Results 71 to 80 of about 16,371 (189)
MITF expression in acral melanoma tissues and its association with clinical, pathological characteristics and prognosis [PDF]
Zhongguo aizheng zazhiBackground and purpose: The microphthalmia-associated transcription factor (MITF) plays a complex role in melanoma pathogenesis and progression. It is known to regulate multiple processes both in melanocytes and melanoma cells.
Tong WANG +9 more
doaj +2 more sources
Neoplasia: An International Journal for Oncology Research, 2014 Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor superfamily, has potent anti-metastatic effects in cutaneous melanoma through its direct actions on endothelial and melanoma cells.
Asunción Fernández-Barral +17 more
doaj +1 more source
Pediatric Blood &Cancer, Volume 73, Issue 7, July 2026.ABSTRACT Objective To evaluate the diagnostic yield and utility of universal paired tumor–normal multigene panel sequencing in newly diagnosed pediatric solid and central nervous system (CNS) tumor patients and to compare the detection of germline pathogenic/likely pathogenic variants (PV/LPVs) against established clinical referral criteria for cancer ...
Natalie Waligorski +9 more
wiley +1 more source
Scientific ReportsMicrophthalmia-associated transcription factor (MITF) is a master regulator of melanocyte function, development and plays a significant role in melanoma pathogenesis.
Elisabeth Roider +24 more
doaj +1 more source
Food Science &Nutrition, Volume 14, Issue 7, July 2026.This work systematically explored the anti‐chronic gastritis mechanism of the FAI‐BCT herb pair. UPLC‐Q‐TOF‐MS/MS was applied to identify absorbed prototypes and metabolites of FAI‐BCT in rat plasma. Combining database mining, network pharmacology, molecular docking, and molecular dynamics simulation, we screened the key bioactive components and core ...
Yinghua Ma +4 more
wiley +1 more source
Melanogenesis and MITF expression in primary melanomas: an immunohistochemical study
Surgical and Experimental PathologyBackground The Microphthalmia-associated transcription factor - MITF is a key regulator of melanogenesis, controlling melanin production and pigment phenotype in melanocytes. It also influences cell differentiation, proliferation, and survival.
Karina Munhoz de Paula Alves Coelho +5 more
doaj +1 more source
IJU Case Reports, Volume 9, Issue 4, July 2026.ABSTRACT Introduction Epithelioid angiomyolipoma is a rare perivascular epithelioid cell tumor subtype with malignant potential. Its morphology mimics renal cell carcinoma, posing diagnostic challenges. Half of these cases harbor TSC1/TSC2 alterations, and a small subset features TFE3 rearrangements, mutually exclusive of TSC mutations.
Yuka Kondo +8 more
wiley +1 more source
, 2016 The bHLH-LZ transcription factors MITF and TFEB have been implicated in human disease, with their overexpression increasing the risk of developing cancer. The manner in which their access to E-box target motifs is controlled is an important consideration, as it is via binding to these motifs that bHLH-LZ factors mediate changes in gene expression.
openaire +1 more source
Cancer Heterogeneity and Cancer Cell Plasticity: Molecular Mechanisms and Precision Therapy
MedComm, Volume 7, Issue 7, July 2026.Tumor progression is driven by heterogeneity occurring across multiple biological scales. At the molecular level, tumor cells exhibit alterations across distinct omics layers, including genomic mutations, epigenomic reprogramming, transcriptional changes, and proteomic remodeling, collectively shaping tumor cell phenotypes and functional states.
Hanwen Hu +5 more
wiley +1 more source