Gravity-Based Flow Efficient Perfusion Culture System for Spheroids Mimicking Liver Inflammation
Biomedicines, 2021 The spheroid culture system provides an efficient method to emulate organ-specific pathophysiology, overcoming the traditional two-dimensional (2D) cell culture limitations.
Young-Su Kim +5 more
doaj +1 more source
Modeling inflammation and oxidative stress in gastrointestinal disease development using novel organotypic culture systems. [PDF]
, 2013 Gastroesophageal reflux disease (GERD), Barrett's esophagus (BE), graft-versus-host disease (GVHD), and inflammatory bowel diseases such as ulcerative colitis and Crohn's disease are common human gastrointestinal diseases that share inflammation as a key
Bortner, James D +6 more
core +2 more sources
Integration of systems biology with organs-on-chips to humanize therapeutic development [PDF]
, 2017 "Mice are not little people" - a refrain becoming louder as the gaps between animal models and human disease become more apparent. At the same time, three emerging approaches are headed toward integration: powerful systems biology analysis of cell-cell ...
Chen, Wen Li +6 more
core +1 more source
Interconnected Microphysiological Systems for Quantitative Biology and Pharmacology Studies [PDF]
, 2018 Microphysiological systems (MPSs) are in vitro models that capture facets of in vivo organ function through use of specialized culture microenvironments, including 3D matrices and microperfusion.
Brij M. Bhushan +37 more
core +2 more sources
Physiome-on-a-Chip: The Challenge of “Scaling” in Design, Operation, and Translation of Microphysiological Systems [PDF]
, 2015 Scaling of a microphysiological system (MPS) or physiome-on-a-chip is arguably two interrelated, modeling-based activities: on-platform scaling and in vitro-in vivo translation.
Cirit, Murat +2 more
core +1 more source
Quantitative Systems Pharmacology Approaches Applied to Microphysiological Systems (MPS): Data Interpretation and Multi-MPS Integration [PDF]
, 2015 Our goal in developing Microphysiological Systems (MPS) technology is to provide an improved approach for more predictive preclinical drug discovery via a highly integrated experimental/computational paradigm.
Cilfone, Nicholas A. +10 more
core +1 more source
A microphysiological system model of therapy for liver micrometastases [PDF]
, 2014 Metastasis accounts for almost 90% of cancer-associated mortality. The effectiveness of cancer therapeutics is limited by the protective microenvironment of the metastatic niche and consequently these disseminated tumors remain incurable.
Borenstein, Jeffrey T. +12 more
core +1 more source
Rapid Prototyping of Multilayer Microphysiological Systems
ACS Biomaterials Science & Engineering, 2020 Microfluidic organs-on-chips aim to realize more biorelevant in vitro experiments compared to traditional two-dimensional (2D) static cell culture. Often such devices are fabricated via poly(dimethylsiloxane) (PDMS) soft lithography, which offers benefits (e.g., high feature resolution) along with drawbacks (e.g., prototyping time/costs).
Sanjin Hosic +9 more
openaire +3 more sources
Human Mesenchymal Stem Cell‐Derived Miniature Joint System for Disease Modeling and Drug Testing
Advanced Science, 2022 Diseases of the knee joint such as osteoarthritis (OA) affect all joint elements. An in vitro human cell‐derived microphysiological system capable of simulating intraarticular tissue crosstalk is desirable for studying etiologies/pathogenesis of joint ...
Zhong Li +22 more
doaj +1 more source
Integrated Gut and Liver Microphysiological Systems for Quantitative In Vitro Pharmacokinetic Studies [PDF]
, 2017 Investigation of the pharmacokinetics (PK) of a compound is of significant importance during the early stages of drug development, and therefore several in vitro systems are routinely employed for this purpose.
Chen, Wen Li +5 more
core +2 more sources