Microphthalmia-associated transcription factor

Results 171 to 180 of about 73,036 (190)

Some of the next articles are maybe not open access.

Discovery of a first-in-class degrader for microphthalmia-associated transcription factor (MITF)

European Journal of Medicinal Chemistry
Microphthalmia-associated transcription factor (MITF) is a transcription factor that plays a central role in the pathogenesis, progression, and drug resistance of malignant melanoma. However, MITF has historically been viewed as a challenging drug target, largely due to a lack of deep, well-defined pockets amenable to traditional small-molecule ...
Weizhong Shen +8 more
openaire +2 more sources

Cilostazol promotes production of melanin by activating the microphthalmia-associated transcription factor (MITF)

Biochemical and Biophysical Research Communications, 2014
Cilostazol, a licensed clinical drug for the treatment of intermittent claudication, is a phosphodiesterase (PDE) inhibitor that selectively inhibits PDE3, a cAMP-degrading enzyme, thus elevating levels of intracellular cAMP. It has been reported that pigment production by melanocytes both tans the skin and protects against skin cancers. The effects of
Bo, Wei +4 more
openaire +2 more sources

A CRISPR-Cas12a-based electrochemical biosensor for the detection of microphthalmia-associated transcription factor

Microchimica Acta
A novel electrochemical biosensor that combines the CRISPR-Cas12a system with a gold electrode is reported for the rapid and sensitive detection of microphthalmia-associated transcription factor (MITF). The biosensor consists of a gold electrode modified with DNA1, which contains the target sequence of MITF and is labeled with ferrocene, an ...
Qisheng Luo +8 more
openaire +2 more sources

Microphthalmia-Associated Transcription Factor-Positive Pseudonests in Cutaneous Lupus Erythematosus