Results 11 to 20 of about 24,556,719 (242)

Assessment of drug permeability using a small airway microphysiological system [PDF]

Frontiers in Pharmacology
BackgroundThere is a need to reliably predict the permeability of inhaled compounds during the development of new and generic drugs. A small airway microphysiological system (MPS) that can recapitulate the pulmonary air-liquid interface (ALI) with ...
Robert M. Geiger, Shekh M. Rahman, Md Shadiqur Rashid Roni, Catherine Sullenberger, Sabyasachy Mistry, Katherine Shea, Isra Tariq, Omnia A. Ismaiel, Murali K. Matta, Paula L. Hyland, Sasha Berdichevski, Sasha Berdichevski, Alexandre J. S. Ribeiro, Ksenia Blinova, Wenlei Jiang, Ross L. Walenga, Bryan Newman, Donna A. Volpe, Kevin A. Ford   +18 more
doaj   +2 more sources

Digital twin-enhanced three-organ microphysiological system for studying drug pharmacokinetics in pregnant women. [PDF]

Front Pharmacol
Background Pregnant women represent a vulnerable group in pharmaceutical research due to limited knowledge about drug metabolism and safety of commonly used corticosteroids like prednisone due to ethical and practical constraints.
Graf K, Murrieta-Coxca JM, Vogt T, Besser S, Geilen D, Kaden T, Bothe AK, Morales-Prieto DM, Amiri B, Schaller S, Kaufmann L, Raasch M, Ammar RM, Maass C.   +13 more
europepmc   +2 more sources

A Microphysiological System for Studying Nonalcoholic Steatohepatitis [PDF]

Hepatology Communications, 2020
Nonalcoholic steatohepatitis (NASH) is the most severe form of nonalcoholic fatty liver disease (NAFLD), which to date has no approved drug treatments. There is an urgent need for better understanding of the genetic and molecular pathways that underlie ...
Tomasz Kostrzewski, Paloma Maraver, Larissa Ouro‐Gnao, Ana Levi, Sophie Snow, Alina Miedzik, Krista Rombouts, David Hughes   +7 more
doaj   +4 more sources

Modeling Toxoplasma gondii-gut early interactions using a human microphysiological system. [PDF]

PLoS Negl Trop Dis
Oral transmission of parasites via environmentally resistant cyst stages in contaminated food or water is a common route of human infection, but there are no effective vaccines available for any enteric parasitic infection. Our knowledge of parasite cyst
Ramírez-Flores CJ, Hryckowian ND, Gale AN, Babatunde KA, Lares M, Beebe DJ, Kerr SC, Knoll LJ.   +7 more
europepmc   +2 more sources

A microphysiological system for studying barrier health of live tissues in real time. [PDF]

Commun Eng
Epithelial cells create barriers that protect many different components in the body from their external environment. Increased gut barrier permeability (leaky gut) has been linked to several chronic inflammatory diseases. Understanding the cause of leaky
Way R, Templeton H, Ball D, Cheng MH, Tobet SA, Chen T.   +5 more
europepmc   +3 more sources

Development of a novel gut microphysiological system that facilitates assessment of drug absorption kinetics in gut. [PDF]

Sci Rep
There is an urgent need for novel methods that can accurately predict intestinal absorption of orally administered drugs in humans. This study aimed to evaluate the potential of a novel gut microphysiological system (MPS), gut MPS/Fluid3D-X, to assess ...
Imaoka T, Onuki-Nagasaki R, Kimura H, Tai K, Ishii M, Nozue A, Kaisaki I, Hoshi M, Watanabe K, Maeda K, Kamizono T, Yoshioka T, Fujimoto T, Satoh T, Nakamura H, Ando O, Kusuhara H, Ito Y.   +17 more
europepmc   +2 more sources

Adipocyte inflammation is the primary driver of hepatic insulin resistance in a human iPSC-based microphysiological system. [PDF]

Nat Commun
Interactions between adipose tissue, liver and immune system are at the center of metabolic dysfunction-associated steatotic liver disease and type 2 diabetes.
Qi L, Groeger M, Sharma A, Goswami I, Chen E, Zhong F, Ram A, Healy K, Hsiao EC, Willenbring H, Stahl A.   +10 more
europepmc   +2 more sources

A Microphysiological System with an Anaerobic Air‐Liquid Interface and Functional Mucus Layer for Coculture of Intestinal Bacteria and Primary Human Colonic Epithelium

Advanced Materials Interfaces
Coculture of intestinal bacteria with primary human intestinal epithelium provides a valuable tool for investigating host‐colon bacterial interactions and for testing and screening therapeutics.
Raehyun Kim, Nancy L. Allbritton
doaj   +2 more sources

A Pumpless, High-Throughput Microphysiological System to Mimic Enteric Innervation of Duodenal Epithelium and the Impact on Barrier Function. [PDF]

Adv Funct Mater
Enteric neurons are critical in maintaining organ homeostasis within the small intestine, and their dysregulation are implicated in gastrointestinal disorders and neurodegenerative diseases.
Kaiser KN, Snyder JR, Koppes RA, Koppes AN.   +3 more
europepmc   +2 more sources

Human in vitro endometriosis microphysiological system

Current Directions in Biomedical Engineering
Endometriosis is a debilitating condition that causes severe pain and infertility, among other morbidities. It affects 10% of reproductive-aged women worldwide and poses a significant public health challenge due to its prevalence and the lack of ...
Pinheiro Marques Joao, Verdes Nastasia, Nikles Laetitia, Mendes Ferreira Vincent, Sivakumar Shaginth, Roux Adrien   +5 more
doaj   +2 more sources