Results 101 to 110 of about 24,556,719 (242)
Microphysiological system for heart tissue - going from 2D to 3D culture
Current Directions in Biomedical Engineering, 2019 Recently, we could demonstrate positive effects of microfluidic cultivation conditions on maturation of cardiomyocytes derived from human induced pluripotent stem cells (iPS-CMs) in a 2D model.
Busek Mathias +6 more
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An In Vitro Microfluidic Alveolus Model to Study Lung Biomechanics
Frontiers in Bioengineering and Biotechnology, 2022 The gas exchange units of the lung, the alveoli, are mechanically active and undergo cyclic deformation during breathing. The epithelial cells that line the alveoli contribute to lung function by reducing surface tension via surfactant secretion, which ...
Vardhman Kumar +9 more
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Ten Quick Tips for Using a Raspberry Pi
, 2019 Much of biology (and, indeed, all of science) is becoming increasingly computational. We tend to think of this in regards to algorithmic approaches and software tools, as well as increased computing power.
Fletcher, Anthony C, Mura, Cameron
core +1 more source
Organs-on-Chips in Drug Development: The Importance of Involving Stakeholders in Early Health Technology Assessment [PDF]
, 2016 Organs-on-chips are three-dimensional, microfluidic cell culture systems that simulate the function of tissues and organ subunits. Organ-on-chip systems are expected to contribute to drug candidate screening and the reduction of animal tests in ...
Hummel, J. Marjan +6 more
core +3 more sources
Advanced Healthcare Materials, EarlyView.AngioPlate384 is a 384‐well open‐top platform that automates production of more than 100 miniaturized, perfusable blood vessels embedded in hydrogel and supported by stromal cells. Stromal‐endothelial co‐culture strengthens blood vessel barrier function and yields responses useful for translational planning. Scalable and automation‐ready, it suits drug
Dawn S. Y. Lin +14 more
wiley +1 more source
Scientific ReportsHepatic spheroids are of high interest in basic research, drug discovery and cell therapy. Existing methods for spheroid culture present advantages and drawbacks.
Lucile Rabiet +9 more
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The Development of Controllable Magnetic Driven Microphysiological System
Frontiers in Cell and Developmental Biology, 2019 Current research has enabled the use of microphysiological systems and creation of models for alveolar and pulmonary diseases. However, bottlenecks remain in terms of medium- and long-term regulation of cell cultures and their functions in microchannel ...
Jia-Wei Yang +19 more
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, 2013 Interest in “engineering liver” arises from multiple communities: therapeutic replacement; mechanistic models of human processes; and drug safety and efficacy studies.
Griffith, Linda G. +2 more
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Advanced Healthcare Materials, EarlyView.To dissect how mechanical forces influence intestinal physiology, we developed a stretchable 3D colon‐on‐chip that integrates tunable topography, stiffness and peristalsis‐like motion within a physiologically relevant microenvironment. We showed that stretching is a dominant factor governing epithelial behavior, markedly enhancing proliferation and ...
Moencopi Bernheim‐Dennery +10 more
wiley +1 more source
Foreword—Microphysiological Systems
Microphysiological Systems, 2017 It has been increasingly realized that the conventional planar cell cultures do not necessarily reproduce human physiology in vitro due to their limited ability to reproduce the structural and functional complexity of the in vivo counterparts, often resulting in biased outcomes of biological and pharmacological interrogations.
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