Results 101 to 110 of about 21,203 (224)

A Basic Domain-Derived Tripeptide Inhibits MITF Activity by Reducing its Binding to the Promoter of Genes

, 2021
The keratinocytes in UV-irradiated skin produce and secrete α-melanocyte-stimulating hormone. α-Melanocyte-stimulating hormone upregulates the expression of MITF in melanocytes through the cAMP‒protein kinase A‒CREB signaling pathway.
최지원, Kyoungyul Lee, Minseo Kim, Hyun-Mi Ju, Kyoung-Jin Lee, Yuri Kim, Jang-Hee Hahn, Myoung-Ju Kim, Dong-Hwa Choi, Suree Kim, Jiwon Choi, Dongyoung Lim, Dongmin Kang   +12 more
core   +1 more source

Melanogenesis and MITF expression in primary melanomas: an immunohistochemical study

Surgical and Experimental Pathology
Background The Microphthalmia-associated transcription factor - MITF is a key regulator of melanogenesis, controlling melanin production and pigment phenotype in melanocytes. It also influences cell differentiation, proliferation, and survival.
Karina Munhoz de Paula Alves Coelho, Jaqueline Stall, Rodrigo Blasius, Bruna Louise Silva, Hercílio Fronza Junior, Paulo Henrique Condeixa de França   +5 more
doaj   +1 more source

Cell dynamics on energy landscape: Comparing attractor detection in Boolean network and diffusion‐based models under in silico gene perturbations

Quantitative Biology, Volume 14, Issue 4, December 2026.
Abstract Steady‐state attractor detection differs fundamentally between discrete Boolean network (BN) and continuous diffusion‐based models because they operate on different state spaces and exhibit distinct dynamic behaviors. Here, we propose cell dynamics on energy landscape (CellLand) to systematically compare BN and diffusion‐based approaches for ...
Lingyu Li, Liangjie Sun, Shumin Li, Wai‐Ki Ching, Zhi‐Ping Liu   +4 more
wiley   +1 more source

Marine‐Derived Type I Collagen From Scyliorhinus canicula : Extraction, Characterization, and Biomedical Applications

Journal of Applied Polymer Science, Volume 143, Issue 43, November 15, 2026.
Marine‐derived type I collagen is extracted from Scyliorhinus canicula skin and characterized by physicochemical and morphological analyses. The collagen exhibits excellent biocompatibility, promotes wound healing, reduces inflammatory mediators, and inhibits melanogenesis.
Marwa Rejeb, Aida Lahmar, Arem Selmi, Tahsine Kosksi, Nawres Debbabi, Ghania Hamdi‐Degobert, Leila Chekir‐Ghedira   +6 more
wiley   +1 more source

Regulation of MITF and TFEB

, 2016
The bHLH-LZ transcription factors MITF and TFEB have been implicated in human disease, with their overexpression increasing the risk of developing cancer. The manner in which their access to E-box target motifs is controlled is an important consideration, as it is via binding to these motifs that bHLH-LZ factors mediate changes in gene expression.
openaire   +1 more source

Comprehensive genomic profiling of mucosal melanoma reveals novel fusion transcripts and dysregulation of cell‐cycle, MAPK, and PI3K pathways

The Journal of Pathology, Volume 270, Issue 3, Page 380-395, November 2026.
Abstract Mucosal melanomas (MMs) are rare, aggressive cancers with poor outcomes and limited response to standard therapies. A significant knowledge gap exists regarding their genomic landscape and corresponding druggable targets. This study explores this issue through a multi‐omic analysis, including whole exome‐, RNA‐, and targeted sequencing, of ...
Matilde Monti, Martina Brigida Romanello, Luca Agnelli, Matteo Orlandi, Luca Bertoli, Sara Picinoli, Irene Pezzali, Giulio Eugenio Mandelli, Daniela Medicina, Giovanni Ribaudo, Adele Busico, Elena Conca, Vilma Pellegrini, Piera Balzarini, Daniele Gallucci, Anna Di Matteo, Davide Lombardi, Claudia Ghigna, Giancarlo Pruneri, Alessandra Gianoncelli, Marzia Rossato, William Vermi   +21 more
wiley   +1 more source

Metabolic Profiling of Circulating and Tumour‐Infiltrating T Cells Uncovers Bioenergetic Checkpoints Linked With Immune and Clinical Skewing in Melanoma Patients

Immunology, Volume 179, Issue 3, Page 486-515, November 2026.
In this study, we revealed the disturbed metabolic status of circulating and tumour‐infiltrating CD4+ and CD8+ T cells in melanoma patients through targeted metabolomic and lipidomic (on sorted subsets) and at single cell level using the SCENITH method.
Hugo Brouque, Kareem Mahdy, Stephane Mouret, Sylvain Henry, Camille Niveau, Mélanie Cettour‐Cave, Martin Pelosse, Florence de Fraipont, Julie Charles, Andrei Turtoi, Philippe Saas, Caroline Aspord   +11 more
wiley   +1 more source

Coordinated regulation of Mitf expression and CREB activation.

, 2012
(A) One representative western blot anti-Mitf used to quantify RNA interference efficiency after 24 h of nucleofection. (B) Analysis of Mitf siRNA interference on CREB level of phosphorylation was analyzed measuring CREB level of phosphorylation by ...
Mauro Picardo (92717), Angela Pitisci (177813), Enzo Izzo (177821), Barbara Bellei (177809)   +3 more
core   +1 more source

GENOTYPE – PHENOTYPE CORRELATIONS IN CUTANEOUS MELANOMA PATIENTS CARRIER OF THE MITF p.E318K PATHOGENIC VARIANT

, 2019
Background: The p.E318K variant of the microphthalmia-associated transcription factor (MITF) has been implicated in genetic predisposition to melanoma as an intermediate penetrance allele.
CICCARESE, GIULIA
core   +1 more source

MITF í miðtaugakerfi músarinnar: Tjáning Mitf og markgen í lyktarklumbu

, 2010
Mitf (microphthalmia-associated transcription factor) genið er vel varðveitt og er tjáning þess nauðsynleg fyrir þroskun litfrumna og einnig er það mikilvægt fyrir myndun sortuæxla.
Anna Þóra Pétursdóttir 1984-
core   +1 more source