Results 51 to 60 of about 21,203 (224)
Advanced Science, EarlyView.By integrating 516 whole‐genome resequencing datasets and 236 transcriptomes of allotetraploid common carp, this study establishes the first population‐scale atlas of transposable element (TE) variation in teleost species. TE bursts, relaxed purifying selection, and lineage‐specific loss of ancient insertions shape genome evolution and phenotypic ...
Shuimu Hu +11 more
wiley +1 more source
MITF in melanoma progression, pathology and survival in vivo [PDF]
, 2014 MITF is the master melanocyte transcription factor and has a complex role in melanoma. Both gain- and loss-of function mutations in MITF have been identified in melanoma, although its’ role in melanoma development and the effects of targeting MITF are
Capper, Amy
core
Models of Mitf regulation in RPCs during normal retinal development.
, 2012 (A) In response to RPC program activators, Vsx2 expression is initiated and newly produced protein interacts with preexisting MITF protein, preventing access to targets required for the pigmentation program.
Changjiang Zou (134778) +1 more
core +1 more source
TFAP2 paralogs facilitate chromatin access by MITF.
, 2022 (A) Density heatmaps of anti-MITF CUT&RUN-seq in WT and TFAP2-KO SK-MEL-28 cells, and anti-TFAP2 CUT&RUN-seq in WT and MITF-KO SK-MEL-28 cells at TFAP2-dependent MITF peaks (first cluster), mutually dependent peaks (second cluster) and TFAP2-inhibited ...
Hannah E. Seberg (3804376) +8 more
core +1 more source
Loss of CITED1, an MITF regulator, drives a phenotype switch in vitro and can predict clinical outcome in primary melanoma tumours [PDF]
PeerJ, 2015 CITED1 is a non-DNA binding transcriptional co-regulator whose expression can distinguish the ‘proliferative’ from ‘invasive’ signature in the phenotype-switching model of melanoma. We have found that, in addition to other ‘proliferative’ signature genes,
Jillian Howlin +8 more
doaj +2 more sources
Advanced Science, EarlyView.High‐density type I collagen promotes glutamine (Gln) accumulation–related ferroptosis of TNBC cells via the spermidine/spermine N1‐acetyltransferase 1 (SAT1)‐ argininosuccinate synthase (ASS1) signaling pathway, thus depriving immune cells of Gln supply and inducing IFN‐γ+ CD8+ T cell exhaustion in the TME.
Jinyan Wang +11 more
wiley +1 more source
Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges
BMEMat, EarlyView.This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma +8 more
wiley +1 more source
Regulation of MITF stability by the USP13 deubiquitinase [PDF]
Nature Communications, 2011 The microphthalmia-associated transcription factor (MITF) is essential for melanocyte development. Mutation-induced MAPK pathway activation is common in melanoma and induces MITF phosphorylation, ubiquitination, and proteolysis. Little is known about the enzymes involved in MITF ubiquitination/deubiquitination.
Xiansi, Zhao +4 more
openaire +2 more sources
Food Science and Human Wellness, 2023 Glabridin is the main ingredient of hydrophobic fraction in licorice extract and has been shown to have anti-melanogenesis activity in skins. However, the underlying mechanism(s) remain not completely understood. The aim of this study is thus to elucidate the possible mechanisms related to the melanogenesis suppression by glabridin in cultured B16 ...
Chunxing Pan +11 more
openaire +2 more sources
Scientific Reports, 2022 It is critical to understand the molecular mechanisms governing the regulation of MITF, a lineage specific transcription factor in melanocytes and an oncogene in melanoma. We identified PPP6C, a serine/threonine phosphatase, as a key regulator of MITF in
Carolyn R. Maskin +2 more
doaj +1 more source