Results 81 to 90 of about 16,371 (189)

Rapid Human Skin Barrier Disruption by Sodium Dodecyl Sulfate and Associated Molecular Mechanisms

Allergy, Volume 81, Issue 7, Page 2478-2489, July 2026.
Short‐term exposure to SDS rapidly disrupts human skin barrier integrity within minutes, as detected by real‐time electrical impedance spectroscopy. SDS‐induced barrier dysfunction is driven by oxidative stress, leading to suppression of immune/barrier mediators and activation of stress, lipid remodeling, and epidermal differentiation pathways ...
Manru Li, Huseyn Babayev, Paolo D'Avino, Can Zeyneloğlu, Ceren Bicer, Duygu Yazici, Yagiz Pat, Per Svedenhag, Nicolas Gaudenzio, Cezmi A. Akdis, Yasutaka Mitamura   +10 more
wiley   +1 more source

Heme Oxygenase‐1 Differentially Controls Pigmentation in Physiological and Pathological Melanogenesis

Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.
HO‐1 acts as a context‐dependent regulator of pigmentation, enhancing tyrosinase activity and melanin accumulation in melanoma cells while having no detectable effect on pigmentation in the non‐malignant melanocyte models tested. ABSTRACT Melanogenesis is a defining feature of melanocyte biology and influences melanoma pathogenesis; however, tumor ...
Agnieszka Seretny, Grażyna Jamróg, Jacek Stępniewski, Maciej Cieśla, Witold Nowak, Rościsław Krutyhołowa, Martin Petrovic, Anna Tejchman‐Skrzyszewska, Milena Mazan, Halina Waś, Wolfgang Weninger, Matthias Farlik, Alicja Józkowicz, Anna Kusienicka   +13 more
wiley   +1 more source

Comparison of Human Melanoma Single Cell Profiles to Evolutionary Medicine Model Xiphophorus Provides Insights in Disease Control

Pigment Cell &Melanoma Research, Volume 39, Issue 4, July 2026.
Single‐nucleus RNA sequencing analysis of Xiphophorus melanoma, an evolutionary medicine model, revealed cellular heterogeneity that closely mirrors that of human melanoma. Immune and tumor cell subtyping identified an immune‐evasive tumor microenvironment. This melanoma cell atlas provides a framework for investigating conserved cellular and molecular
Yuan Lu, Will Boswell, Rachel Carroll, Maggs X, Yanting Xing, Wesley C. Warren, Manfred Schartl   +6 more
wiley   +1 more source

Novel mechanisms of MITF regulation identified in a mouse suppressor screen

EMBO Reports
MITF, a basic Helix-Loop-Helix Zipper (bHLHZip) transcription factor, plays vital roles in melanocyte development and functions as an oncogene. We perform a genetic screen for suppressors of the Mitf-associated pigmentation phenotype in mice and identify
Hong Nhung Vu, Matti Már Valdimarsson, Sara Sigurbjörnsdóttir, Kristín Bergsteinsdóttir, Julien Debbache, Keren Bismuth, Deborah A Swing, Jón H Hallsson, Lionel Larue, Heinz Arnheiter, Neal G Copeland, Nancy A Jenkins, Petur O Heidarsson, Eiríkur Steingrímsson   +13 more
doaj   +1 more source

CITED1 is a novel binding partner of MITF that influences the MITF-directed transcriptional profile in melanoma

, 2017
We previously demonstrated how CITED1 knockdown in melanoma cells had the capacity to perturb expression of a significant number of genes that comprised MITF and several of its known transcriptional targets. This manifest as a switch from a more invasive to a more proliferative gene signature phenotype.
Lettiero, Barbara, Lauss, Martin, Borg, Ake, Gruvberger-Saal, Sofia, Jönsson, Goran B, Howlin, Jillian   +5 more
openaire   +1 more source

MITF regulates autophagy and extracellular vesicle cargo in gastrointestinal stromal tumors

Molecular Biomedicine
The role of Microphthalmia-associated Transcription Factor (MITF) in gastrointestinal stromal tumors (GISTs) remains unclear, although previous studies suggest it contributes to tumor growth regulation.
Elizabeth Proaño-Pérez, Eva Serrano-Candelas, Mario Guerrero, David Gómez-Peregrina, Carlos Llorens, Beatriz Soriano, Ana Gámez-Valero, Marina Herrero-Lorenzo, Eulalia Martí, César Serrano, Margarita Martin   +10 more
doaj   +1 more source

TRIM63 Overexpression in FISH-Negative MiTF Family Altered Renal Cell Carcinoma (MiTF RCC)

Modern Pathology
TFE3 and TFEB break-apart fluorescent in situ hybridization (FISH) assays are the "gold standard" for diagnostic confirmation of microphthalmia-associated transcription factor (MiTF) family-altered renal cell carcinoma (MiTF RCC), which includes TFE3-rearranged RCC and TFEB-altered RCC.
Rahul Mannan, Ying-Bei Chen, Xiaoming Wang, Yuping Zhang, Noshad Hosseini, Ankur R. Sangoi, Andres Acosta, Sean R. Williamson, Somnath Mahapatra, Anya K. Chinnaiyan, Jing Hu, Ulka Vaishampayan, Lina Shao, Bryan L. Betz, Annette S. Kim, Xuhong Cao, Fengyun Su, Rui Wang, Pedram Argani, Noah Brown, Satish K. Tickoo, Arul M. Chinnaiyan, Victor E. Reuter, Saravana M. Dhanasekaran, Rohit Mehra   +24 more
openaire   +2 more sources

Antagonistic roles for MITF and TFE3 in melanoma plasticity

Cell Reports
Summary Melanoma cells have the ability to switch from a melanocytic and proliferative state to a mesenchymal and invasive state and back again. This plasticity drives intra-tumoral heterogeneity, progression, and therapeutic resistance.
Jeremy Chang, Katelyn R. Campbell-Hanson, Marion Vanneste, Nicholas I. Bartschat, Ryan Nagel, Asdis K Arnadottir, Hong Nhung Vu, Collin Montgomery, Julius Yevdash, Jiarui Jiang, Ardith Bhinu, Annika Helverson, Michael D. Henry, Eiríkur Steingrímsson, Ronald J. Weigel, Robert A. Cornell, Colin Kenny   +16 more
openaire   +4 more sources

MITF links maturation and quiescence

The Journal of Cell Biology, 2004
The coordination of cell differentiation with exit from the cell division cycle may help to limit organ size and prevent tumor formation. But the mechanism that links these two processes is unknown for most cell types. On page 35, Loercher et al. show that, in melanocytes, the link is the MITF transcription factor.
openaire   +2 more sources

Effect of MITF-M and MITF-A Overexpression on the Dendrtic Formation in Melanocytes

Korean Journal of Physical Anthropology, 2016
In Sook Jo, Kyung-Cheol Sohn, Chang Deok Kim, Young Ho Lee   +3 more
openaire   +1 more source