Results 71 to 80 of about 21,064 (212)

The Role of MicroRNA-210 in Esophageal Squamous Cell Carcinoma

YAKUGAKU ZASSHI, 2012
In this review, we summarize our findings on microRNA-210 (miR-210) and the target gene, and discuss their significance in human esophageal squamous cell carcinoma (ESCC). MicroRNAs are evolutionarily conserved small noncoding RNAs (20-23 nucleotides) that bind to complementary sequences in the 3' UTR of target mRNAs and regulate gene expression by the
openaire   +3 more sources

MicroRNA-210 Enhances Fibrous Cap Stability in Advanced Atherosclerotic Lesions [PDF]

Circulation Research, 2017
Rationale: In the search for markers and modulators of vascular disease, microRNAs (miRNAs) have emerged as potent therapeutic targets. Objective: To investigate miRNAs of clinical interest in patients with unstable carotid ...
Eken, Suzanne M., Jin, Hong, Chernogubova, Ekaterina, Li, Yuhuang, Simon, Nancy, Sun, Changyan, Korzunowicz, Greg, Busch, Albert, Bäcklund, Alexandra, Österholm, Cecilia, Razuvaev, Anton, Renné, Thomas, Eckstein, Hans Henning, Pelisek, Jaroslav, Eriksson, Per, González Díez, María, Perisic Matic, Ljubica, Schellinger, Isabel N., Raaz, Uwe, Leeper, Nicholas J., Hansson, Göran K., Paulsson-Berne, Gabrielle, Hedin, Ulf, Maegdefessel, Lars   +23 more
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Hydrogel‐based drug delivery systems for intracerebral hemorrhage with therapeutic advances and emerging roles of the bone–brain axis

Interdisciplinary Medicine, EarlyView.
Hydrogel‐based drug delivery systems offer a promising approach for treating intracerebral hemorrhage (ICH) by overcoming blood‐brain barrier limitations, enabling precise, sustained release of neuroprotective and anti‐inflammatory agents. These systems enhance treatment efficacy, but challenges remain in biosafety, drug penetration, and scalability ...
Haojun Shi, Min Chen, Yisheng Chen, MengYao Li, Jiale Ma, Zuozhen Yin, Li Wu, YangBao Miao, Zemin Ou, Ke Wu, Zhijie Xu, Lizhi Li, Shaocong Zhao, Shiwei He, Bin Huang, Guanwen He, Guanghui Wu, John H. Zhang, Liang Shi   +18 more
wiley   +1 more source

miR-210 Protects Renal Cell Against Hypoxia-induced Apoptosis by Targeting HIF-1 Alpha

Molecular Medicine, 2017
The kidney is vulnerable to hypoxia-induced injury. One of the mechanisms underlying this phenomenon is cell apoptosis triggered by hypoxia-inducible factor-1- α (HIF-1α) activation.
Li-Li Liu, Dahu Li, Yun-Ling He, Yan-Zhao Zhou, Sheng-Hui Gong, Li-Ying Wu, Yong-Qi Zhao, Xin Huang, Tong Zhao, Lun Xu, Kui-Wu Wu, Ming-Gao Li, Ling-Ling Zhu, Ming Fan   +13 more
doaj   +1 more source

MicroRNA-210 negatively regulates the radiosensitivity of nasopharyngeal carcinoma cells

Molecular Medicine Reports, 2017
Radiotherapy is one of the primary methods of treatment of malignant tumors, however, resistance to radiation is a major problem. The reasons for the radioresistance are still poorly understood. However, it is generally accepted that microRNAs (miRNAs or miRs) can regulate the radiosensitivity of tumors.
Bo-Yi, Li, Yi, Luo, Wen-Si, Zhao, Lu, Zhang, Han-Jing, Zhou, Yu-Chun, Zou, Tao, Zhang   +6 more
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Unveiling the roles of extracellular vesicles in hematologic malignancies: Pathogenesis, diagnostic tools, and clinical translation

Interdisciplinary Medicine, EarlyView.
Extracellular vesicles play pivotal roles in both healthy hematopoiesis and hematologic malignancies. They not only regulate hematopoietic stem cell fitness but also drive cancer progression and drug resistance. Their clinical potential spans from serving as non‐invasive biomarkers to acting as innovative therapeutic platforms and drug delivery ...
Fengyu Chen, Zhiyuan Wu, Feng Zhang, Yuan Meng, Hongyan Liao, Tony Y. Hu   +5 more
wiley   +1 more source

miR-210 is essential to retinal homeostasis in fruit flies and mice

Biology Direct
Background miR-210 is one of the most evolutionarily conserved microRNAs. It is known to be involved in several physiological and pathological processes, including response to hypoxia, angiogenesis, cardiovascular diseases and cancer. Recently, new roles
Davide Colaianni, Federico Virga, Annamaria Tisi, Chiara Stefanelli, Germana Zaccagnini, Paola Cusumano, Gabriele Sales, Mihai Bogdan Preda, Fabio Martelli, Daniela Taverna, Massimiliano Mazzone, Cristiano Bertolucci, Rita Maccarone, Cristiano De Pittà   +13 more
doaj   +1 more source

Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit [PDF]

Journal of the American Chemical Society, 2017
A hypoxic state is critical to the metastatic and invasive characteristics of cancer. Numerous pathways play critical roles in cancer maintenance, many of which include noncoding RNAs such as microRNA (miR)-210 that regulates hypoxia inducible factors (HIFs). Herein, we describe the identification of a small molecule named Targapremir-210 that binds to
Matthew G. Costales, Christopher L. Haga, Sai Pradeep Velagapudi, Jessica L. Childs-Disney, Donald G. Phinney, Matthew D. Disney   +5 more
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Flavonoids in Nasal Therapeutics: Biological Activities, Delivery Challenges, and Formulation Strategies–A Systematic Review

Phytotherapy Research, EarlyView.
Overview of the therapeutic potential of flavonoids in nasal delivery systems, highlighting their benefits to the human nasal cavity, and applications in the treatment of respiratory and brain‐related diseases. ABSTRACT Flavonoids represent a significant group of secondary metabolites.
Jeniffer Viviana Ramirez Hernández, Sara Elis Bianchi, Flávia Nathiely Silveira Fachel, Elizandra Braganhol, Sheila Porto de Matos, Valquíria Linck Bassani   +5 more
wiley   +1 more source

Prognostic evaluation of microRNA-210 in various carcinomas

Medicine, 2017
We performed this meta-analysis to provide a comprehensive evaluation of the role of MicroRNA-210 (miR-210) expression on the overall survival (OS) rate of cancers.We searched for relevant available literatures on miR-210 and cancer until November 1st, 2016 on the databases PubMed, EMBASE, Cochrane Library, and Science Direct database.
Liu, Yincheng, Wang, Yichun, Xu, Qitong, Zhou, Xiang, Qin, Zhiqiang, Chen, Chen, Zhang, Qijie, Tian, Ye, Zhang, Chao, Li, Xiao, Qin, Chao   +10 more
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