Results 11 to 20 of about 24,554,140 (185)

Microphysiological systems for human aging research. [PDF]

Aging Cell
Recent advances in microphysiological systems (MPS), also known as organs‐on‐a‐chip (OoC), enable the recapitulation of more complex organ and tissue functions on a smaller scale in vitro.
Park S, Laskow TC, Chen J, Guha P, Dawn B, Kim DH.   +5 more
europepmc   +4 more sources

Modelling the innate immune system in microphysiological systems.

Lab Chip
This critical review aims to highlight how modeling of the immune response has adapted over time to utilize microphysiological systems. Topics covered here will discuss the integral components of the immune system in various human body systems, and how ...
Rupar MJ, Hanson H, Rogers S, Botlick B, Trimmer S, Hickman JJ.   +5 more
europepmc   +5 more sources

Recommendations on fit-for-purpose criteria to establish quality management for microphysiological systems and for monitoring their reproducibility. [PDF]

Stem Cell Reports
Summary Cell culture technology has evolved, moving from single-cell and monolayer methods to 3D models like reaggregates, spheroids, and organoids, improved with bioengineering like microfabrication and bioprinting.
Pamies D, Ekert J, Zurich MG, Frey O, Werner S, Piergiovanni M, Freedman BS, Keong Teo AK, Erfurth H, Reyes DR, Loskill P, Candarlioglu P, Suter-Dick L, Wang S, Hartung T, Coecke S, Stacey GN, Wagegg BA, Dehne EM, Pistollato F, Leist M.   +20 more
europepmc   +3 more sources

Validation of microphysiological systems for interpreting patient heterogeneity requires robust reproducibility analytics and experimental metadata. [PDF]

Cell Rep Methods
Summary Multi-cell-type, 3D microphysiological systems (MPS) that recapitulate normal organ/organ system functions and the progression of diseases are being applied in drug discovery and development programs to enable precision medicine.
Miedel MT, Varmazyad M, Xia M, Brooks MM, Gavlock DC, Reese C, Behari J, Soto-Gutierrez A, Gough A, Taylor DL, Schurdak ME.   +10 more
europepmc   +2 more sources

Microphysiological systems for solid tumor immunotherapy: opportunities and challenges [PDF]

Microsystems & Nanoengineering, 2023
Immunotherapy remains more effective for hematologic tumors than for solid tumors. One of the main challenges to immunotherapy of solid tumors is the immunosuppressive microenvironment these tumors generate, which limits the cytotoxic capabilities of ...
Sara Abizanda-Campo, María Virumbrales-Muñoz, Mouhita Humayun, Ines Marmol, David J. Beebe, Ignacio Ochoa, Sara Oliván, Jose M. Ayuso   +7 more
doaj   +2 more sources

Highly Strong and Transparent Hydrogel Elastomers Microfabricated for 3D Microphysiological Systems. [PDF]

ACS Appl Mater Interfaces
3D microarchitected hydrogels have recently been exploited to establish microphysiological systems for preclinical studies. However, promising hydrogels, unlike anhydrous elastomers, which have been widely adopted for device microfabrication, are still ...
Li W, Li L, He H, Peng W, Zhou Z, Wu W, Lv D, Chen Y, Pan W, Zhou X, Yin J, Yang M.   +11 more
europepmc   +2 more sources

Engineering of tissue in microphysiological systems demonstrated by modelling skeletal muscle. [PDF]

Regen Biomater
Research on myogenesis and myogenic pathologies has garnered significant attention in recent years. However, traditional in vitro modeling approaches have struggled to fully replicate the complex functions of skeletal muscle. This limitation is primarily
Gao Y, Zhang Z, Yao Y, Zhang J, Li X, Yang K, Si N, Chen Z, Gu Z, Yin N.   +9 more
europepmc   +2 more sources

Microglia-containing neural organoids as brain microphysiological systems for long-term culture. [PDF]

Front Cell Neurosci
Microglia, essential for brain development, homeostasis, and neuroinflammation, originate from the yolk sac during embryogenesis and migrate into the developing brain.
Rittenhouse A, Krall C, Plotkin J, Alam El Din DM, Kincaid B, Laird J, Smirnova L.   +6 more
europepmc   +2 more sources

Strategies to control cellular spatial organization in microphysiological systems [PDF]

Microsystems & Nanoengineering
Spatial organization is fundamental to tissue physiology, as it governs how cells migrate, grow, differentiate, and interact within their native environments.
Hung Dong Truong, Zhixing Ge, Elgene Chng, Y-Van Tran, Yusheng Zhang, Chwee Teck Lim   +5 more
doaj   +2 more sources

Pillar arrays as tunable interfacial barriers for microphysiological systems [PDF]

Communications Engineering
We report on the design and fabrication of a circular pillar array as an interfacial barrier for microfluidic microphysiological systems (MPS). Traditional barrier interfaces, such as porous membranes and microchannel arrays, present limitations due to ...
Ishan Goswami, Yongdeok Kim, Gabriel Neiman, Brian Siemons, Jazmin I. Velazquez, Kerem Yazgan, Tammy Ng, Sudipta Ashe, Kevin E. Healy   +8 more
doaj   +2 more sources