Results 31 to 40 of about 24,554,140 (185)

Potential value of animal microphysiological systems.

ALTEX
Microphysiological systems (MPS) are designed to recapitulate aspects of tissue/organ physiology in vivo, thereby providing potential value in safety and efficacy assessments of FDA-regulated products and regulatory decision-making. While there have been
Paul C Brown, B. H. Hooberman, Brianna Skinner, Claudia Wrzesinski, Dayton M. Petibone, Kevin A Ford, Kristi Muldoon-Jacobs, Kyung E Sung, Luis G. Valerio, Nakissa Sadrieh, Paul C. Howard, Peter L Goering, Shelby A. Skoog, Suzanne C. Fitzpatrick, Tracy Chen, Tracy C MacGill, Donna L Mendrick   +16 more
semanticscholar   +3 more sources

Endothelial‐mesenchymal transition in skeletal muscle: Opportunities and challenges from 3D microphysiological systems [PDF]

Bioengineering & Translational Medicine
Fibrosis is a pathological condition that in the muscular context is linked to primary diseases such as dystrophies, laminopathies, neuromuscular disorders, and volumetric muscle loss following traumas, accidents, and surgeries.
Riccardo Francescato, Matteo Moretti, Simone Bersini   +2 more
doaj   +2 more sources

Training the Next Generation of Researchers in the Organ-on-Chip Field

Education Sciences, 2023
Organ-on-chip (OoC) technology bridges the principles of biology and engineering to create a new generation of in vitro models and involves highly interdisciplinary collaboration across STEM disciplines.
Alessia Moruzzi, Tanvi Shroff, Silke Keller, Peter Loskill, Madalena Cipriano   +4 more
doaj   +1 more source

Gastrointestinal microphysiological systems [PDF]

Experimental Biology and Medicine, 2017
Gastrointestinal diseases are a significant health care and economic burden. Prevention and treatment of these diseases have been limited by the available human biologic models. Microphysiological systems comprise organ-specific human cultures that recapitulate many structural, biological, and functional properties of the organ in smaller scale ...
Sarah E, Blutt, James R, Broughman, Winnie, Zou, Xi-Lei, Zeng, Umesh C, Karandikar, Julie, In, Nicholas C, Zachos, Olga, Kovbasnjuk, Mark, Donowitz, Mary K, Estes   +9 more
openaire   +2 more sources

Microphysiological Systems: A Pathologist’s Perspective [PDF]

Veterinary Pathology, 2020
High-throughput in vitro models lack human-relevant complexity, which undermines their ability to accurately mimic in vivo biologic and pathologic responses. The emergence of microphysiological systems (MPS) presents an opportunity to revolutionize in vitro modeling for both basic biomedical research and applied drug discovery.
Radhakrishna Sura, Terry Van Vleet, Brian R. Berridge   +2 more
openaire   +2 more sources

Facile photopatterning of perfusable microchannels in hydrogels for microphysiological systems. [PDF]

Nat Protoc
Mora-Boza A, Mulero-Russe A, Di Caprio N, Burdick JA, O'Neill E, Singh A, García AJ.   +6 more
europepmc   +2 more sources

Vascular microphysiological systems to model diseases [PDF]

Cell and Gene Therapy Insights, 2020
Human vascular microphysiological systems (MPS) represent promising three-dimensional in vitro models of normal and diseased vascular tissue. These systems build upon advances in tissue engineering, microfluidics, and stem cell differentiation and replicate key functional units of organs and tissues.
Qiao, Zhang, Xu, Zhang, George A, Truskey   +2 more
openaire   +2 more sources

Autologous Human Immunocompetent White Adipose Tissue‐on‐Chip

Advanced Science, 2022
Obesity and associated diseases, such as diabetes, have reached epidemic proportions globally. In this era of “diabesity”, white adipose tissue (WAT) has become a target of high interest for therapeutic strategies.
Julia Rogal, Julia Roosz, Claudia Teufel, Madalena Cipriano, Raylin Xu, Wiebke Eisler, Martin Weiss, Katja Schenke‐Layland, Peter Loskill   +8 more
doaj   +1 more source

Animal Model Alternatives in Filovirus and Bornavirus Research

Viruses, 2023
The order Mononegavirales contains a variety of highly pathogenic viruses that may infect humans, including the families Filoviridae, Bornaviridae, Paramyxoviridae, and Rhabodoviridae.
Lina Widerspick, Johanna Friederike Steffen, Dennis Tappe, César Muñoz-Fontela   +3 more
doaj   +1 more source

Stem cell-based vascularization of microphysiological systems [PDF]

Stem Cell Reports, 2021
Microphysiological systems (MPSs) (i.e., tissue or organ chips) exploit microfluidics and 3D cell culture to mimic tissue and organ-level physiology. The advent of human induced pluripotent stem cell (hiPSC) technology has accelerated the use of MPSs to study human disease in a range of organ systems. However, in the reduction of system complexity, the
Browne, Shane, Gill, Elisabeth L, Schultheiss, Paula, Goswami, Ishan, Healy, Kevin E   +4 more
openaire   +4 more sources