Results 71 to 80 of about 73,036 (190)

Microphthalmia‐associated transcription factor is expressed in projection neurons of the mouse olfactory bulb [PDF]

Genes to Cells, 2015
Microphthalmia‐associated transcription factor (Mitf) is a key regulator for differentiation of the neural crest‐derived melanocytes. Mitf consists of multiple isoforms, including melanocyte‐specific Mitf‐M and widely expressed Mitf‐A and Mitf‐H. Mitf mRNAs are also expressed in the brain, although the identity of Mitf‐expressing cells remains unknown.
Koji, Ohba, Kazuhisa, Takeda, Hiroaki, Yamamoto, Shigeki, Shibahara   +3 more
openaire   +2 more sources

Turnover and function of DNA methylation at transcription factor binding sites [PDF]

, 2014
Cell type identity is largely determined by regulatory networks consistent of various transcription factors. Transcription factor activity requires interaction with DNA and thus critically depends on the accessibility of binding motifs.
Feldmann, Angelika
core   +1 more source

Comparison amount of microphthalmia-associated transcription factor in vitiligo before and after narrowband-ultraviolet B therapy

Dermatology Reports, 2019
Vitiligo is the most commonly seen depigmentation disease with clinical manifestations of milk colored white macules, complex pathogenesis that is not well understood so that evolution of the disease is unpredictable and therapeutic outcomes are often ...
M. Yulianto Listiawan, Linda Astari, Putri Hendria Wardhani   +2 more
doaj   +1 more source

The role of Rho GTPases in facial morphogenesis

Developmental Dynamics, EarlyView.
The role of small GTPases, RHOA, RAC1, and CDC42 and pathway mediators is reviewed in the context of embryonic facial development. Lip fusion requires cytoskeletal remodeling during morphogenesis of the facial processes and during lip fusion. Fnm, frontonasal mass; lnp, lateral nasal process; mnp, medial nasal process; mxp, maxillary process; np, nasal
Isra Ibrahim, Joy M. Richman
wiley   +1 more source

A medaka model to study the the molecular basis of Microphthalmia with Linear Skin defects (MLS) syndrome [PDF]

, 2010
The Microphthalmia with linear skin defects (MLS) syndrome is an X- linked dominant male-lethal neuro-developmental disorder associated to mutations in the holocytochrome c-type synthetase (HCCS) transcript.
Indrieri, Alessia
core  

A Role of Myocardin Related Transcription Factor-A (MRTF-A) in Scleroderma Related Fibrosis. [PDF]

, 2015
In scleroderma (systemic sclerosis, SSc), persistent activation of myofibroblast leads to severe skin and organ fibrosis resistant to therapy. Increased mechanical stiffness in the involved fibrotic tissues is a hallmark clinical feature and a cause of ...
Ayuko Takahashi (789901), Barbara D. Smith (2212672), Takahashi, A, Christopher Denton, Layne, MD, Bahja Ahmed-Abdi, Ayuko Takahashi, Suki, B, Nikitorowicz-Buniak, J, Bela Suki (2212681), Bahja Ahmed-Abdi (2212675), Matthew D. Layne (364786), Markella Ponticos, Ahmed-Abdi, B, Robert Lafyatis, Markella Ponticos (2212669), Xu Shiwen (2212678), Stratton, R, Bela Suki, Barbara D Smith, Richard Stratton (776213), Joanna Nikitorowicz-Buniak (776212), Smith, BD, Christopher Denton (276245), Xu Shiwen, Lafyatis, R, David Abraham (36404), Shiwen, X, David Abraham, Abraham, D, Matthew D Layne, Ponticos, M, Denton, C, Joanna Nikitorowicz-Buniak, Robert Lafyatis (38139), Richard Stratton   +35 more
core   +1 more source

Synthesis and Melanogenesis Effect of 7,8-Dimethoxy-4-Methylcoumarin via MAPK Signaling-Mediated Microphthalmia-Associated Transcription Factor Upregulation

Natural Product Communications, 2022
Tyrosinase ultimately controls the melanogenesis rate of the skin, and tanning and haircare products generally induce the activation of tyrosinase. Moreover, various enzymes, including tyrosinase, tyrosinase-related protein 1 (TRP1), and tyrosinase ...
Min-Sung Kang, Sung-Chan Jang, Taejin Park, Min-Seon Kim, Jin-Soo Park, Won-Jae Chi, Seung-Young Kim   +6 more
doaj   +1 more source

MicroRNA-137 Targets Microphthalmia-Associated Transcription Factor in Melanoma Cell Lines [PDF]

Cancer Research, 2008
Abstract Micropthalmia-associated transcription factor (MITF) is the master regulator of melanocyte development, survival, and function. Frequent alteration in the expression of MITF is detected in melanoma, but the mechanism(s) underlying the alteration in expression have not been completely determined.
Lynne T, Bemis, Robert, Chen, Carol M, Amato, Elizabeth H, Classen, Steven E, Robinson, David G, Coffey, Paul F, Erickson, Yiqun G, Shellman, William A, Robinson   +8 more
openaire   +2 more sources

MAPK Inhibitor‐Tolerant Persister Cells in Melanoma: Mechanisms and Therapeutic Vulnerabilities

Cancer Science, EarlyView.
Melanoma response to MAPK inhibition progresses from drug‐sensitive cells to drug‐tolerant persister states, which enable survival through adaptive signaling, metabolic rewiring, and phenotypic plasticity. These persister cells serve as an intermediate reservoir from which resistant tumors ultimately emerge. ABSTRACT Though major advancements have been
Bhoomi Shah, Mackenzie M. Mayhew, Jacob Sellers, Russell G. Witt   +3 more
wiley   +1 more source

Establishment of an iPSC line (CSUXHi003-A) from a patient with Waardenburg syndrome type Ⅱ caused by a MITF mutation

Stem Cell Research, 2021
Waardenburg syndrome (WS) is a genetic disorder characterized by sensorineural deafness. It has a variable presentation of pigmentation defects. Here, we generated an induced pluripotent stem cell (iPSC) line using episomal plasmid vectors from the ...
Jie Wen, Jian Song, Chufeng He, Jie Ling, Yalan Liu, Hongsheng Chen, Wei Gong, Lingyun Mei, Yong Feng   +8 more
doaj   +1 more source