Results 1 to 10 of about 24,556,719 (242)

An eighteen-organ microphysiological system coupling a vascular network and excretion system for drug discovery [PDF]

Microsystems & Nanoengineering
Physiological supporting systems, such as the vascular network and excretion system, are crucial for the effective functioning of organs. This study demonstrates that when a body-on-a-chip microdevice is coupled with miniaturized physiological support ...
Jing Wang, Huixue Zhang, Yueyang Qu, Yang Yang, Shuhui Xu, Zhenni Ji, Yuxiu Wang, Xiuli Zhang, Yong Luo   +8 more
doaj   +3 more sources

Dynamic microphysiological system chip platform for high-throughput, customizable, and multi-dimensional drug screening [PDF]

Bioactive Materials
Spheroids and organoids have attracted significant attention as innovative models for disease modeling and drug screening. By employing diverse types of spheroids or organoids, it is feasible to establish microphysiological systems that enhance the ...
Yuxuan Zhu, Deming Jiang, Yong Qiu, Xin Liu, Yuhan Bian, Shichao Tian, Xiandi Wang, K. Jimmy Hsia, Hao Wan, Liujing Zhuang, Ping Wang   +10 more
doaj   +3 more sources

Modeling lung endothelial dysfunction in sepsis‐associated ARDS using a microphysiological system [PDF]

Physiological Reports
Endothelial dysfunction is a critical feature of acute respiratory distress syndrome (ARDS) associated with higher disease severity and worse outcomes. Preclinical in vivo models of sepsis and ARDS have failed to yield useful therapies in humans, perhaps
Nai‐Wen Liang, Carole Wilson, Brooke Davis, Ian Wolf, Tonela Qyli, Joy Moy, David J. Beebe, Lynn M. Schnapp, Sheena C. Kerr, Hilary E. Faust   +9 more
doaj   +3 more sources

Development of a kidney microphysiological system hardware platform for microgravity studies [PDF]

npj Microgravity
Determining the physiological effects of microgravity on the human kidney is limited to relatively insensitive tests of biofluids (blood and urine) that do not return abnormal results until more than 50% of kidney function is lost.
Kendan A. Jones-Isaac, Kevin A. Lidberg, Catherine K. Yeung, Jade Yang, Jacelyn Bain, Micaela Ruiz, Greta Koenig, Paul Koenig, Stefanie Countryman, Jonathan Himmelfarb, Edward J. Kelly   +10 more
doaj   +3 more sources

Democratizing Organ-On-Chip Technologies With a Modular, Reusable, and Perfusion-Ready Microphysiological System. [PDF]

Adv Healthc Mater
Organ-on-chip (OOC) technologies, also called microphysi-ological systems (MPS), offer dynamic microenvironments that improve upon static culture systems, yet widespread adoption has been hindered by fabrication complexity, reliance on poly ...
Minahan DJ, Nelson KM, Ribeiro F, Ferrick BJ, Zurzolo AM, Byers K, Mckeown V, Gleghorn JP.   +7 more
europepmc   +2 more sources

Vascular Microphysiological System for Investigating Endothelial Barrier Function During Organ Preservation and Reperfusion. [PDF]

Small
Endothelial cell damage after cold preservation and reperfusion injury causes deterioration of the endothelial barrier and ultimately results in edema, leading to transplant failure.
Kim Y, Goswami I, Gill E, Mahmoodi SR, Consiglio AN, Velazquez J, Nieman G, Alburo AAA, Woods B, Ellis BW, Filz von Reiterdank I, Uygun K, Uygun BE, Rubinsky B, Healy KE.   +14 more
europepmc   +2 more sources

Porcine intestinal organoids cultured in an organ-on-a-chip microphysiological system. [PDF]

Biochem Biophys Rep
Preclinical studies are a vital component of pharmaceutical development and improvements in the predictive value of in vitro studies are essential. Organ-on-a-chip in vitro models are a recent advancement in the pursuit of improved reproduction of in ...
Bacon J, Kitchel H, Stutz J, Chen JH, Smith A, Van Horn RD, Moreland C, Abraham T, Baker T, Aihara E, Hillgren K.   +10 more
europepmc   +2 more sources

Drug treatment alters performance in a neural microphysiological system of information processing. [PDF]

Commun Biol
Assessment of pharmacological intervention on in vitro neural systems often emphasizes molecular and structural changes. However, neural systems fundamentally process and act on information.
Watmuff B, Habibollahi F, Desouza C, Khajehnejad M, Loeffler A, Baranes K, Poulin N, Kotter M, Kagan BJ.   +8 more
europepmc   +2 more sources

An engineered human placental organoid microphysiological system in a vascular niche to model viral infection. [PDF]

Commun Biol
The placenta forms the maternal-fetal interface to protect the developing fetus from xenobiotics or pathogens. However, the understanding of complex placental features and responses to pathogens are hindered due to the lack of near-physiological models ...
Wang Y, Guo Y, Wang P, Liu J, Zhang X, Liu Q, Wei L, Xu C, Qin J.   +8 more
europepmc   +2 more sources

Engineering the bone metastatic prostate cancer niche through a microphysiological system to report patient-specific treatment response. [PDF]

Commun Biol
Bone is the most common site of prostate cancer metastasis, leading to significant morbidity, treatment resistance, and mortality. A major challenge in understanding treatment response is the complex, bone metastatic niche.
Sánchez-de-Diego C, Yada RC, Sethakorn N, Geiger PG, Ding AB, Heninger E, Ahmed F, Virumbrales-Muñoz M, Lupsa N, Bartels E, Stewart K, Ponik SM, Sharifi MN, Lang JM, Beebe DJ, Kerr SC.   +15 more
europepmc   +2 more sources