Results 161 to 170 of about 73,036 (190)

Microphthalmia‐Associated Transcription Factor in the Wnt Signaling Pathway

Pigment Cell Research, 2003
Microphthalmia‐associated transcription factor (MITF) contains a basic helix‐loop‐helix and leucine‐zipper (bHLH‐LZ) structure and consists of many isoforms with different N‐termini. Melanocyte‐specific MITF isoform (MITF‐M) is of particular interest, because a heterozygous mutation in the MITF gene is associated with Waardenburg syndrome type 2 (WS2 ...
Hideo, Saito, Ken-Ichi, Yasumoto, Kazuhisa, Takeda, Kazuhiro, Takahashi, Hiroaki, Yamamoto, Shigeki, Shibahara   +5 more
openaire   +2 more sources

Identification of microphthalmia-associated transcription factor isoforms in dogs

The Veterinary Journal, 2009
Microphthalmia-associated transcription factor (MITF) belongs to the basic helix-loop-helix leucine zipper (bHLH-LZ) family of transcription factors, and plays an important role in the development and differentiation of melanocytes, mast cells, and osteoclasts.
Shuichi, Tsuchida, Takashi, Takizawa, Katsunori, Abe, Masayo, Okamoto, Masahiro, Tagawa   +4 more
openaire   +2 more sources

Fifteen-year quest for microphthalmia-associated transcription factor target genes

Pigment Cell and Melanoma Research, 2010
Microphthalmia-associated transcription factor (MITF) was initially shown to play a key role in melanocyte differentiation through the direct transcriptional control of TYROSINASE, TYRP1 and DCT genes, encoding the three enzymes involved in melanin synthesis or melanogenesis.
Yann Cheli, Mickael Ohanna, Robert Ballotti   +2 more
exaly   +3 more sources

MicroRNA-218 inhibits melanogenesis by directly suppressing microphthalmia-associated transcription factor expression [PDF]

RNA Biology, 2014
Jin-Fang Zhang, Wei-Mao Wang, Chi-Fai Ng   +2 more
exaly   +2 more sources

Rapid Frozen Section Immunostaining of Melanocytes by Microphthalmia-Associated Transcription Factor

The American Journal of Dermatopathology, 2010
Mohs micrographic surgery (MMS) has increasingly become an accepted therapy for melanoma in situ on chronically sun damaged skin (CSDS). However, melanocytes are difficult to locate in frozen material on hematoxylin and eosin. In addition, determining the cut-off between the melanoma and the "atypical melanocytic hyperplasia" in CSDS can be challenging
L Frank, Glass, Renata M, Raziano, Graham S, Clark, H William, Higgins, Sharron, Ladd, Mary H, Lien, Ren, Chen, Basil S, Cherpelis   +7 more
openaire   +2 more sources

TFE3 Expression in Tumors of the Microphthalmia-Associated Transcription Factor (MiTF) Family

International Journal of Surgical Pathology, 2010
The DNA-binding factor TFE3 is closely related to microphthalmia-associated transcription factor (MiTF) and is over-expressed in alveolar soft part sarcoma (ASPS) and select renal cell carcinomas. Reports of TFE3 expression in PEComa prompted investigation into TFE3 expression among other members of the putative MiTF group of neoplasms.
Brendan C, Dickson, John S, Brooks, Theresa L, Pasha, Paul J, Zhang   +3 more
openaire   +2 more sources

Transcriptional activation of mouse mast cell protease-9 by microphthalmia-associated transcription factor

Biochemical and Biophysical Research Communications, 2003
We explored transcriptional regulation of mouse mast cell protease-9 (mMCP-9), which is implicated in inflammation of the jejunum during helminth infections and tissue remodeling of the uterus during pregnancy. Transcription was positively regulated by microphthalmia-associated transcription factor (MITF), a member of the basic helix-loop-helix-leucine
Masaru Murakami, Teruo Ikeda, Masayuki Funaba   +2 more
exaly   +3 more sources

Identification of a Melanocyte-Type Promoter of the Microphthalmia-Associated Transcription Factor Gene

Biochemical and Biophysical Research Communications, 1996
Microphthalmia-associated transcription factor (MITF), the human homolog of the mouse microphthalmia gene product, regulates melanocyte-specific transcription of the tyrosinase gene that codes for an essential enzyme in melanin biosynthesis. In this study, we have cloned and characterized the human genomic DNA segment containing a melanocyte-type exon ...
N, Fuse, K, Yasumoto, H, Suzuki, K, Takahashi, S, Shibahara   +4 more
openaire   +2 more sources

Microphthalmia-Associated Transcription Factor Is a Critical Transcriptional Regulator of Melanoma Inhibitor of Apoptosis in Melanomas

Cancer Research, 2008
Abstract Melanoma inhibitor of apoptosis (ML-IAP) is a potent inhibitor of apoptosis, which is highly expressed in melanomas and likely contributes to their resistance to chemotherapeutic treatments. Herein, we show that the lineage survival oncogene microphthalmia-associated transcription factor (MITF) is a critical regulator of ML ...
Jasmin N, Dynek, Sara M, Chan, Jinfeng, Liu, Jiping, Zha, Wayne J, Fairbrother, Domagoj, Vucic   +5 more
openaire   +2 more sources

Microphthalmia-associated transcription factor as the molecular target of cadmium toxicity in human melanocytes

Biochemical and Biophysical Research Communications, 2014
Dietary intake of cadmium is inevitable, causing age-related increase in cadmium accumulation in many organs, including hair, choroid and retinal pigment epithelium (RPE). Cadmium has been implicated in the pathogenesis of hearing loss and macular degeneration. The functions of cochlea and retina are maintained by melanocytes and RPE, respectively, and
Wipa, Chantarawong, Kazuhisa, Takeda, Weerapon, Sangartit, Miki, Yoshizawa, Kantimanee, Pradermwong, Shigeki, Shibahara   +5 more
openaire   +2 more sources