Results 101 to 110 of about 21,599 (235)

Adipose-derived mesenchymal stem cells from patients with atherosclerotic renovascular disease have increased DNA damage and reduced angiogenesis that can be modified by hypoxia [PDF]

, 2016
Representative flow cytometric plots (FACS) showing that AMSCs expressed HLA-ABC, CD44, CD90, CD29, CD73, and CD105 markers, and did not express HLA-DR, CD45, CD14 or CD34 markers.
Ahmed Saad, Allan B. Dietz, Andre J. van Wijnen, Hui Tang, LaTonya Hickson, Lilach Lerman, Sandra Herrmann, Stephen Textor, Xiang-Yang Zhu   +8 more
core   +3 more sources

Targeting Microbiome Metabolites: Reshaping Immunotherapy and Clinical Management Strategies for Colorectal Cancer

iMetaMed, EarlyView.
The occurrence and progression of colorectal cancer are intricately linked to metabolites produced by the gut microbiota. Metabolites generated by pathogenic microbial communities can promote colorectal cancer development by reshaping the immune microenvironment.
Xinrui Yang, Ke Zhang, Lijie Xia, Jinyao Li   +3 more
wiley   +1 more source

Extracellular vesicle expansion of PMIS‐miR‐210 expression inhibits colorectal tumour growth via apoptosis and an XIST/NME1 regulatory mechanism

Clinical and Translational Medicine, 2022
Background Colorectal cancer (CRC) has a high mortality rate, and therapeutic approaches to treat these cancers are varied and depend on the metabolic state of the tumour.
Steven Eliason, Liu Hong, Yan Sweat, Camille Chalkley, Huojun Cao, Qi Liu, Hank Qi, Hongwei Xu, Fenghuang Zhan, Brad A. Amendt   +9 more
doaj   +1 more source

Metabolic Signatures and Diagnostic Prediction Models for Coronary Artery Disease and Type 2 Diabetes Mellitus: Insights From an Exploratory Study

iNew Medicine, EarlyView.
Metabolomic & lipidomic analysis reveals metabolic overlap between CAD & T2DM, highlighting 7 key metabolites as potential biomarkers. A predictive model based on these achieves high accuracy, potentially advancing precision medicine & metabolic insights.
Zhihua Wang, Meiming Su, Ying Li, Yapei Li, Shuo Chen, Ting Peng, Hans Strijdom, Jiangang Wang, Jianping Weng, Suowen Xu   +9 more
wiley   +1 more source

Effect of local administration of microRNA-31/210 on bone regeneration surrounding hydroxyapatite/tricalcium phosphate -coated titanium implant in an ovariectomized rat model

Regenerative Therapy
Background: With the aging population, the prevalence of total joint arthroplasty in older adults with compromised bone conditions, such as osteoporosis, is increasing, raising concerns on the initial fixation of implants and aseptic loosening.
Shinichi Ueki, Takeshi Shoji, Hideki Saka, Hiroki Kaneta, Hiroyuki Morita, Yosuke Kozuma, Nobuo Adachi   +6 more
doaj   +1 more source

Efficacy of omega‐3 fatty acids as a functional food: a multifaceted approach to health reinforcement

Journal of the Science of Food and Agriculture, EarlyView.
Abstract Omega‐3 fatty acids (omega‐3s) are polyunsaturated fatty acids linked with numerous health benefits. Omega‐3s exhibit multifaceted activities through various mechanisms. Eicosapentaenoic acid (EPA) alleviates oxidative stress by lowering reactive oxygen species and improving oxidative stress in brain tissues and acts against neurodegenerative ...
Md Faruque Ahmad, Abdulrahman A Alsayegh, Anjum Khanam, Awais Ahmed, António Raposo, Farkad Bantun, Md Zeyaullah, Ahmad O Babalghith, Abdullah F Aldairi, Boshra Mozaffar, Mohammed F Bajahzer, Mohamed H Abdelrahman, Mohammad Intakhab Alam   +12 more
wiley   +1 more source

Inhibition of microRNA-210 provides neuroprotection in hypoxic–ischemic brain injury in neonatal rats

Neurobiology of Disease, 2016
Perinatal hypoxic–ischemic encephalopathy (HIE) is associated with high neonatal mortality and severe long-term neurologic morbidity. Yet the mechanisms of brain injury in infants with HIE remain largely elusive.
Qingyi Ma, Chiranjib Dasgupta, Yong Li, Nikita M. Bajwa, Fuxia Xiong, Benjamin Harding, Richard Hartman, Lubo Zhang   +7 more
doaj   +1 more source

MicroRNAs mediate metabolic stresses and angiogenesis [PDF]

, 2011
MicroRNAs are short endogenous RNA molecules that are able to regulate (mainly inhibiting) gene expression at the post-transcriptional level. The MicroRNA expression profile is cell-specific, but it is sensitive to perturbations produced by stresses and ...
Patella, Francesca, Rainaldi, Giuseppe
core   +1 more source

The Role of MicroRNA-210 in Esophageal Squamous Cell Carcinoma

YAKUGAKU ZASSHI, 2012
In this review, we summarize our findings on microRNA-210 (miR-210) and the target gene, and discuss their significance in human esophageal squamous cell carcinoma (ESCC). MicroRNAs are evolutionarily conserved small noncoding RNAs (20-23 nucleotides) that bind to complementary sequences in the 3' UTR of target mRNAs and regulate gene expression by the
openaire   +3 more sources

MiR‐145‐5p Attenuates Doxorubicin‐Induced Heart Injury Through Targeting Cardiomyocyte Pyroptosis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Doxorubicin (DOX), a potent anthracycline chemotherapeutic, exhibits dose‐dependent cardiotoxicity that limits its clinical utility. Although miR‐145‐5p demonstrates cardioprotective properties in cardiovascular diseases, its role in DOX‐induced cardiomyopathy remains undefined.
Xing‐Tao Chen, Yong‐Hong Yu, Yan‐Hua Du, Lin Xu, Xiang‐Ping Meng   +4 more
wiley   +1 more source