Results 41 to 50 of about 282,025 (323)
Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation [PDF]
Leukemia. 24 (2010) 460-6, 2010 Acute myeloid leukemia (AML) involves a block in terminal differentiation of the myeloid lineage and uncontrolled proliferation of a progenitor state. Using phorbol myristate acetate (PMA), it is possible to overcome this block in THP-1 cells (an M5-AML containing the MLL-MLLT3 fusion), resulting in differentiation to an adherent monocytic phenotype ...
arxiv +1 more source
Current Drug Targets, 2010 MicroRNAs are endogenously expressed small non-coding RNAs that regulate gene expression on the posttranscriptional level. During the last years microRNAs have emerged as key regulators of several physiological and pathophysiological processes in the vascular wall.
Angelika Bonauer +2 more
openaire +3 more sources
Systematic analysis reveals key microRNAs as diagnostic and prognostic factors in progressive stages of lung cancer [PDF]
arXiv, 2022 MicroRNAs play an indispensable role in numerous biological processes ranging from organismic development to tumor progression.In oncology,these microRNAs constitute a fundamental regulation role in the pathology of cancer that provides the basis for probing into the influences on clinical features through transcriptome data.
arxiv
Prediction of miRNA-disease associations with a vector space model [PDF]
Scientific Reports, Nature Publishing Group, 2016, 6, pp.27036, 2016 MicroRNAs play critical roles in many physiological processes. Their dysregulations are also closely related to the development and progression of various human diseases, including cancer. Therefore, identifying new microRNAs that are associated with diseases contributes to a better understanding of pathogenicity mechanisms.
arxiv +1 more source
Geometric Mean of 5S rRNA and MiR-16 As A Suitable Normalizer In Esophageal Cancer [PDF]
Journal of Cell and Molecular Research, 2016 Esophageal squamous cell carcinoma (ESCC) is a deadly cancer with poor prognosis. In this regard, early diagnosis is of vital importance to cure the tumor in its early stages.
Samaneh Khazaei +2 more
doaj +1 more source
Specific microRNAs and heart failure: time for the next step toward application?
Biomedical Papers, 2022 A number of microRNAs are involved in the pathophysiological events associated with heart disease. In this review, we discuss miR-21, miR-1, miR-23a, miR-142-5p, miR-126, miR-29, miR-195, and miR-499 because they are most often mentioned as important ...
Radka Sigutova +4 more
doaj +1 more source
Nucleic Acids Research, 2004 The miRNA Registry provides a service for the assignment of miRNA gene names prior to publication. A comprehensive and searchable database of published miRNA sequences is accessible via a web interface (http://www.sanger.ac.uk/Software/Rfam/mirna/), and all sequence and annotation data are freely available for download.
openaire +4 more sources
MicroRNAs and autoimmunity [PDF]
Current Opinion in Immunology, 2012 The role of microRNAs (miRNAs) in the regulation of many physiological and pathological processes has been intensely studied in recent years. Some miRNAs, such as miR-146a and miR-182, play a dominant role in the regulation of the innate and adaptive immune responses, respectively.
A. Ceribelli, M. Satoh, E. K. Chan
openaire +2 more sources
Redox Biology, 2023 Acute kidney injury (AKI) presents a daunting challenge with limited therapeutic options. To explore the contribution of N6-methyladenosine (m6A) in AKI development, we have investigated m6A-modified mRNAs within renal tubular cells subjected to injuries
Wenwen Yang +8 more
doaj
Acute responses of circulating microRNAs to low-volume sprint interval cycling
Frontiers in Physiology, 2015 Low-volume high-intensity interval training is an efficient and practical method of inducing physiological responses in various tissues to develop physical fitness and may also change the expression of circulating microRNAs (miRNAs).
Shu Fang eCui +10 more
doaj +1 more source