Results 61 to 70 of about 24,556,719 (242)
Microphysiological Systems: Design, Fabrication, and Applications
ACS Biomaterials Science & Engineering, 2020 Microphysiological systems, including organoids, 3-D printed tissue constructs and organ-on-a-chips (organ chips), are physiologically relevant in vitro models and have experienced explosive growth in the past decades. Different from conventional, tissue culture plastic-based in vitro models or animal models, microphysiological systems recapitulate key
Kai Wang +6 more
openaire +3 more sources
Gut Microbes, 2020 A microengineered human gut-on-a-chip has demonstrated intestinal physiology, three-dimensional (3D) epithelial morphogenesis, and longitudinal host-microbiome interactions in vitro.
Woojung Shin +2 more
doaj +1 more source
, 2018 © 2017 The liver plays critical roles in both homeostasis and pathology. It is the major site of drug metabolism in the body and, as such, a common target for drug-induced toxicity and is susceptible to a wide range of diseases.
Beckwitt, Colin H. +6 more
core +1 more source
Patient‐Derived Microphysiological Systems for Precision Medicine
Advanced Healthcare Materials, 2023 AbstractPatient‐derived microphysiological systems (P‐MPS) have emerged as powerful tools in precision medicine that provide valuable insight into individual patient characteristics. This review discusses the development of P‐MPS as an integration of patient‐derived samples, including patient‐derived cells, organoids, and induced pluripotent stem cells,
Jihoon Ko +3 more
openaire +2 more sources
Demineralized bone bioinks with enhanced odontogenic differentiation: Synthesis and characterization
Polymer TestingWe developed a photocrosslinkable hydrogel, DbpGMA, by chemically functionalizing demineralized bone powder (DBP) with glycidyl methacrylate (GMA). Bone particles smaller than 90 μm effectively preserved the collagenous matrix after demineralization ...
Sudarshini Nath +12 more
doaj +1 more source
Engineering Organ-on-a-Chip to Accelerate Translational Research
Micromachines, 2022 We guide the use of organ-on-chip technology in tissue engineering applications. Organ-on-chip technology is a form of microengineered cell culture platform that elaborates the in-vivo like organ or tissue microenvironments.
Jihoon Ko +4 more
doaj +1 more source
Profiling paracrine interactions between hypoxic and normoxic skeletal muscle tissue in a microphysiological system fabricated from 3D printed components. [PDF]
Lab ChipRexius-Hall ML +4 more
europepmc +2 more sources
HeLiVa platform: integrated heart-liver-vascular systems for drug testing in human health and disease [PDF]
, 2015 Our project team is developing an integrated microphysiological platform with functionally connected vascular, liver and cardiac microtissues derived from a single line of human pluripotent stem cells.
Bhatia, Sangeeta +3 more
core +1 more source
Organoids pharmacology and toxicology
EngMedicineModel evolution is crucial for understanding the effects and safety of drugs in pharmacological and toxicological research. Traditional cell lines and animal models have contributed significantly to drug development.
Jie Sun +7 more
doaj +1 more source
A four-organ-chip for interconnected long-term co-culture of human intestine, liver, skin and kidney equivalents [PDF]
, 2015 Systemic absorption and metabolism of drugs in the small intestine, metabolism by the liver as well as excretion by the kidney are key determinants of efficacy and safety for therapeutic candidates. However, these systemic responses of applied substances
Bauer, Sophie +13 more
core +1 more source