Results 61 to 70 of about 21,203 (224)
BMEMat, EarlyView.Plant‐derived extracellular vesicles offer numerous advantages and are regarded as highly promising candidates in the field of biomedicine. Abstract Extracellular vesicles (EVs) are double‐membrane vesicular structures that can be secreted by nearly all living cells.
Zilin Li +6 more
wiley +1 more source
Diagnostic Cytopathology, EarlyView.ABSTRACT Fine‐needle aspiration cytology specimens are frequently utilized for ancillary studies to identify diagnostic and prognostic information. This case highlights diagnostic pitfalls and challenges in diagnosing NUTM1‐rearranged neoplasia on pancreatic cytology.
Terrance J. Lynn
wiley +1 more source
Developmental Dynamics, EarlyView.Abstract Neural crest cells are a transient cell population that emerges from the dorsal neural tube during neurulation and migrates extensively throughout the embryo. Among their diverse derivatives, glial cells (such as Schwann and satellite ganglionic cells) and melanocytes represent two major lineages. In vitro studies suggested they share a common
Chaya Kalcheim
wiley +1 more source
Interactions between MITF and HDAC7.
, 2015 (A) Schematic of myc-HDAC7 deletion constructs with amino acid numbers and HDAC7 known functional domains indicated. (B) 293T cells were transfected with plasmids encoding FLAG-MITF and the indicated myc-tagged HDAC7 constructs, subjected to FLAG ...
Melissa Stemig (723969) +8 more
core +1 more source
05 | Revisiting cancer risk associated with the MITF p.e318k variant beyond melanoma
Dermatology ReportsBackground: The p.E318K variant of the Melanocyte Inducing Transcription Factor (MITF) has been implicated in genetic predisposition to melanoma as an intermediate penetrance allele.
Italian Melanoma Intergroup
doaj +1 more source
Role of SoxE transcription factors in development and disease
Developmental Dynamics, EarlyView.Abstract Sox8, Sox9, and Sox10 arose by multiple rounds of genome duplications from a single SoxE gene in ancestral vertebrates. In this review, we will briefly discuss the molecular structure and function of SoxE transcription factors and their evolutionary origin. We will then discuss their expression, function, and developmental disorders.
Merin Lawrence, Gerhard Schlosser
wiley +1 more source
MITF induces escape from innate immunity in melanoma
Journal of Experimental & Clinical Cancer Research, 2021 Background The application of immune-based therapies has revolutionized cancer treatment. Yet how the immune system responds to phenotypically heterogeneous populations within tumors is poorly understood.
Luis Sánchez-del-Campo +9 more
doaj +1 more source
Developmental Dynamics, EarlyView.Abstract Background Transcription factors of the MIT/TFE family—mitfa, mitfb, and tfec—play essential roles in specifying pigment cells derived from neural crest cells in vertebrates. In teleosts, which possess multiple pigment cell types, these factors exhibit partially redundant but largely distinct functions across different pigment lineages.
James Lister +13 more
wiley +1 more source
Low MITF/AXL ratio predicts early resistance to multiple targeted drugs in melanoma. [PDF]
, 2014 Increased expression of the Microphthalmia-associated transcription factor (MITF) contributes to melanoma progression and resistance to BRAF pathway inhibition.
Graeber, Thomas G +18 more
core +1 more source