Results 71 to 80 of about 16,506 (196)

MITF and TFEB cross-regulation in melanoma cells.

PLoS ONE, 2020
The MITF, TFEB, TFE3 and TFEC (MiT-TFE) proteins belong to the basic helix-loop-helix family of leucine zipper transcription factors. MITF is crucial for melanocyte development and differentiation, and has been termed a lineage-specific oncogene in ...
Josué Ballesteros-Álvarez, Ramile Dilshat, Valerie Fock, Katrín Möller, Ludwig Karl, Lionel Larue, Margrét Helga Ögmundsdóttir, Eiríkur Steingrímsson   +7 more
doaj   +1 more source

MITF protects against oxidative damage-induced retinal degeneration by regulating the NRF2 pathway in the retinal pigment epithelium

Redox Biology, 2020
Oxidative damage is one of the major contributors to retinal degenerative diseases such as age-related macular degeneration (AMD), while RPE mediated antioxidant defense plays an important role in preventing retinopathies.
Shuxian Han, Jianjun Chen, Jiajia Hua, Xiaojuan Hu, Shuhui Jian, Guoxiao Zheng, Jing Wang, Huirong Li, Jinglei Yang, J. Fielding Hejtmancik, Jia Qu, Xiaoyin Ma, Ling Hou   +12 more
doaj   +1 more source

Cutis Tricolor‐Like Pigmentary Mosaicism in Mowat–Wilson Syndrome: Phenotypic Overlap With Ruggieri–Happle Syndrome

Pediatric Dermatology, EarlyView.
ABSTRACT Cutis tricolor (CT) is a rare pigmentary mosaicism characterized by the coexistence of hyperpigmented and hypopigmented areas on a background of normal skin; its syndromic form, Ruggieri–Happle syndrome (RHS), is associated with neurodevelopmental delay, facial dysmorphism, skeletal abnormalities, and other systemic defects.
Didier Bessis, Pierre Meyer, Marjolaine Willems   +2 more
wiley   +1 more source

MITF expression in acral melanoma tissues and its association with clinical, pathological characteristics and prognosis [PDF]

Zhongguo aizheng zazhi
Background and purpose: The microphthalmia-associated transcription factor (MITF) plays a complex role in melanoma pathogenesis and progression. It is known to regulate multiple processes both in melanocytes and melanoma cells.
Tong WANG, Wei SUN, Yu XU, Tu HU, Wanlin LIU, Qiongdan ZHENG, Zijian ZOU, Zirui DONG, Wenjie MA, Yong CHEN   +9 more
doaj   +2 more sources

Melanogenesis and MITF expression in primary melanomas: an immunohistochemical study

Surgical and Experimental Pathology
Background The Microphthalmia-associated transcription factor - MITF is a key regulator of melanogenesis, controlling melanin production and pigment phenotype in melanocytes. It also influences cell differentiation, proliferation, and survival.
Karina Munhoz de Paula Alves Coelho, Jaqueline Stall, Rodrigo Blasius, Bruna Louise Silva, Hercílio Fronza Junior, Paulo Henrique Condeixa de França   +5 more
doaj   +1 more source

Understanding Exosomes in Hair Regeneration

Periodontology 2000, EarlyView.
Abstract Background Alopecia is a prevalent condition correlated with significant psychosocial challenges, while contemporary treatments exhibit variable efficacy, require extended use, and may cause adverse effects. This review aimed to comprehensively assess exosome‐mediated interventions as a novel cell‐free regenerative approach for hair ...
Paras Ahmad, Catherine Davies, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source

The histone deacetylase inhibitor, suberoylanilide hydroxamic acid, restores blood–brain barrier integrity in a human stem cell‐based model of ischaemic stroke

British Journal of Pharmacology, Volume 183, Issue 19, Page 5791-5812, October 2026.
Ischaemic stroke is characterised by acute cerebrovascular occlusion and blood–brain barrier (BBB) breakdown. Our results indicated that the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA) ameliorated the loss of BBB integrity, changed the morphology of brain endothelial cells, increased the level of basement membrane and ...
Anikó Szecskó, Koppány Párdi, Zuhao Cui, Gergő Porkoláb, Zsófia Hoyk, Csilla Kovács, Janet F. Adegbite, Virág Fodor, Nárcisz M. Cser, László Dér, Krisztina Nagy, Csilla Sajben, Roland Tengölics, Mária A. Deli, Szilvia Veszelka   +14 more
wiley   +1 more source

Regulation of MITF and TFEB

, 2016
The bHLH-LZ transcription factors MITF and TFEB have been implicated in human disease, with their overexpression increasing the risk of developing cancer. The manner in which their access to E-box target motifs is controlled is an important consideration, as it is via binding to these motifs that bHLH-LZ factors mediate changes in gene expression.
openaire   +1 more source

Malignant MITF‐Rearranged PEComa With Novel EEF1A1::MITF Fusion

Genes, Chromosomes and Cancer, Volume 65, Issue 9, September 2026.
ABSTRACT MITF‐rearranged PEComas are rare, and their relationship to MITF‐altered melanocytic tumors remains incompletely characterized. We report a malignant superficial soft tissue neoplasm of the thigh in a 45‐year‐old woman harboring a novel EEF1A1::MITF fusion. The tumor was composed of epithelioid to plump spindle cells arranged in sheets, nests,
Sierra Raney, Arivarasan Karunamurthy, Jonhan Ho, Robert Bubar, Maedeh Mohebnasab, John Skaugen, Mohamed Elmoryah, Benjamin Nacev, Richard McGough, Ivy John   +9 more
wiley   +1 more source