Results 61 to 70 of about 21,599 (235)
Hypoxia-regulated MicroRNA-210 in neuronal plasticity [PDF]
, 2018 In recent years increasing evidence has established microRNAs as critical regulators of neuronal development and plasticity that can act locally, in an activity-dependent manner. The hypoxia-regulated microRNA-210 (miR-210) is a highly conserved miRNA, widely studied for its role in regulating cellular response to low oxygen conditions. Previously, our
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Small Molecule Inhibition of microRNA-210 Reprograms an Oncogenic Hypoxic Circuit [PDF]
Journal of the American Chemical Society, 2017 A hypoxic state is critical to the metastatic and invasive characteristics of cancer. Numerous pathways play critical roles in cancer maintenance, many of which include noncoding RNAs such as microRNA (miR)-210 that regulates hypoxia inducible factors (HIFs). Herein, we describe the identification of a small molecule named Targapremir-210 that binds to
Matthew G. Costales +5 more
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Frontiers in Cellular Neuroscience, 2019 Endothelial progenitor cells (EPCs) are multipotential stem cells considered to have immense clinical value for revascularization. However, the clinical application of EPCs has been hampered by their clinical potency in ischemic anoxic environments. This
Wen-Jing Lu +9 more
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Deep-sequencing of endothelial cells exposed to hypoxia reveals the complexity of known and novel microRNAs [PDF]
, 2012 In order to understand the role of microRNAs (miRNAs) in vascular physiopathology, we took advantage of deep-sequencing techniques to accurately and comprehensively profile the entire miRNA population expressed by endothelial cells exposed to hypoxia ...
Brini, Elena +11 more
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MicroRNA-210 negatively regulates the radiosensitivity of nasopharyngeal carcinoma cells
Molecular Medicine Reports, 2017 Radiotherapy is one of the primary methods of treatment of malignant tumors, however, resistance to radiation is a major problem. The reasons for the radioresistance are still poorly understood. However, it is generally accepted that microRNAs (miRNAs or miRs) can regulate the radiosensitivity of tumors.
Bo-Yi, Li +6 more
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Plasma microrna expression profile for reduced ejection fraction in dilated cardiomyopathy
Scientific Reports, 2021 The left ventricular (LV) ejection fraction (EF) is key to prognosis in dilated cardiomyopathy (DCM). Circulating microRNAs have emerged as reliable biomarkers for heart diseases, included DCM.
Maria Calderon-Dominguez +7 more
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MicroRNA-210 Knockout Alters Dendritic Density and Behavioural Flexibility [PDF]
, 2019 AbstractMicroRNAs exert post-transcriptional control over eukaryotic genomes and are integral for regulating complex functions in neurodevelopment, neuroplasticity and cognitive processing. The microRNA-210 (miR-210) is a highly-conserved, hypoxia-regulated miRNA that has been shown to be dysregulated in Alzheimer’s Disease.
Watts, Michelle +4 more
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Advanced Science, EarlyView.Stroke‐induced lactate accumulation promotes p300‐mediated lactylation of methyl‐CpG binding protein 2 (MeCP2) at lysine 210, which reprograms microglial metabolism toward glycolysis and activates the hexokinase 2 (HK2)/mTOR axis. This cascade promotes proinflammatory responses and impairs neurofunctional outcomes.
Zengyu Zhang +12 more
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BMC Medical Genetics, 2020 Background This study was aimed to investigate the regulatory role of microRNA-210 (miRNA-210) on the progression of liver cancer and Hepatitis B virus (HBV)-associated liver cancer.
Xiaojie Li, Mei Yuan, Lu Song, Yan Wang
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Association of microRNAs and pathologic response to preoperative chemotherapy in triple negative breast cancer: preliminary report [PDF]
, 2014 Triple negative breast cancer (TNBC) has caught the attention of oncologists worldwide because of poor prognosis and paucity of targeted therapies. Gene pathways have been widely studied, but less is known about epigenetic factors such as microRNAs ...
Choi, Young Eun +11 more
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