Results 1 to 10 of about 24,554,140 (185)

Bioengineering ethics for the age of microphysiological systems [PDF]

Frontiers in Bioengineering and Biotechnology
The development of microphysiological systems (MPS) is pushing ethical standards in biomedical research to a breaking point. This article argues that only a perspective drawing from engineering ethics will be able to address the new challenges raised by ...
Maxence Gaillard, Maxence Gaillard
doaj   +3 more sources

Leveraging microphysiological systems to expedite understanding of host-parasite interactions. [PDF]

PLoS Pathogens
Microphysiological systems (MPS) replicate the dynamic interactions between cells, tissues, and fluids. They have emerged as transformative tools for biology and have been increasingly applied to host-parasite interactions.
Maria Zorrinho-Almeida, Jorge de-Carvalho, Maria Bernabeu, Sara Silva Pereira   +3 more
doaj   +3 more sources

Microphysiological systems as models for immunologically ‘cold’ tumors [PDF]

Frontiers in Cell and Developmental Biology
The tumor microenvironment (TME) is a diverse milieu of cells including cancerous and non-cancerous cells such as fibroblasts, pericytes, endothelial cells and immune cells.
Daniela Gaebler, Stephanie J. Hachey, Christopher C. W. Hughes, Christopher C. W. Hughes   +3 more
doaj   +3 more sources

Human neural organoid microphysiological systems show the building blocks necessary for basic learning and memory. [PDF]

Commun Biol
Brain Microphysiological Systems, including neural organoids derived from human induced pluripotent stem cells, offer a unique lens to study the intricate workings of the human brain.
Alam El Din DM, Moenkemoeller L, Loeffler A, Habibollahi F, Schenkman J, Mitra A, van der Molen T, Ding L, Laird J, Schenke M, Johnson EC, Kagan BJ, Hartung T, Smirnova L.   +13 more
europepmc   +3 more sources

Microphysiological Systems of Lymphatics and Immune Organs. [PDF]

Adv Healthc Mater
Microphysiological systems (MPS) that incorporate engineered blood vasculatures have enabled new opportunities to study human physiology and disease, offering platforms for drug development, tissue modeling, and regenerative medicine. However, most human
Jain I, Singh A, García AJ.
europepmc   +2 more sources

Natural Polymer-Based Hydrogel Platforms for Organoid and Microphysiological Systems: Mechanistic Insights and Translational Perspectives. [PDF]

Polymers (Basel)
Organoids and microphysiological systems (MPSs) have emerged as physiologically relevant platforms that recapitulate key structural and functional features of human organs, tissues, and microenvironments.
Cho Y, You J, Lee JH.
europepmc   +2 more sources

Organic Bioelectronics in Microphysiological Systems: Bridging the Gap Between Biological Systems and Electronic Technologies. [PDF]

Biosensors (Basel)
The growing burden of degenerative, cardiovascular, neurodegenerative, and cancerous diseases necessitates innovative approaches to improve our pathophysiological understanding and ability to modulate biological processes.
Coquart P, El Haddad A, Koutsouras DA, Bolander J.   +3 more
europepmc   +2 more sources

In vitro modelling of extracellular matrix changes during skin aging: from static 2D to 3D dynamic microphysiological systems [PDF]

Microsystems & Nanoengineering
Skin aging results from a combination of intrinsic factors and exogenous stimuli, leading to changes in the structure and components of the extracellular matrix (including the skin basement membrane), which directly influence the aging process.
Yu Yao, Zilin Zhang, Jing Zhang, Yuan Gao, Xiaoran Li, Keyu Yang, Nuo Si, Zaozao Chen, Zhongze Gu, Ningbei Yin   +9 more
doaj   +2 more sources

Revolutionizing Biomedical Research: Unveiling the Power of Microphysiological Systems with Advanced Assays, Integrated Sensor Technologies, and Real-Time Monitoring. [PDF]

ACS Omega
The limitation of animal models to imitate a therapeutic response in humans is a key problem that challenges their use in fundamental research. Organ-on-a-chip (OOC) devices, also called microphysiological systems (MPS), are devices containing a lining ...
Samantasinghar A, Sunildutt N, Ahmed F, Memon FH, Kang C, Choi KH.   +5 more
europepmc   +2 more sources

Application of microphysiological systems to unravel the mechanisms of schistosomiasis egg extravasation. [PDF]

Front Cell Infect Microbiol
Despite decades of control efforts, the prevalence of schistosomiasis remains high in many endemic regions, posing significant challenges to global health. One of the key factors contributing to the persistence of the disease is the complex life cycle of
Alfred MO, Ochola L, Okeyo K, Bae E, Ogongo P, Odongo D, Njaanake K, Robinson JP.   +7 more
europepmc   +2 more sources