Results 91 to 100 of about 21,203 (224)

MITF Regulated Osteoclast Differentiation And Macrophge Polization In Periodontitis

International Dental Journal
Aim or purpose: To elucidate the role of microphthalmia-associated transcription factor (MITF) in periodontitis and investigate its regulatory mechanisms in M1 macrophage polarization and osteoclast differentiation. Materials and methods: MITF expression
Shengbin Huang
doaj   +1 more source

MITF protects against oxidative damage-induced retinal degeneration by regulating the NRF2 pathway in the retinal pigment epithelium

Redox Biology, 2020
Oxidative damage is one of the major contributors to retinal degenerative diseases such as age-related macular degeneration (AMD), while RPE mediated antioxidant defense plays an important role in preventing retinopathies.
Shuxian Han, Jianjun Chen, Jiajia Hua, Xiaojuan Hu, Shuhui Jian, Guoxiao Zheng, Jing Wang, Huirong Li, Jinglei Yang, J. Fielding Hejtmancik, Jia Qu, Xiaoyin Ma, Ling Hou   +12 more
doaj   +1 more source

Bakuchiol: From structural mimicry to systems‐level skin biology

International Journal of Cosmetic Science, EarlyView.
Convergent outcomes, divergent mechanisms: bakuchiol vs. retinol. Bakuchiol exhibits functional convergence with retinol in improving extracellular matrix integrity, epidermal differentiation and barrier function, while operating through distinct mechanisms.
Ratan K. Chaudhuri
wiley   +1 more source

MITF expression in acral melanoma tissues and its association with clinical, pathological characteristics and prognosis [PDF]

Zhongguo aizheng zazhi
Background and purpose: The microphthalmia-associated transcription factor (MITF) plays a complex role in melanoma pathogenesis and progression. It is known to regulate multiple processes both in melanocytes and melanoma cells.
Tong WANG, Wei SUN, Yu XU, Tu HU, Wanlin LIU, Qiongdan ZHENG, Zijian ZOU, Zirui DONG, Wenjie MA, Yong CHEN   +9 more
doaj   +2 more sources

Disrupting Hedgehog signaling in melanocytes by SUFU knockout leads to ocular melanocytosis and anterior segment malformation

Disease Models & Mechanisms, 2023
Weizhuo Wang, Feiyang Li, Jing Wang, Zuimeng Liu, Meiyu Tian, Zhenhang Wang, Huirong Li, Jia Qu, Yu Chen, Ling Hou   +9 more
doaj   +1 more source

MITF regulates IDH1, NNT, and a transcriptional program protecting melanoma from reactive oxygen species

Scientific Reports
Microphthalmia-associated transcription factor (MITF) is a master regulator of melanocyte function, development and plays a significant role in melanoma pathogenesis.
Elisabeth Roider, Alexandra I. T. Lakatos, Alicia M. McConnell, Poguang Wang, Alina Mueller, Akinori Kawakami, Jennifer Tsoi, Botond L. Szabolcs, Anna A. Ascsillán, Yusuke Suita, Vivien Igras, Jennifer A. Lo, Jennifer J. Hsiao, Rebecca Lapides, Dorottya M. P. Pál, Anna S. Lengyel, Alexander Navarini, Arimichi Okazaki, Othon Iliopoulos, István Németh, Thomas G. Graeber, Leonard Zon, Roger W. Giese, Lajos V. Kemeny, David E. Fisher   +24 more
doaj   +1 more source

Understanding Exosomes in Hair Regeneration

Periodontology 2000, EarlyView.
Abstract Background Alopecia is a prevalent condition correlated with significant psychosocial challenges, while contemporary treatments exhibit variable efficacy, require extended use, and may cause adverse effects. This review aimed to comprehensively assess exosome‐mediated interventions as a novel cell‐free regenerative approach for hair ...
Paras Ahmad, Catherine Davies, Anton Sculean, Richard J. Miron   +3 more
wiley   +1 more source

MITF - A controls branching morphogenesis and nephron endowment. [PDF]

, 2017
Congenital nephron number varies widely in the human population and individuals with low nephron number are at risk of developing hypertension and chronic kidney disease.
Aurélie Phelep, Serge Garbay, Langa-Vives, Francina, Gerard Friedlander, Burtin, Martine, Martine Burtin, Sophie Berissi, Francina Langa-Vives, Pontoglio, Marco, Denise Laouari, Kapil Bharti, Phelep, Aurélie, Fischer, Evelyne, Marco Pontoglio, Blanc, Thomas, Clément Nguyen, Evelyne Fischer, Heinz Arnheiter, Tammaccaro, Salvina, Druilhe, Anne, Thomas Blanc, Florence Vasseur, Anne Druilhe, Garbay, Serge, Salvina Tammaccaro, Nguyen, Clement, Friedlander, Gerard, Berissi, Sophie, Fabiola Terzi, Bharti, Kapil, Terzi, Fabiola, Arnheiter, Heinz, Laouari, Denise, Vasseur, Florence   +33 more
core   +1 more source

Regulatory and Functional Connection of Microphthalmia-Associated Transcription Factor and Anti-Metastatic Pigment Epithelium Derived Factor in Melanoma

Neoplasia: An International Journal for Oncology Research, 2014
Pigment epithelium-derived factor (PEDF), a member of the serine protease inhibitor superfamily, has potent anti-metastatic effects in cutaneous melanoma through its direct actions on endothelial and melanoma cells.
Asunción Fernández-Barral, Jose Luis Orgaz, Pablo Baquero, Zaheer Ali, Alberto Moreno, María Tiana, Valentí Gómez, Erica Riveiro-Falkenbach, Carmen Cañadas, Sandra Zazo, Corine Bertolotto, Irwin Davidson, Jose Luis Rodríguez-Peralto, Ignacio Palmero, Federico Rojo, Lasse Dahl Jensen, Luis del Peso, Benilde Jiménez   +17 more
doaj   +1 more source

Mitophagy in skeletal muscle: Impact of ageing, exercise and disuse

Experimental Physiology, EarlyView.
Abstract Skeletal muscle plays an important role in whole‐body health, quality of life and regulation of metabolism. The maintenance of a healthy mitochondrial pool is imperative for the preservation of skeletal muscle quality and is mediated through mitochondrial quality control consisting of mitochondrial turnover mediated by a balance between ...
Anastasiya Kuznyetsova, David A. Hood
wiley   +1 more source