Results 111 to 120 of about 21,203 (224)

Novel mechanisms of MITF regulation identified in a mouse suppressor screen

EMBO Reports
MITF, a basic Helix-Loop-Helix Zipper (bHLHZip) transcription factor, plays vital roles in melanocyte development and functions as an oncogene. We perform a genetic screen for suppressors of the Mitf-associated pigmentation phenotype in mice and identify
Hong Nhung Vu, Matti Már Valdimarsson, Sara Sigurbjörnsdóttir, Kristín Bergsteinsdóttir, Julien Debbache, Keren Bismuth, Deborah A Swing, Jón H Hallsson, Lionel Larue, Heinz Arnheiter, Neal G Copeland, Nancy A Jenkins, Petur O Heidarsson, Eiríkur Steingrímsson   +13 more
doaj   +1 more source

Mitf Induction by RANKL Is Critical for Osteoclastogenesis

, 2009
Microphthalmia-associated transcription factor (Mitf) regulates the development and function of several cell lineages, including osteoclasts. In this report, we identified a novel mechanism by which RANKL regulates osteoclastogenesis via induction of ...
Ssu-yi Lu, Yi-ling Lin, Mengtao Li
core  

Parthenolide induces MITF-M downregulation and senescence in patient-derived MITF-Mhigh melanoma cell populations

Oncotarget, 2016
The activity of the M isoform of microphthalmia-associated transcription factor (MITF-M) has been attributed to regulation of differentiation, proliferation, survival and senescence of melanoma cells. MITF expression was shown to be antagonized by the activation of transcription factor NF-κB.
Hartman, Mariusz L., Talar, Beata, Sztiller-Sikorska, Malgorzata, Nejc, Dariusz, Czyz, Malgorzata   +4 more
openaire   +3 more sources

TYR promoter transactivation by MITF and LEF-1.

, 2015
A, B Synergism between MITF and LEF-1 and the effect of β-catenin on TYR promoter determined by luciferase activity assay. UACC903 cells were transfected with the TYR promoter-reporter plasmid and the indicated effector plasmid(s). A luciferase assay was
Hongsheng Chen (828171), Lu Jiang (115479), Xueping Wang (509099), Hunjin Luo (828175), Yong Feng (828176), Chufeng He (828173), Lingyun Mei (828172), Jiada Li (692990), Yalan Liu (828170), Zhijie Niu (828174), Jie Sun (74648)   +10 more
core   +1 more source

MITF regulates autophagy and extracellular vesicle cargo in gastrointestinal stromal tumors

Molecular Biomedicine
The role of Microphthalmia-associated Transcription Factor (MITF) in gastrointestinal stromal tumors (GISTs) remains unclear, although previous studies suggest it contributes to tumor growth regulation.
Elizabeth Proaño-Pérez, Eva Serrano-Candelas, Mario Guerrero, David Gómez-Peregrina, Carlos Llorens, Beatriz Soriano, Ana Gámez-Valero, Marina Herrero-Lorenzo, Eulalia Martí, César Serrano, Margarita Martin   +10 more
doaj   +1 more source

TRIM63 Overexpression in FISH-Negative MiTF Family Altered Renal Cell Carcinoma (MiTF RCC)

Modern Pathology
TFE3 and TFEB break-apart fluorescent in situ hybridization (FISH) assays are the "gold standard" for diagnostic confirmation of microphthalmia-associated transcription factor (MiTF) family-altered renal cell carcinoma (MiTF RCC), which includes TFE3-rearranged RCC and TFEB-altered RCC.
Rahul Mannan, Ying-Bei Chen, Xiaoming Wang, Yuping Zhang, Noshad Hosseini, Ankur R. Sangoi, Andres Acosta, Sean R. Williamson, Somnath Mahapatra, Anya K. Chinnaiyan, Jing Hu, Ulka Vaishampayan, Lina Shao, Bryan L. Betz, Annette S. Kim, Xuhong Cao, Fengyun Su, Rui Wang, Pedram Argani, Noah Brown, Satish K. Tickoo, Arul M. Chinnaiyan, Victor E. Reuter, Saravana M. Dhanasekaran, Rohit Mehra   +24 more
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Antagonistic roles for MITF and TFE3 in melanoma plasticity

Cell Reports
Summary Melanoma cells have the ability to switch from a melanocytic and proliferative state to a mesenchymal and invasive state and back again. This plasticity drives intra-tumoral heterogeneity, progression, and therapeutic resistance.
Jeremy Chang, Katelyn R. Campbell-Hanson, Marion Vanneste, Nicholas I. Bartschat, Ryan Nagel, Asdis K Arnadottir, Hong Nhung Vu, Collin Montgomery, Julius Yevdash, Jiarui Jiang, Ardith Bhinu, Annika Helverson, Michael D. Henry, Eiríkur Steingrímsson, Ronald J. Weigel, Robert A. Cornell, Colin Kenny   +16 more
openaire   +4 more sources

Staðsetning MITF í kjarna

, 2014
MITF er basic helix-loop-helix lúsín-zipper umritunarþáttur sem myndar tvenndir við sjálft sig og skyld prótein og gegnir lykilhlutverki í litfrumum þar sem það stýrir tjáningu melaníns í húðinni.
Indriði Einar Reynisson 1990-
core   +1 more source

Supplementary Figure S4 from MITF-High and MITF-Low Cells and a Novel Subpopulation Expressing Genes of Both Cell States Contribute to Intra- and Intertumoral Heterogeneity of Primary Melanoma

, 2017
RNAscope on cultured MITF-high and MITF low ...
Marie Ennen (14915519), Céline Keime (5330), Guillaume Davidson (3727375), Alice Kieny (15004740), Dan Lipsker (5467301), Fanny Margerin-Schaller (15004743), Christelle Thibault-Carpentier (406516), Giovanni Gambi (14935686), Constance Vagne (15004746), Sebastien Coassolo (803716), Irwin Davidson (518811)   +10 more
core   +1 more source

MITF links maturation and quiescence

The Journal of Cell Biology, 2004
The coordination of cell differentiation with exit from the cell division cycle may help to limit organ size and prevent tumor formation. But the mechanism that links these two processes is unknown for most cell types. On page 35, Loercher et al. show that, in melanocytes, the link is the MITF transcription factor.
openaire   +2 more sources