Results 41 to 50 of about 24,554,140 (185)

3D organ-on-a-chip: The convergence of microphysiological systems and organoids

Frontiers in Cell and Developmental Biology, 2022
Medicine today faces the combined challenge of an increasing number of untreatable diseases and fewer drugs reaching the clinic. While pharmaceutical companies have increased the number of drugs in early development and entering phase I of clinical ...
Leandra S. Baptista, Leandra S. Baptista, Constance Porrini, Gabriela S. Kronemberger, Gabriela S. Kronemberger, Daniel J. Kelly, Daniel J. Kelly, Daniel J. Kelly, Daniel J. Kelly, Cecile M. Perrault   +9 more
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Microphysiological Systems to Assess Nonclinical Toxicity [PDF]

Current Protocols in Toxicology, 2017
AbstractThe liver and the kidney are key toxicity target organs during drug development campaigns, as they typically carry the burden of drug transport and metabolism. Primary hepatocytes and proximal tubule epithelial cells grown in traditional in vitro 2‐D culture systems do not maintain transporter and metabolic functions, thus limiting their ...
Kirk P, Van Ness, Shih-Yu, Chang, Elijah J, Weber, Danielle, Zumpano, David L, Eaton, Edward J, Kelly   +5 more
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Real-time monitoring of liver fibrosis through embedded sensors in a microphysiological system

Nano Convergence, 2021
Hepatic fibrosis is a foreshadowing of future adverse events like liver cirrhosis, liver failure, and cancer. Hepatic stellate cell activation is the main event of liver fibrosis, which results in excessive extracellular matrix deposition and hepatic ...
Hafiz Muhammad Umer Farooqi, Bohye Kang, Muhammad Asad Ullah Khalid, Abdul Rahim Chethikkattuveli Salih, Kinam Hyun, Sung Hyuk Park, Dongeun Huh, Kyung Hyun Choi   +7 more
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Rapid Prototyping of Multilayer Microphysiological Systems

ACS Biomaterials Science & Engineering, 2020
Microfluidic organs-on-chips aim to realize more biorelevant in vitro experiments compared to traditional two-dimensional (2D) static cell culture. Often such devices are fabricated via poly(dimethylsiloxane) (PDMS) soft lithography, which offers benefits (e.g., high feature resolution) along with drawbacks (e.g., prototyping time/costs).
Sanjin Hosic, Adam J. Bindas, Marissa L. Puzan, Will Lake, Jonathan R. Soucy, Fanny Zhou, Ryan A. Koppes, David T. Breault, Shashi K. Murthy, Abigail N. Koppes   +9 more
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Omics of endothelial cell dysfunction in sepsis

Vascular Biology, 2022
During sepsis, defined as life-threatening organ dysfunction due to dysregulated host response to infection, systemic inflammation activates endothelial cells and initiates a multifaceted cascade of pro-inflammatory signaling events, resulting in ...
Jordan C Langston, Michael T Rossi, Qingliang Yang, William Ohley, Edwin Perez, Laurie E Kilpatrick, Balabhaskar Prabhakarpandian, Mohammad F Kiani   +7 more
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Human Microphysiological Systems and Organoids as in Vitro Models for Toxicological Studies

Frontiers in Public Health, 2018
Organoids and microphysiological systems represent two current approaches to reproduce organ function in vitro. These systems can potentially provide unbiased assays of function which are needed to understand the mechanism of action of environmental ...
George A. Truskey
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Microphysiological system design: simplicity is elegance

Current Opinion in Biomedical Engineering, 2020
Design parameters for microphysiological systems (MPS) are driven by the need for new tools to answer questions focusing on human physiology in a robust and reliable manner. Within this perspective, engineering benchmarks and principles are identified to guide the construction of new devices in the MPS field, with emphasis placed on the design ...
Samuel S. Hinman, Raehyun Kim, Yuli Wang, K. Scott Phillips, Peter J. Attayek, Nancy L. Allbritton   +5 more
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Microphysiologic systems in female reproductive biology [PDF]

Experimental Biology and Medicine, 2017
Microphysiologic systems (MPS), including new organ-on-a-chip technologies, recapitulate tissue microenvironments by employing specially designed tissue or cell culturing techniques and microfluidic flow. Such systems are designed to incorporate physiologic factors that conventional 2D or even 3D systems cannot, such as the multicellular dynamics of a
Alexandria N, Young, Georgette, Moyle-Heyrman, J Julie, Kim, Joanna E, Burdette   +3 more
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Microphysiological systems modeling acute respiratory distress syndrome that capture mechanical force-induced injury-inflammation-repair

APL Bioengineering, 2019
Complex in vitro models of the tissue microenvironment, termed microphysiological systems, have enormous potential to transform the process of discovering drugs and disease mechanisms.
Hannah Viola, Jonathan Chang, Jocelyn R. Grunwell, Louise Hecker, Rabindra Tirouvanziam, James B. Grotberg, Shuichi Takayama   +6 more
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Modular Microphysiological System for Modeling of Biologic Barrier Function

Frontiers in Bioengineering and Biotechnology, 2020
Microphysiological systems, also known as organs-on-chips, are microfluidic devices designed to model human physiology in vitro. Polydimethylsiloxane (PDMS) is the most widely used material for organs-on-chips due to established microfabrication methods,
Matthew Ishahak, Jordan Hill, Quratulain Amin, Laura Wubker, Adiel Hernandez, Alla Mitrofanova, Alexis Sloan, Alessia Fornoni, Alessia Fornoni, Ashutosh Agarwal, Ashutosh Agarwal   +10 more
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