Results 21 to 30 of about 24,556,719 (242)

Evaluation of Perfusion Cell Culture Conditions in a Double-Layered Microphysiological System Using AI-Assisted Morphological Analysis [PDF]

Micromachines
In recent years, microphysiological systems (MPS) using microfluidic technology as a new in vitro experimental system have shown promise as an alternative to animal experiments in the development of drugs, especially in the field of drug discovery, and ...
Naokata Kutsuzawa, Tomomi Goto, Hiroko Nakamura, Miwa Maeda, Masaki Kinehara, Junko Sakagami, Hiroshi Kimura   +6 more
doaj   +2 more sources

Physiological platelet aggregation assay to mitigate drug-induced thrombocytopenia using a microphysiological system. [PDF]

Sci Rep
Developing a reliable method to predict thrombocytopenia is imperative in drug discovery. Here, we establish an assay using a microphysiological system (MPS) to recapitulate the in-vivo mechanisms of platelet aggregation and adhesion.
Harada K, Wenlong W, Shinozawa T.
europepmc   +2 more sources

An in vitro multi-organ microphysiological system (MPS) to investigate the gut-to-brain translocation of neurotoxins. [PDF]

Biomicrofluidics
The death of dopamine-producing neurons in the substantia nigra in the base of the brain is a defining pathological feature in the development of Parkinson's disease (PD).
Jones EJ, Skinner BM, Parker A, Baldwin LR, Greenman J, Carding SR, Funnell SGP.   +6 more
europepmc   +2 more sources

Microphysiological system with integrated sensors to study the effect of pulsed electric field. [PDF]

Sci Rep
This study focuses on the use of pulsed electric fields (PEF) in microfluidics for controlled cell studies. The commonly used material for soft lithography, polydimethylsiloxane (PDMS), does not fully ensure the necessary chemical and mechanical ...
Bakute N, Andriukonis E, Kasperaviciute K, Dobilas J, Sapurov M, Mozolevskis G, Stirke A.   +6 more
europepmc   +2 more sources

Rapid Biofabrication of an Advanced Microphysiological System Mimicking Phenotypical Heterogeneity and Drug Resistance in Glioblastoma. [PDF]

Adv Healthc Mater
Microphysiological systems (MPSs) reconstitute tissue interfaces and organ functions, presenting a promising alternative to animal models in drug development.
Pun S, Prakash A, Demaree D, Krummel DP, Sciumè G, Sengupta S, Barrile R.   +6 more
europepmc   +2 more sources

Development of a Novel Microphysiological System for Peripheral Neurotoxicity Prediction Using Human iPSC-Derived Neurons with Morphological Deep Learning [PDF]

Toxics
A microphysiological system (MPS) is an in vitro culture technology that reproduces the physiological microenvironment and functionality of humans and is expected to be applied for drug screening.
Xiaobo Han, Naoki Matsuda, Makoto Yamanaka, Ikuro Suzuki   +3 more
doaj   +2 more sources

RCAN1.4 regulates tumor cell engraftment and invasion in a thyroid cancer to lung metastasis-on-a-chip microphysiological system. [PDF]

Biofabrication
Progressive metastasis is the primary cause of cancer-related deaths. It has been recognized that many cancers are characterized by long periods of stability followed by subsequent progression.
Nairon KG, Nigam A, Khanal T, Rodriguez MA, Rajan N, Anderson SR, Ringel MD, Skardal A.   +7 more
europepmc   +2 more sources

Engineering a Human Pluripotent Stem Cell-Based in vitro Microphysiological System for Studying the Metformin Response in Aortic Smooth Muscle Cells

Frontiers in Bioengineering and Biotechnology, 2021
Aortic aneurysm is a common cardiovascular disease characterised by continuous dilation of the aorta, and this disease places a heavy burden on healthcare worldwide.
Nan Chen, Nan Chen, Mieradilijiang Abudupataer, Mieradilijiang Abudupataer, Sisi Feng, Shichao Zhu, Shichao Zhu, Wenrui Ma, Wenrui Ma, Jun Li, Jun Li, Hao Lai, Hao Lai, Kai Zhu, Kai Zhu, Chunsheng Wang, Chunsheng Wang   +16 more
doaj   +1 more source

Gastrointestinal microphysiological systems [PDF]

Experimental Biology and Medicine, 2017
Gastrointestinal diseases are a significant health care and economic burden. Prevention and treatment of these diseases have been limited by the available human biologic models. Microphysiological systems comprise organ-specific human cultures that recapitulate many structural, biological, and functional properties of the organ in smaller scale ...
Sarah E, Blutt, James R, Broughman, Winnie, Zou, Xi-Lei, Zeng, Umesh C, Karandikar, Julie, In, Nicholas C, Zachos, Olga, Kovbasnjuk, Mark, Donowitz, Mary K, Estes   +9 more
openaire   +2 more sources

Modeling immunity in microphysiological systems

Experimental Biology and Medicine, 2023
There is a need for better predictive models of the human immune system to evaluate safety and efficacy of immunomodulatory drugs and biologics for successful product development and regulatory approvals. Current in vitro models, which are often tested in two-dimensional (2D) tissue culture polystyrene, and preclinical animal models fail to fully ...
Brian J Kwee, Xiaoqing Li, Xinh-Xinh Nguyen, Courtney Campagna, Johnny Lam, Kyung E Sung   +5 more
openaire   +2 more sources