The Dormancy Dilemma: Quiescence versus Balanced Proliferation [PDF]
, 2013 Metastatic dissemination with subsequent clinical outgrowth leads to the greatest part of morbidity and mortality from most solid tumors. Even more daunting is that many of these metastatic deposits silently lie undetected, recurring years to decades ...
Griffith, Linda G. +3 more
core +2 more sources
Microphysiological system design: simplicity is elegance
Current Opinion in Biomedical Engineering, 2020 Design parameters for microphysiological systems (MPS) are driven by the need for new tools to answer questions focusing on human physiology in a robust and reliable manner. Within this perspective, engineering benchmarks and principles are identified to guide the construction of new devices in the MPS field, with emphasis placed on the design ...
Samuel S. Hinman +5 more
openaire +3 more sources
Microphysiologic systems in female reproductive biology [PDF]
Experimental Biology and Medicine, 2017 Microphysiologic systems (MPS), including new organ-on-a-chip technologies, recapitulate tissue microenvironments by employing specially designed tissue or cell culturing techniques and microfluidic flow. Such systems are designed to incorporate physiologic factors that conventional 2D or even 3D systems cannot, such as the multicellular dynamics of a
Alexandria N, Young +3 more
openaire +2 more sources
Lung epithelial cells induce both phenotype alteration and senescence in breast cancer cells [PDF]
, 2015 Purpose: The lung is one of the most common sites of breast cancer metastasis. While metastatic seeding is often accompanied by a dormancy-promoting mesenchymal to epithelial reverting transitions (MErT), we aimed to determine whether lung epithelial ...
Clark, AM +3 more
core +7 more sources
Maximizing the Impact of Microphysiological Systems with in Vitro–in Vivo Translation [PDF]
, 2018 Microphysiological systems (MPS) hold promise for improving therapeutic drug approval rates by providing more physiological, human-based, in vitro assays for preclinical drug development activities compared to traditional in vitro and animal models. Here,
Cirit, Murat, Stokes, Cynthia L.
core +1 more source
Microphysiological Systems for Neurodegenerative Diseases in Central Nervous System [PDF]
Micromachines, 2020 Neurodegenerative diseases are among the most severe problems in aging societies. Various conventional experimental models, including 2D and animal models, have been used to investigate the pathogenesis of (and therapeutic mechanisms for) neurodegenerative diseases.
Mihyeon Bae +3 more
openaire +4 more sources
In vitro tissue microarrays for quick and efficient spheroid characterisation [PDF]
, 2018 Three-dimensional in vitro microphysiological cultures, such as spheroids and organoids, promise increased patient relevance and therapeutic predictivity compared to reductionist cell monolayers.
A. M. Grabowska, D. P. Ivanov, Subik K.
core +2 more sources
Autologous induced pluripotent stem cell-derived four-organ-chip
Future Science OA, 2019 Microphysiological systems play a pivotal role in progressing toward a global paradigm shift in drug development. Here, we designed a four-organ-chip interconnecting miniaturized human intestine, liver, brain and kidney equivalents. All four organ models
Anja Patricia Ramme +17 more
doaj +1 more source
Chip-based human liver-intestine and liver-skin co-culture : A first step toward systemic repeated dose substance testing in vitro [PDF]
, 2015 Systemic repeated dose safety assessment and systemic efficacy evaluation of substances are currently carried out on laboratory animals and in humans due to the lack of predictive alternatives.
Ayehunie, Seyoum +12 more
core +1 more source
Computational fluid dynamic analysis of bioprinted self-supporting perfused tissue models [PDF]
, 2020 Natural tissues are incorporated with vasculature, which is further integrated with a cardiovascular system responsible for driving perfusion of nutrient‐rich oxygenated blood through the vasculature to support cell metabolism within most cell‐dense ...
Bonewald, Lynda F. +8 more
core +1 more source