Results 71 to 80 of about 21,203 (224)

Mitf over-expression leads to microphthalmia and coloboma in Mitf-cre mice

Experimental Eye Research
ABSTRACT The Microphthalmia associated transcription factor (Mitf) is a critical regulator of the melanocyte lineage and also plays an important role in eye development. Mitf activity in different cell types is controlled in part by ten alternative promoters and their resulting isoforms.
Anne Nathalie Longakit, Hannah Bourget, Catherine D. Van Raamsdonk   +2 more
openaire   +2 more sources

Mitf, with Yki and STRIPAK-PP2A, is a key determinant of form and fate in the progenitor epithelium of the Drosophila eye.

European Journal of Cell Biology
The Microphthalmia-associated Transcription Factor (MITF) governs numerous cellular and developmental processes. In mice, it promotes specification and differentiation of the retinal pigmented epithelium (RPE), and in humans, some mutations in MITF ...
Tianyi Zhang, Qingxiang Zhou, Nisveta Jusić, Wenwen Lu, Francesca Pignoni, Scott J. Neal   +5 more
doaj   +1 more source

Cellular diversity of the developing chick trigeminal ganglion at single‐cell resolution

Developmental Dynamics, EarlyView.
Abstract Background The trigeminal ganglion (TG) integrates sensory input from the face and jaw and is derived from two embryonic cell populations: neural crest and cranial placode. These populations interact during TG development to coordinate specification, differentiation, and organization, but the molecular characteristics of the heterogeneous cell
Arvind Arul Nambi Rajan, Erica J. Hutchins   +1 more
wiley   +1 more source

Ruta graveolens L. in Evidence‐Based Phytotherapy: Pharmacological Activities, Bioactive Compounds and Safety

Phytotherapy Research, EarlyView.
Graphical representation of ethnomedical uses, major bioactive compounds, pharmacological potential and toxicological risks of Ruta graveolens L. ABSTRACT Ruta graveolens L. is widely used in traditional European, Asian, African, and South American medicine for digestive, nervous, cardiovascular, respiratory, and reproductive disorders.
Tetiana Serhiienko, Victoriya Georgiyants, Liudas Ivanauskas, Olha Mykhailenko   +3 more
wiley   +1 more source

Mitf mediates the effect of Sox10 on cell migration.

, 2012
(A) Quantitative real time RTPCR assays were carried out using B16F10 cells transfected with the mutant or wild type Sox10 siRNAs. Mitf expression level was determined to confirm the microarray data.
Jung-Hyun Lee (181962), Chang-Yeol Yeo (181967), Jaesang Kim (181982), Hyun Jung Min (181957), Eok-Soo Oh (181975), Dong Min Kang (181970), Ikjoo Seong (181949), Eun Sook Hwang (181978)   +7 more
core   +1 more source

Microphthalmia-associated transcription factor (MITF) – from Waardenburg syndrome genetics to melanoma therapy

Acta Medica Academica, 2010
Microphthalmia-associated transcription factor (MITF) was first discovered as protein coded by gene whose mutations are associated with Waardenburg syndrome. Later, MITF was shown to be key transcription factor regulating melanogenesis.
Ivan Šamija, Josip Lukač, Zvonko Kusić   +2 more
doaj  

Herbal Therapeutics in Osteoporosis: Mechanisms, Evidence, and Translational Potential

Phytotherapy Research, EarlyView.
Schematic overview of bone remodeling dysregulation in osteoporosis and the multi‐target protective role of herbal therapeutics. ABSTRACT Osteoporosis is a chronic bone disease marked by reduced density and increased fracture risk. Current treatments face limitations in safety, efficacy, and long‐term adherence, prompting interest in alternative ...
Elnaz Vafadar Moradi, Sina Vossoughinia, Zahra Yazdanpanah, Hossein Sobhani, Jalileh Jalali, Mahboobeh Ghasemzadeh Rahbardar   +5 more
wiley   +1 more source

MITF activity is regulated by a direct interaction with RAF proteins in melanoma cells

Communications Biology, 2022
The MITF transcription factor directly binds to the kinase domain of RAF kinases, including ARAF, BRAF and CRAF in melanoma cells. RAF/MITF complex promotes cytoplasmic accumulation of MITF and thus negatively regulates its transcriptional activity.
Charlène Estrada, Liliana Mirabal-Ortega, Laurence Méry, Florent Dingli, Laetitia Besse, Cedric Messaoudi, Damarys Loew, Celio Pouponnot, Corine Bertolotto, Alain Eychène, Sabine Druillennec   +10 more
doaj   +1 more source

Mapping the Tissue Architecture and Endothelial‐PEC Network in HAML Using Single‐Cell and Spatial Transcriptomics

Cancer Science, EarlyView.
Spatial multi‐omics mapping of hepatic angiomyolipoma reveals that PEComas tightly co‐localize with endothelial cells, which drive autophagic flux in adjacent tumor cells via a paracrine PDGFD–PDGFRB–Ras axis, establishing a compensatory survival network that operates in parallel to canonical TSC–mTOR defects.
Xinyang Liu, Yang Guo, Xuehong Tie, Yu Liu, Fuyu Li, Jingkai Liu, Xiaohang Sun, Jiajun Zhao, Feng Geng, Yingjian Liang   +9 more
wiley   +1 more source

A Conditional Zebrafish MITF Mutation Reveals MITF Levels Are Critical for Melanoma Promotion vs. Regression In Vivo [PDF]

, 2014
The microphthalmia-associated transcription factor (MITF) is the "master melanocyte transcription factor" with a complex role in melanoma. MITF protein levels vary between and within clinical specimens, and amplifications and gain- and loss-of-function ...
Jackson, Ian J., Zeng, Zhiqiang, Zhiqiang Zeng, Marie E. Mathers, Richardson, Jennifer, Mathers, Marie E., James A. Lister, Capper, Amy, Patton, E Elizabeth; id_orcid, E. Elizabeth Patton, Ian J. Jackson, Lister, James A., Paranthaman, Karthika, Karthika Paranthaman, Jennifer Richardson   +14 more
core   +1 more source