Results 101 to 110 of about 21,064 (212)

Understanding exosomes in regenerative dentistry

Periodontology 2000, EarlyView.
Abstract Background Regenerative dentistry is shifting from cell‐based strategies to cell‐free biologics capable of orchestrating intricate tissue repair. Exosomes, nanosized extracellular vesicles carrying bioactive molecular payloads, have emerged as central modulators of intercellular communication.
Paras Ahmad, Anton Sculean, Richard J. Miron   +2 more
wiley   +1 more source

Understanding exosomes in diabetic wound healing

Periodontology 2000, EarlyView.
Abstract Background Diabetic wounds signify a major complication of diabetes mellitus, characterized by chronic inflammation, compromised angiogenesis, and high risk of infection, amputation, and mortality. Contemporary therapies remain limited in efficacy and durability.
Paras Ahmad, Yulan Wang, Yufeng Zhang, Anton Sculean, Richard J. Miron   +4 more
wiley   +1 more source

HIF-1α had Pivotal Effects on Downregulation of miR-210 Decreasing Viability and Inducing Apoptosis in Hypoxic Chondrocytes

The Scientific World Journal, 2014
Hypoxia-inducible factor 1-alpha (HIF-1α) and some microRNA (miRNAs) play pivotal roles in response to hypoxia-related physiologic and pathophysiologic responses.
Zhiqiang Chang, Lifeng Huo, Yimin Wu, Pei Zhang   +3 more
doaj   +1 more source

Meta-analysis of human lung cancer microRNA expression profiling studies comparing cancer tissues with normal tissues

Journal of Experimental & Clinical Cancer Research, 2012
Background Lung cancer is the major cause of cancer death globally, it is often diagnosed at an advanced stage and has one of the lowest survival rates of any type of cancer.
Guan Peng, Yin Zhihua, Li Xuelian, Wu Wei, Zhou Baosen   +4 more
doaj   +1 more source

Independent and synergistic effects of maternal and paternal obesogenic diets on offspring early‐life outcomes in the rat

Experimental Physiology, EarlyView.
Abstract Independent effects of maternal obesogenic diets on offspring outcomes are acknowledged, but data on paternal and combined maternal–paternal obesity remain limited. We investigated independent and combined maternal–paternal effects of an obesogenic (OB) high‐fat, high‐sugar diet on offspring outcomes.
Khurram Jahangir Toor, Mehwish Abbasi, Swetha Muralidharan, Elisa Weiss, Elwyn C. Firth, Anna P. Ponnampalam, David S. Musson, Mark H. Vickers, Benjamin B. Albert   +8 more
wiley   +1 more source

In silico predictions of action potential propagation in doxorubicin cardiotoxicity: A parametric study using preclinical 3D magnetic resonance imaging‐based fibrotic left ventricle models

The Journal of Physiology, EarlyView.
Abstract figure legend Schematic overview of the study's methodology and key findings. In a preclinical swine model, doxorubicin administration induced cardiotoxicity, characterized by diffuse fibrotic remodelling and altered electrical function, as assessed by magnetic resonance (MR) imaging and electrophysiological mapping.
Javier Villar‐Valero, Jairo Rodríguez Padilla, Nicolas Cedilnik, Buntheng Ly, Juan F. Gomez, Maxime Sermesant, Mihaela Pop, Beatriz Trenor   +7 more
wiley   +1 more source

Implantation outcome is Associated with Mucin-16, MiR- 1226 and MiR-210 Expression during IVF of Iraqi Females

Iraqi Journal of Pharmaceutical Sciences
One of the main obstacles to early pregnancy and assisted reproduction is embryo implantation failure. Endometrial receptivity and the interactions between the embryo and the mother determine implantation.
Israa M.Majeed, Asmaa M. Salih Almohaidi
doaj   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

Clinical Significance of miR-210 and its Prospective Signaling Pathways in Non-Small Cell Lung Cancer: Evidence from Gene Expression Omnibus and the Cancer Genome Atlas Data Mining with 2763 Samples and Validation via Real-Time Quantitative PCR

Cellular Physiology and Biochemistry, 2018
Background/Aims: Since the function of microRNA (miR)-210 in non-small cell lung cancer (NSCLC) remains unclear, we aimed to explore the clinical significance of miR-210 in NSCLC.
Rong-quan He, Wei-luan Cen, Jie-mei Cen, Wei-ning Cen, Jia-yi Li, Mei-wei Li, Ting-qing Gan, Xiao-hua Hu, Gang Chen   +8 more
doaj   +1 more source

A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies

Traffic, Volume 27, Issue 3, September 2026.
Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby, Gunjan Misri, Naava Naslavsky, Steve Caplan   +3 more
wiley   +1 more source