Results 51 to 60 of about 24,554,140 (185)

3D printed scaffolds: Challenges toward developing relevant cellular in vitro models

Biomaterials and Biosystems, 2022
Three-dimensional (3D) cell culture technology has rapidly emerged, as a result of the increasing demand for improved in vitro systems that better resemble human physiology.
Beatriz Molina-Martínez, Luis M. Liz-Marzán   +1 more
doaj   +1 more source

Matrigel 3D bioprinting of contractile human skeletal muscle models recapitulating exercise and pharmacological responses

Communications Biology, 2021
Alave-Furrer et al adapted their recently-developed 3D bioprinting platform to allow microvalve-based drop-on-demand printing of cell-laden Matrigel containing primary human muscle precursor cells.
Angela Alave Reyes-Furrer, Sonia De Andrade, Dominic Bachmann, Heidi Jeker, Martin Steinmann, Nathalie Accart, Andrew Dunbar, Martin Rausch, Epifania Bono, Markus Rimann, Hansjoerg Keller   +10 more
doaj   +1 more source

Microphysiological Systems: Design, Fabrication, and Applications

ACS Biomaterials Science & Engineering, 2020
Microphysiological systems, including organoids, 3-D printed tissue constructs and organ-on-a-chips (organ chips), are physiologically relevant in vitro models and have experienced explosive growth in the past decades. Different from conventional, tissue culture plastic-based in vitro models or animal models, microphysiological systems recapitulate key
Kai Wang, Kun Man, Jiafeng Liu, Yang Liu, Qi Chen, Yong Zhou, Yong Yang   +6 more
openaire   +3 more sources

Mera: A scalable high throughput automated micro-physiological system

SLAS Technology, 2023
There is an urgent need for scalable Microphysiological Systems (MPS's)11 Microphysiological systems (MPSs), Microtissue (MT), Polyetheretherketone (PEEK), Polytetrafluoroethylene (PTFE), Polystyrene (PS) that can better predict drug efficacy and ...
Finola E. Cliffe, Conor Madden, Patrick Costello, Shane Devitt, Sumir Ramesh Mukkunda, Bhairavi Bengaluru Keshava, Howard O. Fearnhead, Aiste Vitkauskaite, Mahshid H. Dehkordi, Walter Chingwaru, Milosz Przyjalgowski, Natalia Rebrova, Mark Lyons   +12 more
doaj   +1 more source

Modeling early stage atherosclerosis in a primary human vascular microphysiological system

Nature Communications, 2020
Human microphysiological systems (MPS) have some advantages over animal models to study the mechanisms of disease. Here the authors use a tissue-engineered blood vessel MPS to create a model of early stage atherosclerosis and assess the effect of several
Xu Zhang, Muath Bishawi, Ge Zhang, Varun Prasad, Ellen Salmon, Jason J. Breithaupt, Qiao Zhang, George A. Truskey   +7 more
doaj   +1 more source

Split Ends Inhibits the Dedifferentiation of imINP to Prevent the Generation of Supernumerary Type II Neuroblasts in Drosophila

Cells
Investigating the mechanisms that maintain different types of neural stem cells is essential for brain development. While factors maintaining distinct Drosophila melanogaster neuroblasts (NBs) have been identified, additional factors remain unidentified.
Qingxia Zhou, Fuhao Zhang, Sifan Gong, Shuliu Zhang, Wenting Gong, Menglong Rui, Su Wang   +6 more
doaj   +1 more source

Engineering and monitoring cellular barrier models

Journal of Biological Engineering, 2018
Epithelia and endothelia delineate tissue compartments and control their environments by regulating the passage of ions and solutes. This barrier function is essential for the development and maintenance of multicellular organisms, and its dysfunction is
Jose Yeste, Xavi Illa, Mar Alvarez, Rosa Villa   +3 more
doaj   +1 more source

A Microphysiological System for Studying Nonalcoholic Steatohepatitis [PDF]

Hepatology Communications, 2019
Nonalcoholic steatohepatitis (NASH) is the most severe form of nonalcoholic fatty liver disease (NAFLD), which to date has no approved drug treatments. There is an urgent need for better understanding of the genetic and molecular pathways that underlie NAFLD/NASH, and currently available preclinical models, be they
Kostrzewski, T, Maraver, P, Ouro-Gnao, L, Levi, A, Snow, S, Miedzik, A, Rombouts, K, Hughes, D   +7 more
openaire   +4 more sources

Reproducibility and Robustness of a Liver Microphysiological System PhysioMimix LC12 under Varying Culture Conditions and Cell Type Combinations

Bioengineering, 2023
The liver is one of the key organs for exogenous and endogenous metabolism and is often a target for drug- and chemical-driven toxicity. A wide range of experimental approaches has been established to model and characterize the mechanisms of drug- and ...
Alicia Y. Lim, Yuki Kato, Courtney Sakolish, Alan Valdiviezo, Gang Han, Piyush Bajaj, Jason Stanko, Stephen S. Ferguson, Remi Villenave, Philip Hewitt, Rhiannon N. Hardwick, Ivan Rusyn   +11 more
doaj   +1 more source

Patient-Derived Microphysiological Systems for Precision Medicine. [PDF]

Adv Healthc Mater, 2023
AbstractPatient‐derived microphysiological systems (P‐MPS) have emerged as powerful tools in precision medicine that provide valuable insight into individual patient characteristics. This review discusses the development of P‐MPS as an integration of patient‐derived samples, including patient‐derived cells, organoids, and induced pluripotent stem cells,
Ko J, Song J, Choi N, Kim HN.
europepmc   +3 more sources