Results 81 to 90 of about 21,203 (224)

Meningeal Melanocytes in the Mouse: Distribution and Dependence on Mitf [PDF]

Frontiers in Neuroanatomy, 2015
Melanocytes are pigment producing cells derived from the neural crest. They are primarily found in the skin and hair follicles, but can also be found in other tissues including the eye, ear and heart. Here, we describe the distribution of pigmented cells in C57BL/6J mouse meninges, the membranes that envelope the brain.
Stefan Arni Hafsteinsson Gudjohnsen, Stefan Arni Hafsteinsson Gudjohnsen, Diahann A. M. Atacho, Diahann A. M. Atacho, Franck eGesbert, Graca eRaposo, Ilse eHurbain, Ilse eHurbain, Lionel eLarue, Eirikur eSteingrimsson, Petur Henry Petersen   +10 more
openaire   +3 more sources

Disseminated Xanthogranuloma Harboring a GAB2::BRAF Fusion and MITF Pathogenic Variant Successfully Treated With Cobimetinib: A Rare Case Report

Journal of Cutaneous Pathology, EarlyView.
ABSTRACT Several activating mutations and gene fusions involving the mitogen‐activated protein kinase (MAPK) pathway have appeared in the literature regarding histiocytic neoplasms. We identified a GAB2::BRAF fusion in a cutaneous lesion of a 36‐year‐old male who developed central diabetes insipidus and reddish‐pink grouped papules on the bilateral ...
Pauline C. Xu, Allison M. Cushman‐Vokoun, Christopher R. D’Angelo, Dinesh Pradhan   +3 more
wiley   +1 more source

Cytology‐First Diagnostic Workflow for Melanoma of Unknown Primary With Molecular Profiling

Cytopathology, EarlyView.
Cytology‑first diagnostic workflow for melanoma of unknown primary. Fine‑needle aspiration of an enlarged lymph node enables rapid cytologic evaluation and immunocytochemical confirmation of melanocytic lineage (SOX10). This early cytologic diagnosis facilitates timely surgical excision and comprehensive genomic profiling, supporting integrated ...
Hong Yu, Mokhtar Abdelhammed, Xu Cao, Nisha S. Ramani   +3 more
wiley   +1 more source

Out of the Ordinary, but Not Out of the Question: Atypia in Pancreatic Lesions Is Not Always Carcinoma

Cytopathology, EarlyView.
An incidental pancreatic lesion in a 69‐year‐old woman was sampled by EUS‐guided fine‐needle biopsy. Integrated cytopathological and histopathological evaluation with immunochemical staining supported organ‐preserving surgery. ABSTRACT Pancreatic perivascular epithelioid cell tumours (PEComas) are exceptionally rare mesenchymal neoplasms.
Maja Kebe Radulovic, Branislava Rankovic, Ajda Toni, Margareta Zlajpah, Darko Siuka   +4 more
wiley   +1 more source

Update of the S1‐guideline atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS)

JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.
Summary Atypical fibroxanthoma (AFX) and pleomorphic dermal sarcoma (PDS) are rare cutaneous neoplasms representing histomorphological, genetic as well as epigenetic variants of one disease spectrum. Both tumors manifest as nonspecific, often ulcerated nodules in chronically sun‐damaged skin. AFX is a well‐demarcated, often rapidly growing tumor.
Doris Helbig, Mirjana Ziemer, Diana Crisan, Edgar Dippel, Michael Erdmann, Uwe Hillen, Muemtaz Koeksal, Ulrike Leiter, Thomas Mentzel, Lars Erik Podleska, Jochen Utikal, Dagmar von Bubnoff, Carsten Weishaupt, Selma Ugurel   +13 more
wiley   +1 more source

Role and regulation of MITF in melanocytes and melanoma [PDF]

, 2016
One key to understanding how cells integrate and how they respond to diverse stimuli in order to direct a transcriptional response is knowing how a transcription factor may be directed to an appropriate subset of its target genes.

core   +1 more source

MITF and TFEB cross-regulation in melanoma cells.

PLoS ONE, 2020
The MITF, TFEB, TFE3 and TFEC (MiT-TFE) proteins belong to the basic helix-loop-helix family of leucine zipper transcription factors. MITF is crucial for melanocyte development and differentiation, and has been termed a lineage-specific oncogene in ...
Josué Ballesteros-Álvarez, Ramile Dilshat, Valerie Fock, Katrín Möller, Ludwig Karl, Lionel Larue, Margrét Helga Ögmundsdóttir, Eiríkur Steingrímsson   +7 more
doaj   +1 more source

Novel and emerging cutaneous soft tissue tumours

Histopathology, EarlyView.
This review outlines the defining histopathological, immunophenotypic and molecular features of novel and emerging cutaneous soft tissue tumours, including hybrid superficial ALK‐rearranged myxoid spindle cell neoplasm/epithelioid fibrous histiocytoma, superficial neurocristic tumour, ALK‐rearranged epithelioid vascular neoplasm and MITF pathway ...
Saba Shafi, Josephine K Dermawan
wiley   +1 more source

Generation and analysis of mice lacking the RPE–specific D-isoform of Mitf (Mitf^mi-ΔD/Mitf^mi-ΔD).

, 2012
(A) Top: Schematic diagrams showing a region of the Mitf gene containing exons 1H, 1D, and 1B; Middle: the targeting construct with a novel BamHI restriction site and a floxed Neomycin cassette in place of 5.8 kbp of the D-Mitf promoter/exon 1D region ...
Katharina Clore-Gronenborn (153594), Heinz Arnheiter (153598), Jingxing Ou (153590), James Pickel (153596), Kapil Bharti (153586), Melanie Gasper (153588), Martha Brucato (153592)   +6 more
core   +1 more source

TFAP2 and MITF co-regulate pigmentation and cell differentiation genes in SK-MEL-28 cell lines.

, 2022
(A) Venn diagram representing the overlap of genes apparently directly activated by MITF (i.e., expression lower in MITF-KO than in WT cells, FDR TFAP2-KO than in WT cells, FDR B) Gene ontology (GO) biological process analysis enriched among MITF- and ...
Hannah E. Seberg (3804376), Gregory Bonde (130382), Christopher M. Franke (12557816), Ramile Dilshat (9029712), Eric Van Otterloo (241891), Eiríkur Steingrímsson (245726), Robert A. Cornell (8933123), Colin Kenny (8830949), Annika Helverson (12557813)   +8 more
core   +1 more source