Results 91 to 100 of about 22,552 (272)

Exploring the Potential of Zero‐Dimensional Carbon Nanomaterials in Photoluminescent, Electrochemiluminescent and Electrochemical Sensors

Advanced Materials Interfaces, EarlyView.
Zero‐dimensional carbon nanomaterials are presented as multifunctional platforms linking structure, property, and sensing performance. Surface engineering and heteroatom doping modulate electron‐transfer and luminescent behavior, enabling electrochemical, photoluminescent, and electrochemiluminescent detection. Fundamental design principles, analytical
Gustavo Martins, Jeferson Luiz Gogola, Ava Gevaerd, Cristiane Kalinke, Paulo Roberto de Oliveira, Fabio Roberto Caetano, Bruno Campos Janegitz, Márcio Fernando Bergamini, Luiz Humberto Marcolino‐Junior   +8 more
wiley   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Hypoxia-regulated MicroRNA-210 in neuronal plasticity [PDF]

, 2018
In recent years increasing evidence has established microRNAs as critical regulators of neuronal development and plasticity that can act locally, in an activity-dependent manner. The hypoxia-regulated microRNA-210 (miR-210) is a highly conserved miRNA, widely studied for its role in regulating cellular response to low oxygen conditions. Previously, our
openaire   +3 more sources

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

Advanced Science, EarlyView.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu, Mengtao Sun, Lusheng Li, Jieqiong Wang, Shibiao Wan   +4 more
wiley   +1 more source

Synovial Fluid MicroRNA-210 as a Potential Biomarker for Early Prediction of Osteoarthritis. [PDF]

Biomed Res Int, 2019
Early detection and treatment are critical in the management of osteoarthritis (OA). OA is closely associated with angiogenesis and the inhibition of angiogenesis presents a novel therapeutic approach to reduce inflammation and pain in OA. Recent reports suggest that circulating microRNAs (miRNAs) have great potential as biomarkers for the diagnosis ...
Xie W, Su W, Xia H, Wang Z, Su C, Su B.
europepmc   +3 more sources

MicroRNA-210 as a novel blood biomarker in acute cerebral ischemia

Frontiers in Bioscience, 2011
MicroRNA-210 (miR-210), a master and pleiotropic hypoxia-microRNA, plays multiple roles in brain ischemia. However, miR-210 expression and its function in humans have not been explored. The aim of our study is to evaluate the correlation of blood miR-210 with clinical findings in acute ischemic stroke.
Lili, Zeng, Jianrong, Liu, Yongting, Wang, Ling, Wang, Suiqing, Weng, Yaohui, Tang, Chaobo, Zheng, Qi, Cheng, Shengdi, Chen, Guo-Yuan, Yang   +9 more
openaire   +2 more sources

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

An Aγ-globin G->A gene polymorphism associated with β(0)39 thalassemia globin gene and high fetal hemoglobin production [PDF]

, 2017
Increase of the expression of γ-globin gene and high production of fetal hemoglobin (HbF) in β-thalassemia patients is widely accepted as associated with a milder or even asymptomatic disease. The search for HbF-associated polymorphisms (such as the XmnI,
Bianchi, Nicoletta, Borgatti, Monica, Breveglieri, Giulia, Chiavilli, Francesco, Cosenza, Lucia Carmela, Finotti, Alessia, Gambari, Roberto, Gamberini, MARIA RITA, Lampronti, Ilaria, Montagner, Giulia, Zuccato, Cristina   +10 more
core   +1 more source

Acute hypoxia induces upregulation of microRNA-210 expression in glioblastoma spheroids [PDF]

CNS Oncology, 2015
Tumor hypoxia and presence of tumor stem cells are related to therapeutic resistance and tumorigenicity in glioblastomas. The aim of the present study was therefore to identify microRNAs deregulated in acute hypoxia and to identify possible associated changes in stem cell markers.Glioblastoma spheroid cultures were grown in either 2 or 21% oxygen ...
Rosenberg, Tine Agerbo, Thomassen, Mads, Jensen, Stine Skov, Larsen, Martin Jakob, Sørensen, Kristina Pilekær, Hermansen, Simon Kjær, Kruse, Torben A, Kristensen, Bjarne Winther   +7 more
openaire   +3 more sources

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source