Results 181 to 190 of about 195,958 (227)

Molecular and functional analysis of the microphthalmia-associated transcription factor (mitf) gene duplicates in red tilapia.

Comparative biochemistry and physiology. Part A, Molecular & integrative physiology, 2022
In vertebrates, the microphthalmia-associated transcription factor (mitf) is at the hub of the melanin synthesis regulation network. However, little information is known about its molecular characterization, expression, location, or function in skin ...
Bingjie Jiang, Lanmei Wang, Mingkun Luo, Wenbin Zhu, J. Fu, Z. Dong   +5 more
semanticscholar   +1 more source

A prepared platelet‐rich plasma extract, namely Self‐Growth Colony, inhibits melanogenesis by down‐regulating microphthalmia‐associated transcription factor in skin melanocyte

Journal of Cosmetic Dermatology, 2021
During melanogenesis, melanocytes produce melanin through enzymatic reactions. Microphthalmia‐associated transcription factor (MITF) is a major regulator in controlling the expressions of melanogenic enzymes tyrosinase (TYR), tyrosine‐related protein‐1 ...
M. S. Guo, Qiyun Wu, Q. Lai, Xiaoyang Wang, Panzhu Bai, K. Fung, T. Dong, K. Tsim   +7 more
semanticscholar   +1 more source

The Transcription Factor Onecut-2 Controls the Microphthalmia-Associated Transcription Factor Gene

Biochemical and Biophysical Research Communications, 2001
Microphthalmia-associated transcription factor (MITF) is essential for melanocyte differentiation. MITF mutations are associated with some cases of Waardenburg syndrome (WS) type 2. WS is a dominantly inherited disease characterized by auditory-pigmentary defects that result from the absence of melanocytes. The lack of mutation in MITF coding sequences
Jacquemin, Patrick, Lannoy, Vincent J., O'Sullivan, James, Read, Andrew, Lemaigre, Frédéric P., Rousseau, Guy G.   +5 more
openaire   +2 more sources

Identification of microphthalmia-associated transcription factor isoforms in dogs

The Veterinary Journal, 2009
Microphthalmia-associated transcription factor (MITF) belongs to the basic helix-loop-helix leucine zipper (bHLH-LZ) family of transcription factors, and plays an important role in the development and differentiation of melanocytes, mast cells, and osteoclasts.
Shuichi, Tsuchida, Takashi, Takizawa, Katsunori, Abe, Masayo, Okamoto, Masahiro, Tagawa   +4 more
openaire   +2 more sources

Microphthalmia‐Associated Transcription Factor in the Wnt Signaling Pathway

Pigment Cell Research, 2003
Microphthalmia‐associated transcription factor (MITF) contains a basic helix‐loop‐helix and leucine‐zipper (bHLH‐LZ) structure and consists of many isoforms with different N‐termini. Melanocyte‐specific MITF isoform (MITF‐M) is of particular interest, because a heterozygous mutation in the MITF gene is associated with Waardenburg syndrome type 2 (WS2 ...
Hideo, Saito, Ken-Ichi, Yasumoto, Kazuhisa, Takeda, Kazuhiro, Takahashi, Hiroaki, Yamamoto, Shigeki, Shibahara   +5 more
openaire   +2 more sources

Licochalcone A restrains microphthalmia‐associated transcription factor expression and growth by activating autophagy in melanoma cells via miR‐142‐3p/Rheb/mTOR pathway

Phytotherapy Research, 2019
Licochalcone A (LCA) was found to possess anticancer effects. This study aimed to investigate the anticancer effects and mechanisms of LCA in melanoma. A375 and B16 melanoma cells were stimulated with LCA, MTT assay was used to assess cell proliferation.
Yuhong Zhang, M. Gao, Li Chen, Lijuan Zhou, Shengnan Bian, Yongmei Lv   +5 more
semanticscholar   +1 more source

Identification of a gene encoding microphthalmia-associated transcription factor and its association with shell color in the clam Meretrix petechialis.

Comparative Biochemistry and Physiology Part B Comparative Biochemistry, 2018
The microphthalmia-associated transcription factor (MITF) is a master regulator of melanocyte development through the direct transcriptional control of related genes, e.g., the phenoloxidase gene.
Shujing Zhang, Hongxia Wang, Jiajia Yu, Fengjuan Jiang, Xin Yue, Baozhong Liu   +5 more
semanticscholar   +1 more source

Structural basis of CBP/p300 recruitment by the microphthalmia-associated transcription factor

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2022
ABSTRACT The microphthalmia-associated transcription factor (MITF) is a master regulator of the melanocyte cell lineage. Aberrant MITF activity can lead to multiple malignancies including skin cancer, where it modulates the proliferation and invasiveness of melanoma. MITF-dependent gene expression requires recruitment
Alexandra D. Brown, Kathleen L. Vergunst, Makenzie Branch, Connor M. Blair, Denis J. Dupré, George S. Baillie, David N. Langelaan   +6 more
openaire   +2 more sources

Rapid Frozen Section Immunostaining of Melanocytes by Microphthalmia-Associated Transcription Factor

The American Journal of Dermatopathology, 2010
Mohs micrographic surgery (MMS) has increasingly become an accepted therapy for melanoma in situ on chronically sun damaged skin (CSDS). However, melanocytes are difficult to locate in frozen material on hematoxylin and eosin. In addition, determining the cut-off between the melanoma and the "atypical melanocytic hyperplasia" in CSDS can be challenging
L Frank, Glass, Renata M, Raziano, Graham S, Clark, H William, Higgins, Sharron, Ladd, Mary H, Lien, Ren, Chen, Basil S, Cherpelis   +7 more
openaire   +2 more sources