated, but a clear understanding of the ...
Michael R Eccles, Shujie eHe, Antonio eAhn, Lynn eSlobbe, Aaron R Jeffs, Han-Seung eYoon, Bruce C Baguley   +6 more
doaj   +1 more source

MIT/TFE family transcription factors, Mitf and Tfec, redundantly promote pigment cell differentiation and retinal epithelium pigmentation in teleosts

Developmental Dynamics, EarlyView.
Abstract Background Transcription factors of the MIT/TFE family—mitfa, mitfb, and tfec—play essential roles in specifying pigment cells derived from neural crest cells in vertebrates. In teleosts, which possess multiple pigment cell types, these factors exhibit partially redundant but largely distinct functions across different pigment lineages.
James Lister, Keisuke Sugiwaka, Tetsuaki Kimura, Rieko Tanaka, Makoto Goda, Hikaru Kobayashi, Chikako Inoue, Kawilarang W. A. Masengi, Kazunori Yamahira, Kiyoshi Naruse, Satoshi Ansai, Robert N. Kelsh, Masahiko Hibi, Hisashi Hashimoto   +13 more
wiley   +1 more source

Immunohistochemical evaluation of microphthalmia-associated transcription factor expression in giant cell lesions [PDF]

Modern Pathology, 2004
Microphthalmia-associated transcription factor (Mitf), a member of the helix-loop-helix transcription factor subfamily, normally expressed in mononuclear and multinucleated osteoclasts, is involved in the terminal differentiation of osteoclasts.
Raja R, Seethala, John R, Goldblum, David G, Hicks, Micheal, Lehman, Jasvir S, Khurana, Terry L, Pasha, Paul J, Zhang   +6 more
openaire   +2 more sources

Comparison amount of microphthalmia-associated transcription factor in vitiligo before and after narrowband-ultraviolet B therapy

Dermatology Reports, 2019
Vitiligo is the most commonly seen depigmentation disease with clinical manifestations of milk colored white macules, complex pathogenesis that is not well understood so that evolution of the disease is unpredictable and therapeutic outcomes are often ...
M. Yulianto Listiawan, Linda Astari, Putri Hendria Wardhani   +2 more
doaj   +1 more source

6p21 translocation renal cell carcinoma: A case report

Urology Case Reports, 2021
6p21 translocation renal cell carcinoma (RCC) was newly classified in the WHO 2016 classification as a subtype of microphthalmia-associated transcription factor (MIT) family translocation RCC.A 42-year-old man was referred to our hospital with an ...
Yuho Sano, Ryuta Tanimoto, Katsumi Sasaki, Satoko Nakamura, Koichi Mizobuchi, Naoto Kuroda   +5 more
doaj   +1 more source