Results 21 to 30 of about 24,554,140 (185)

Complex or not too complex? One size does not fit all in next generation microphysiological systems

iScience
Summary: In the attempt to overcome the increasingly recognized shortcomings of existing in vitro and in vivo models, researchers have started to implement alternative models, including microphysiological systems.
Simone Bersini, Chiara Arrigoni, Giuseppe Talò, Christian Candrian, Matteo Moretti   +4 more
doaj   +2 more sources

AI‐Driven Microphysiological Systems for Advancing Nanoparticle Therapeutics

Advanced Intelligent Systems
Nanoparticles (NPs) play a critical role in applications ranging from medicine to materials science, requiring precise control of properties, such as size, shape, and surface chemistry.
Yedam Lee, Jaehong Min, Sujin Kim, Jihoon Ko   +3 more
doaj   +2 more sources

Multi-Organ Microphysiological Systems Targeting Specific Organs for Recapitulating Disease Phenotypes via Organ Crosstalk. [PDF]

Small Sci
Various systemic metabolic diseases arise from prolonged crosstalk across multiple organs, triggering serious impairments in various physiological systems.
Kim JJ, Bae M, Cho DW.
europepmc   +2 more sources

Engineering human midbrain organoid microphysiological systems to model prenatal PFOS exposure. [PDF]

Sci Total Environ
Perfluorooctane sulfonate (PFOS), a class of synthetic chemicals detected in various environmental compartments, has been associated with dysfunctions of the human central nervous system (CNS).
Tian C, Cai H, Ao Z, Gu L, Li X, Niu VC, Bondesson M, Gu M, Mackie K, Guo F.   +9 more
europepmc   +2 more sources

Gut-liver microphysiological systems revealed potential crosstalk mechanism modulating drug metabolism. [PDF]

PNAS Nexus
The small intestine and liver play important role in determining oral drug's fate. Both organs are also interconnected through enterohepatic circulation, which imply there are crosstalk through circulating factors such as signaling molecules or ...
Kurniawan DA, Leo S, Inamatsu M, Funaoka S, Aihara T, Aiko M, Rei I, Sakura T, Arakawa H, Kato Y, Matsugi T, Esashika K, Shiraki N, Kume S, Shinha K, Kimura H, Nishikawa M, Sakai Y.   +17 more
europepmc   +2 more sources

Microphysiological Systems for Neurodegenerative Diseases in Central Nervous System [PDF]

Micromachines, 2020
Neurodegenerative diseases are among the most severe problems in aging societies. Various conventional experimental models, including 2D and animal models, have been used to investigate the pathogenesis of (and therapeutic mechanisms for ...
Mihyeon Bae, Hee-Gyeong Yi, Jinah Jang, Dong-Woo Cho   +3 more
doaj   +4 more sources

Microphysiological systems [PDF]

APL Bioengineering, 2019
James J. Hickman, Dongeun Huh, Roger D. Kamm   +2 more
doaj   +3 more sources

Vascular microphysiological systems

Current Opinion in Hematology
Purpose of review This review summarizes innovations in vascular microphysiological systems (MPS) and discusses the themes that have emerged from recent works.
S. Shelton
semanticscholar   +3 more sources

Microphysiological systems to advance human pathophysiology and translational medicine.

J Appl Physiol (1985)
Microphysiological systems (MPS) or "organ-on-a-chip" models are sophisticated tools that harness techniques from cell biology, tissue engineering, and microengineering to recapitulate human physiology.
Harriot AD, Ward CW, Kim DH.
europepmc   +2 more sources

Modeling immunity in microphysiological systems. [PDF]

Exp Biol Med (Maywood), 2023
There is a need for better predictive models of the human immune system to evaluate safety and efficacy of immunomodulatory drugs and biologics for successful product development and regulatory approvals. Current in vitro models, which are often tested in two-dimensional (2D) tissue culture polystyrene, and preclinical animal models fail to fully ...
Kwee BJ, Li X, Nguyen XX, Campagna C, Lam J, Sung KE.   +5 more
europepmc   +3 more sources