Results 31 to 40 of about 21,064 (212)
MicroRNA-210 and Endoplasmic Reticulum Chaperones in the Regulation of Chemoresistance in Glioblastoma [PDF]
Journal of Cancer, 2015 Glioblastoma multiforme (GBM) is the commonest primary brain tumour in adults characterized by relentless recurrence due to resistance towards the standard chemotherapeutic agent temozolomide (TMZ). Prolyl 4-hydroxylase, beta polypeptide (P4HB), an endoplasmic reticulum (ER) chaperone, is known to be upregulated in TMZ-resistant GBM cells.
Ho, ASW +8 more
openaire +4 more sources
Up-Regulation of Cell-Free MicroRNA-1 and MicroRNA-221-3p Levels in Patients with Myocardial Infarction Undergoing Coronary Angiography [PDF]
Advanced Pharmaceutical Bulletin, 2021 Purpose: Myocardial infarction (MI), known as a multifactorial disease, remains the predominant cause of mortality and sudden deaths annually. The current study aimed to measure the expression of microRNA-1 and microRNA-221-3p in MI patients. Methods: In
Fatemeh Mansouri +1 more
doaj +1 more source
Function and mechanism of microRNA‑210 in acute cerebral infarction
Experimental and Therapeutic Medicine, 2017 Acute cerebral infarction (ACI) is a common cerebrovascular disease. Previous studies have indicated that microRNAs (miRs) are aberrantly expressed in patients with ACI. However, the functions of miRs in the pathogenesis of ACI still require further investigation.
Wang, Jun, Zhang, Yuezhan, Xu, Feng
openaire +3 more sources
PLoS ONE, 2015 Expression and regulation of microRNAs is an emerging issue in erythroid differentiation and globin gene expression in hemoglobin disorders. In the first part of this study microarray analysis was performed both in mithramycin-induced K562 cells and ...
Nicoletta Bianchi +10 more
doaj +1 more source
Impact of Hypoxia-Induced miR-210 on Pancreatic Cancer
Current Issues in Molecular Biology, 2023 Pancreatic cancer (PC) poses significant clinical challenges, with late-stage diagnosis and limited therapeutic options contributing to its dismal prognosis.
Mutian Lian +2 more
doaj +1 more source
MicroRNA-210 Regulates Dendritic Morphology and Behavioural Flexibility in Mice
Molecular Neurobiology, 2020 MicroRNAs are known to be critical regulators of neuronal plasticity. The highly conserved, hypoxia-regulated microRNA-210 (miR-210) has been shown to be associated with long-term memory in invertebrates and dysregulated in neurodevelopmental and neurodegenerative disease models. However, the role of miR-210 in mammalian neuronal function and cognitive
Michelle Watts +4 more
openaire +6 more sources
Molecular Therapy: Nucleic Acids, 2018 We previously found that 19 microRNAs (miRNAs) significantly increased in the sera of hepatocellular carcinoma (HCC) patients. Here, we evaluated whether these miRNAs were secreted by HCC cells and contributed to tumor angiogenesis. High level of miR-210-
Xue-Jia Lin +6 more
doaj +1 more source
Intact feto-placental growth in microRNA-210 deficient mice [PDF]
Placenta, 2016 MicroRNA-210 (miR-210) has been implicated in homeostatic adaptation during hypoxia. We hypothesized that miR-210 deficiency impacts feto-placental growth. As expected, mir-210 knockout (ko) mice exhibited markedly reduced placental miR-210 expression, compared to wild-type (wt) mice.
Kamil Krawczynski +3 more
openaire +2 more sources
MicroRNA-210 promotes angiogenesis in acute myocardial infarction
Molecular Medicine Reports, 2018 MicroRNA-210 (miRNA-210) has been reported to be associated with angiogenesis and may serve important roles in acute myocardial infarction (AMI), which remain unclear. The present study sought to evaluate the efficacy of miRNA‑210 in AMI and to examine the potential associated mechanisms. AMI models were established in Sprague‑Dawley rats.
Fan, Zhong-Guo +6 more
openaire +3 more sources
Role of microRNA-210 in human intervertebral disc degeneration
Experimental and Therapeutic Medicine, 2016 The present study aimed to investigate the role of microRNA (miR)-210 in the development of intervertebral disc degeneration (IDD). Human nucleus pulposus (NP) samples were collected from patients with scoliosis and IDD (n=12 each) as the scoliosis control and IDD groups, respectively.
DA-Ying, Zhang +4 more
openaire +3 more sources