Results 91 to 100 of about 16,371 (189)

The Many Roles of MITF in Melanoma

Single Cell Biology, 2017
Microphthalmia-associated transcription factor (MITF) plays pivotal role in the maintenance of the melanocyte lineage, differentiation of normal and malignant melanocytes and the survival of melanoma cells. MITF regulates expression of many genes with critical functions in cell differentiation, proliferation, and pro-survival properties. Melanoma
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Emerging roles of MITF as a crucial regulator of immunity

Experimental and Molecular Medicine
Microphthalmia-associated transcription factor (MITF), a basic helix-loop-helix leucine zipper transcription factor (bHLH-Zip), has been identified as a melanocyte-specific transcription factor and plays a critical role in melanocyte survival ...
Aram Lee, Jihyun Lim, Jong-Seok Lim
doaj   +1 more source

MITF Gene [PDF]

, 2020
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MITF Positive [PDF]

, 2020
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Targeting MITF in the tolerance-phase

Oncotarget, 2016
Arozarena, Imanol, Smith, Michael P, Wellbrock, Claudia   +2 more
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Revealing mitf functions and visualizing allografted tumor metastasis in colorless and immunodeficient Xenopus tropicalis

Communications Biology
Transparent immunodeficient animal models not only enhance in vivo imaging investigations of visceral organ development but also facilitate in vivo tracking of transplanted tumor cells.
Rensen Ran, Lanxin Li, Tingting Xu, Jixuan Huang, Huanhuan He, Yonglong Chen   +5 more
doaj   +1 more source

MYO5A Gene Is a Target of MITF in Melanocytes [PDF]

Journal of Investigative Dermatology, 2017
Cleidson P, Alves, Satoru, Yokoyama, Lucas, Goedert, Carmen L S, Pontes, Josane F, Sousa, David E, Fisher, Enilza M, Espreafico   +6 more
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Regulation of MITF and Brn2 in melanoma

, 2014
Melanoma is the most aggressive skin cancer with high recurrence and low survival rate. In addition to genetic mechanisms, resistance also arises from phenotypic heterogeneity in which a proportion of cells, the so-called melanoma stem or initiating cells, survive therapy.
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MITF-Driven melanoma plasticity as a core mechanism of therapy resistance: integrating microenvironmental signaling, mechanotransduction, and metabolic reprogramming. [PDF]

Cell Cycle
Kisielewska M, Suwała S, Drąg-Zalesińska M, Rembiałkowska N.   +3 more
europepmc   +1 more source

Structure-Based Virtual Screening and Mechanistic Characterization of Methotrexate and Selinexor as Potent Anti-Melanogenic Agents via Multi-Pathway Suppression of MITF. [PDF]

Cells
Zhang Z, Li H, Shi Z, Bai X, Yin P, Yang L.   +5 more
europepmc   +1 more source