Results 31 to 40 of about 22,552 (272)

Function and mechanism of microRNA‑210 in acute cerebral infarction

Experimental and Therapeutic Medicine, 2017
Acute cerebral infarction (ACI) is a common cerebrovascular disease. Previous studies have indicated that microRNAs (miRs) are aberrantly expressed in patients with ACI. However, the functions of miRs in the pathogenesis of ACI still require further investigation.
Jun Wang, Yuezhan Zhang, Feng Xu
openalex   +5 more sources

MicroRNA-210: A unique and pleiotropic hypoxamir [PDF]

Cell Cycle, 2010
Inadequate oxygen availability or hypoxia induces a complex and still incompletely understood set of adaptations that influence cellular survival and function. Many of these adaptations are directly controlled by a master transcription factor, hypoxia inducible factor-alpha (HIF-α).
Stephen Y, Chan, Joseph, Loscalzo
openaire   +2 more sources

Upregulated Angiogenesis Is Incompetent to Rescue Dilated Cardiomyopathy Phenotype in Mice

Cells, 2021
Dilated cardiomyopathy (DCM) is characterized by pathologic cardiac remodeling resulting in chambers enlargement and impaired heart contractility. Previous reports and our in-silico analysis support the association of DCM phenotype and impaired tissue ...
Mohammed Arif, Perwez Alam, Rafeeq PH Ahmed, Raghav Pandey, Hafeez M Faridi, Sakthivel Sadayappan   +5 more
doaj   +1 more source

Estimated level of plasma micro RNA-210 in beta thalassemia patients and its relation to hemoglobin F level and disease severity

Journal of Applied Hematology, 2023
BACKGROUND: Beta-thalassemia is an autosomal recessive hereditary blood disorder occurs due to absent or diminished β-globin chains synthesis. The transformation from fetal to adult in globin synthesis is controlled by different mechanisms; one of those ...
Homam M Sharshera, Shereen M El Maghraby, Shaimaa A Aglan, Irene L Mikhael, Ola A Balbaa   +4 more
doaj   +1 more source

Angiogenic microRNA‐210 is present in cells surrounding osteonecrosis [PDF]

Journal of Orthopaedic Research, 2012
AbstractA role of microRNAs (miRNAs), which are ∼22‐nucleotide non‐coding RNAs, has recently been recognized in human diseases. The objective of this study was to identify the expression pattern of miRNA (miR)‐210, known to be associated with angiogenesis, in bone from patients with osteonecrosis (ON) of the femoral head.
Keiichiro, Yamasaki, Tomoyuki, Nakasa, Shigeru, Miyaki, Takuma, Yamasaki, Yuji, Yasunaga, Mitsuo, Ochi   +5 more
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MicroRNA‐210 Decreases heme Levels by Targeting Ferrochelatase in Cardiomyocytes [PDF]

Journal of the American Heart Association, 2013
Background Micro RNA ‐210 (miR‐210) increases in hypoxia and regulates mitochondrial respiration through modulation of iron‐sulfur cluster assembly proteins ( ISCU 1/2), a protein that is involved in Fe/S cluster synthesis.
Aijun Qiao, Arineh Khechaduri, R. Kannan Mutharasan, Rongxue Wu, Varun Nagpal, Hossein Ardehali   +5 more
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Neuroprotective Effects of MicroRNA-210 on Hypoxic-Ischemic Encephalopathy [PDF]

BioMed Research International, 2013
Objectives. To reveal the effect of microRNA-210 on cell apoptosis caused by HIE.Methods. Postnatal day 7 rats after HI injury were intraventricularly injected with microRNA-210 mimic, microRNA-210 inhibitor, or physiological saline. 72 h after the injection, rats were sacrificed and the left hemispheres were collected. The expression level of microRNA-
Qiu, Jie, Zhou, Xiao-yu, Zhou, Xiao-guang, Cheng, Rui, Liu, Hai-ying, Li, Yong   +5 more
openaire   +2 more sources

MicroRNA-210 regulates mitochondrial free radical response to hypoxia and krebs cycle in cancer cells by targeting iron sulfur cluster protein ISCU. [PDF]

PLoS ONE, 2010
Hypoxia in cancers results in the upregulation of hypoxia inducible factor 1 (HIF-1) and a microRNA, hsa-miR-210 (miR-210) which is associated with a poor prognosis.In human cancer cell lines and tumours, we found that miR-210 targets the mitochondrial ...
Elena Favaro, Anassuya Ramachandran, Robert McCormick, Harriet Gee, Christine Blancher, Meredith Crosby, Cecilia Devlin, Christopher Blick, Francesca Buffa, Ji-Liang Li, Borivoj Vojnovic, Ricardo Pires das Neves, Peter Glazer, Francisco Iborra, Mircea Ivan, Jiannis Ragoussis, Adrian L Harris   +16 more
doaj   +1 more source

Hypoxia-inducible MiR-210 is an independent prognostic factor and contributes to metastasis in colorectal cancer. [PDF]

PLoS ONE, 2014
MicroRNA-210 (miR-210), the master hypoxamir, plays pleiotropic roles in certain cancers; however, its role in the development of human colorectal cancer remains unclear.
Ailin Qu, Lutao Du, Yongmei Yang, Hui Liu, Juan Li, Lili Wang, Yimin Liu, Zhaogang Dong, Xin Zhang, Xiumei Jiang, Haiyan Wang, Zewu Li, Guixi Zheng, Chuanxin Wang   +13 more
doaj   +1 more source

microRNA expression in peripheral blood cells following acute ischemic stroke and their predicted gene targets. [PDF]

, 2014
BackgroundmicroRNA (miRNA) are important regulators of gene expression. In patients with ischemic stroke we have previously shown that differences in immune cell gene expression are present.
Ander, Bradley P, Jickling, Glen C, Liu, Dazhi, Noblett, Dylan, Stamova, Boryana, Zhan, Xinhua   +5 more
core   +7 more sources