Results 91 to 100 of about 16,506 (196)

CPTCs Drive Somatic‐Visceral Communication via the Wnt Axis in Somatic Mechanotherapy: A Single‐Cell Deep Learning Study

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
Using an interpretable deep learning framework (CARSS) applied to multi‐tissue single‐cell RNA sequencing, we identify CD34⁺PDGFRα⁺ telocytes (CPTCs) as the primary mechanosensors bridging somatic acupuncture stimulation and visceral repair. Mechanical force at acupoints activates an AP‐1/Hsp70 immediate‐early gene program in fascial CPTCs, triggering ...
Haixiang Huang, Zhenwei Zhang, Bingbing Shen, Jianming Yue, Lu Mei, Xudong Zhu, Yonghong Shi, Qianmei Zhu, Yeping Shi, Yifan Luo, Yitong Xing, Meng Dai, Qiusheng Chen   +12 more
wiley   +1 more source

A MAFG~MITF complex drives melanoma phenotype switching and progression

Nature Communications
Phenotype switching, a key driver of melanoma progression and therapy resistance, is governed by the lineage transcription factor MITF. Here, we identify the small MAF family transcription factor MAFG as a critical regulator of MITF activity and melanoma
Olga Vera, Michael Martinez, Zulaida Soto-Vargas, Kaizhen Wang, Xiaonan Xu, Nicol Mecozzi, Harini Murikipudi, Sara Ruiz-Buceta, Manon Chadourne, Benjamin Posorske, Ariana Angarita, Ilah Bok, Juan D. Ulloa Arrieta, Qian Liu, Yumi Kim, Jane L. Messina, Kenneth Y. Tsai, Michael B. Major, Eric K. Lau, Xiaoqing Yu, Inmaculada Ibanez de Caceres, Florian A. Karreth   +21 more
doaj   +1 more source

TRIM63 Overexpression in FISH-Negative MiTF Family Altered Renal Cell Carcinoma (MiTF RCC)

Modern Pathology
TFE3 and TFEB break-apart fluorescent in situ hybridization (FISH) assays are the "gold standard" for diagnostic confirmation of microphthalmia-associated transcription factor (MiTF) family-altered renal cell carcinoma (MiTF RCC), which includes TFE3-rearranged RCC and TFEB-altered RCC.
Rahul Mannan, Ying-Bei Chen, Xiaoming Wang, Yuping Zhang, Noshad Hosseini, Ankur R. Sangoi, Andres Acosta, Sean R. Williamson, Somnath Mahapatra, Anya K. Chinnaiyan, Jing Hu, Ulka Vaishampayan, Lina Shao, Bryan L. Betz, Annette S. Kim, Xuhong Cao, Fengyun Su, Rui Wang, Pedram Argani, Noah Brown, Satish K. Tickoo, Arul M. Chinnaiyan, Victor E. Reuter, Saravana M. Dhanasekaran, Rohit Mehra   +24 more
openaire   +2 more sources

Antagonistic roles for MITF and TFE3 in melanoma plasticity

Cell Reports
Summary Melanoma cells have the ability to switch from a melanocytic and proliferative state to a mesenchymal and invasive state and back again. This plasticity drives intra-tumoral heterogeneity, progression, and therapeutic resistance.
Jeremy Chang, Katelyn R. Campbell-Hanson, Marion Vanneste, Nicholas I. Bartschat, Ryan Nagel, Asdis K Arnadottir, Hong Nhung Vu, Collin Montgomery, Julius Yevdash, Jiarui Jiang, Ardith Bhinu, Annika Helverson, Michael D. Henry, Eiríkur Steingrímsson, Ronald J. Weigel, Robert A. Cornell, Colin Kenny   +16 more
openaire   +4 more sources

MITF links maturation and quiescence

The Journal of Cell Biology, 2004
The coordination of cell differentiation with exit from the cell division cycle may help to limit organ size and prevent tumor formation. But the mechanism that links these two processes is unknown for most cell types. On page 35, Loercher et al. show that, in melanocytes, the link is the MITF transcription factor.
openaire   +2 more sources

CITED1 is a novel binding partner of MITF that influences the MITF-directed transcriptional profile in melanoma

, 2017
We previously demonstrated how CITED1 knockdown in melanoma cells had the capacity to perturb expression of a significant number of genes that comprised MITF and several of its known transcriptional targets. This manifest as a switch from a more invasive to a more proliferative gene signature phenotype.
Lettiero, Barbara, Lauss, Martin, Borg, Ake, Gruvberger-Saal, Sofia, Jönsson, Goran B, Howlin, Jillian   +5 more
openaire   +1 more source

Effect of MITF-M and MITF-A Overexpression on the Dendrtic Formation in Melanocytes

Korean Journal of Physical Anthropology, 2016
In Sook Jo, Kyung-Cheol Sohn, Chang Deok Kim, Young Ho Lee   +3 more
openaire   +1 more source

MITF Positive [PDF]

, 2020
openaire   +1 more source

MYO5A Gene Is a Target of MITF in Melanocytes [PDF]

Journal of Investigative Dermatology, 2017
Cleidson P, Alves, Satoru, Yokoyama, Lucas, Goedert, Carmen L S, Pontes, Josane F, Sousa, David E, Fisher, Enilza M, Espreafico   +6 more
openaire   +2 more sources

Emerging roles of MITF as a crucial regulator of immunity

Experimental and Molecular Medicine
Microphthalmia-associated transcription factor (MITF), a basic helix-loop-helix leucine zipper transcription factor (bHLH-Zip), has been identified as a melanocyte-specific transcription factor and plays a critical role in melanocyte survival ...
Aram Lee, Jihyun Lim, Jong-Seok Lim
doaj   +1 more source