Results 41 to 50 of about 498,599 (357)

Extracellular and intracellular microRNAs in pancreatic cancer: from early diagnosis to reducing chemoresistance

ExRNA, 2019
Pancreatic cancer (PaC) is one of the most aggressive malignancies. The dismal survival rate of PaC patients is mainly due to the late diagnosis and their resistance to conventional chemotherapies.
Xiaohong Jiang, Dongxia Hou, Zhe Wei, Shasha Zheng, Yujing Zhang, Jing Li   +5 more
doaj   +1 more source

ALOX5 deficiency contributes to bladder cancer progression by mediating ferroptosis escape

Cell Death and Disease, 2023
Ferroptosis is an iron-dependent form of regulated cell death driven by the lethal lipid peroxides. Previous studies have demonstrated that inducing ferroptosis holds great potential in cancer therapy, especially for patients with traditional therapy ...
Tianyao Liu, Xinyan Xu, Jiazheng Li, Ming Bai, Wenjie Zhu, Yanqing Liu, Siyang Liu, Zihan Zhao, Tianhang Li, Ning Jiang, Yuhao Bai, Qingyang Jin, Yulin Zhang, Yufeng Zheng, Shengkai Zhou, Shoubin Zhan, Ying Sun, Gaoli Liang, Yang Luo, Xi Chen, Hongqian Guo, Rong Yang   +21 more
doaj   +1 more source

MicroRNAs-Proteomic Networks Characterizing Human Medulloblastoma-SLCs [PDF]

, 2016
Medulloblastoma (MB) is the most common malignant brain tumor of pediatric age and is characterized by cells expressing stem, astroglial, and neuronal markers.
Alfano, Vincenzo, Besharat, ZEIN MERSINI, Carai, Andrea, Catanzaro, Giuseppina, Ferretti, Elisabetta, Garg, Neha, Locatelli, Franco, Mastronuzzi, Angela, Miele, Evelina, Pieroni, Luisa, Po, Agnese, Ronci, Maurizio, Screpanti, Isabella, Urbani, Andrea   +13 more
core   +4 more sources

Emerging role of extracellular microRNAs and lncRNAs

ExRNA, 2019
The discovery of extracellular non-coding RNAs, including microRNAs (miRNAs) and long non-coding RNAs (lncRNAs), has dramatically altered our understanding of the role RNA plays in organisms.
Geyu Zhou, Xi Chen
doaj   +1 more source

miRNAs as Regulators of Antidiabetic Effects of Fucoidans [PDF]

, 2019
open access articleDiabetes mellitus is a metabolic disease with a high mortality rate worldwide. MicroRNAs (miRNAs), and other small noncoding RNAs, serve as endogenous gene regulators through binding to specific sequences in RNA and modifying gene ...
Arroo, R. R. J., El-Seed, Hesham, Ismail, Amin, Lai, Shanshan, Liu, Dan, Wu, Desheng, Xiao, Jianbo, Zhao, Chao, Zou, Xiaobo   +8 more
core   +1 more source

The Jun/miR-22/HuR regulatory axis contributes to tumourigenesis in colorectal cancer

Molecular Cancer, 2018
Background Colorectal cancer (CRC) is a severe health problem worldwide. Clarifying the mechanisms for the deregulation of oncogenes and tumour suppressors in CRC is vital for its diagnosis, treatment, prognosis and prevention.
Yanqing Liu, Xiaorui Chen, Rongjie Cheng, Fei Yang, Mengchao Yu, Chen Wang, Shufang Cui, Yeting Hong, Hongwei Liang, Minghui Liu, Chihao Zhao, Meng Ding, Wu Sun, Zhijian Liu, Feng Sun, Chenyu Zhang, Zhen Zhou, Xiaohong Jiang, Xi Chen   +18 more
doaj   +1 more source

Serum microRNA array analysis identifies miR-140-3p, miR-33b-3p and miR-671-3p as potential osteoarthritis biomarkers involved in metabolic processes. [PDF]

, 2017
Background: MicroRNAs (miRNAs) in circulation have emerged as promising biomarkers. In this study, we aimed to identify a circulating miRNA signature for osteoarthritis (OA) patients and in combination with bioinformatics analysis to evaluate the utility
A Brazma, A Nan, A Okuhara, A Turchinovich, B Aryal, B Mayr, B Sharif, B Zhang, BM Bolstad, BM Kuhn, BM Mayr, C Beyer, C Chen, C Guay, C Taurino, CL Andersen, D Dlouha, D Iliopoulos, D Zhang, DT Felson, F Kostopoulou, FE Nicolas, G Dennis Jr, G Li, G Tardif, GD Miles, GR Sondag, GS Lien, H Causton, JB van Meurs, JD Storey, JD Storey, KC Vickers, L Qi, M Cross, M Parrizas, MB Goldring, MC Hochberg, MD Paraskevopoulou, MP Gantier, OF Laterza, Q Zhuo, R Gernapudi, RF Loeser, RI Gregory, S Kluzek, S Kumar, S Miyaki, T Thomou, TA Karlsen, VM Borgonio Cuadra, W Cleveland, WM Reichmann, X Chen, X Chen, X Tan, X Wang, Y Klipper-Aurbach, Y Zhang, YH Li   +59 more
core   +2 more sources

ING5 suppresses breast cancer progression and is regulated by miR-24

Molecular Cancer, 2017
Background The inhibitor of growth (ING) gene family of tumor suppressors is involved in multiple cellular functions such as cell cycle regulation, apoptosis, and chromatin remodeling.
Shufang Cui, Xin Liao, Chao Ye, Xin Yin, Minghui Liu, Yeting Hong, Mengchao Yu, Yanqing Liu, Hongwei Liang, Chen-Yu Zhang, Xi Chen   +10 more
doaj   +1 more source

LINC00460-miR-149-5p/miR-150-5p-Mutant p53 Feedback Loop Promotes Oxaliplatin Resistance in Colorectal Cancer

Molecular Therapy: Nucleic Acids, 2020
Oxaliplatin resistance is a major challenge in the clinical treatment for advanced colorectal cancer (CRC). Long non-coding RNAs (lncRNAs) are involved in tumorigenesis and progression as critical regulators, while their potential roles in ...
Xiangfeng Meng, Wu Sun, Jing Yu, Yu Zhou, Yuanyuan Gu, Jiayi Han, Likun Zhou, Xiaohong Jiang, Chen Wang   +8 more
doaj   +1 more source

Identification of an allatostatin C signaling system in mollusc Aplysia

Scientific Reports, 2022
Neuropeptides, as pervasive intercellular signaling molecules in the CNS, modulate a variety of behavioral systems in both protostomes and deuterostomes.
Hui-Min Jiang, Zhe Yang, Ying-Yu Xue, Hui-Ying Wang, Shi-Qi Guo, Ju-Ping Xu, Ya-Dong Li, Ping Fu, Xue-Ying Ding, Ke Yu, Wei-Jia Liu, Guo Zhang, Jian Wang, Hai-Bo Zhou, Abraham J. Susswein, Jian Jing   +15 more
doaj   +1 more source