Microphthalmia/Transcription Factor E (MiT/TFE) Pathways in Pulmonary Diseases: Current Evidence and Emerging Mechanisms. [PDF]
CellsSingh P, Abor EK, Shi W.
europepmc +1 more source
Bioactive Lipid Mediator Resolvin D5 Suppresses Melanogenesis in α-MSH-Stimulated B16F10 Cells via ROS-Associated p38/β-Catenin/MITF Regulation. [PDF]
J Microbiol BiotechnolChoi HJ +8 more
europepmc +1 more source
Enhanced IFNy response in dedifferentiated melanoma cells is due to chromatin remodeling as revealed by ATAC-seq. [PDF]
Cell Commun SignalSævarsson T +5 more
europepmc +1 more source
Microphthalmia-Associated Transcription Factor: A Differentiation Marker in Uveal Melanoma [PDF]
International Journal of Molecular Sciences, 2023 Microphthalmia-associated transcription factor (MITF) is an important regulator of melanogenesis and melanocyte development. In cutaneous melanoma, MITF loss has been linked to an increased expression of stem cell markers, a shift in epithelial-to-mesenchymal transition (EMT)-related factors, and increased inflammation.
Maria Chiara Gelmi +2 more
exaly +5 more sources
Microphthalmia Associated Transcription Factor Is a Target of the Phosphatidylinositol-3-Kinase Pathway [PDF]
Journal of Investigative Dermatology, 2003 In B16 melanoma cells, cyclic adenosine monophosphate inhibits the phosphatidylinositol-3-kinase and the phosphatidylinositol-3-kinase inhibitor, LY294002, stimulates melanogenesis. However, the molecular mechanisms, by which phosphatidylinositol-3-kinase inhibition increases melanogenesis remained to be identified. In this study, we show that LY294002
Mehdi Khaled +2 more
exaly +6 more sources
The Transcription Factor Onecut-2 Controls the Microphthalmia-Associated Transcription Factor Gene [PDF]
Biochemical and Biophysical Research Communications, 2001 Microphthalmia-associated transcription factor (MITF) is essential for melanocyte differentiation. MITF mutations are associated with some cases of Waardenburg syndrome (WS) type 2. WS is a dominantly inherited disease characterized by auditory-pigmentary defects that result from the absence of melanocytes. The lack of mutation in MITF coding sequences
Patrick Jacquemin +2 more
exaly +4 more sources
Modulation of Microphthalmia-associated Transcription Factor Gene Expression Alters Skin Pigmentation [PDF]
Journal of Investigative Dermatology, 2002 The microphthalmia-associated transcription factor is implicated in melanocyte development and in the regulation of melanogenesis. Microphthalmia-associated transcription factor is thought to bind to the M-box promoter elements of tyrosinase, tyrosinase-related protein-1 and dopachrome tautomerase/tyrosinase-related protein-2 and transactivate these ...
M Kizoulis +2 more
exaly +5 more sources
Microphthalmia‐associated transcription factor in melanoma development and MAP‐kinase pathway targeted therapy [PDF]
Pigment Cell and Melanoma Research, 2015 Malignant melanoma is a neoplasm of melanocytes, and the microphthalmia-associated transcription factor (MITF) is essential for the existence of melanocytes.
Claudia Wellbrock, Imanol Arozarena
exaly +4 more sources
CBP/p300 as a co-factor for the Microphthalmia transcription factor [PDF]
Oncogene, 1997 The Microphthalmia basic-Helix-Loop-Helix-Leucine Zipper (bHLH-LZ) transcription factor (Mi) plays a crucial role in the genesis of melanocytes; mice deficient for a functional (Microphthalmia) gene product lack all pigment cells.
Tony Kouzarides +2 more
exaly +2 more sources
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Structural basis of CBP/p300 recruitment by the microphthalmia-associated transcription factor
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2022ABSTRACT The microphthalmia-associated transcription factor (MITF) is a master regulator of the melanocyte cell lineage. Aberrant MITF activity can lead to multiple malignancies including skin cancer, where it modulates the proliferation and invasiveness of melanoma. MITF-dependent gene expression requires recruitment
Alexandra D. Brown +6 more
openaire +2 more sources