Results 51 to 60 of about 498,599 (357)

Reduced brain UCP2 expression mediated by microRNA-503 contributes to increased stroke susceptibility in the high-salt fed stroke-prone spontaneously hypertensive rat [PDF]

, 2017
UCP2 maps nearby the lod score peak of STR1-stroke QTL in the SHRSP rat strain. We explored the potential contribution of UCP2 to the high-salt diet (JD)-dependent increased stroke susceptibility of SHRSP.
Baima, Simona, Bianchi, Franca, Cotugno, Maria, D'Esposito, Maurizio, Fioriniello, Salvatore, Forte, Maurizio, Gelosa, Paolo, Madonna, Michele, Marchitti, Simona, Morelli, Giorgio, Ragione, Floriana Della, Rubattu, Speranza Donatella, Sciarretta, Sebastiano, Sironi, Luigi, Stanzione, Rosita, Volpe, Massimo   +15 more
core   +1 more source

MicroRNA-34, microRNA-130, microRNA-148, microRNA-181, microRNA-194 and microRNA-605 expression in colon cancer tissue

South Russian Journal of Cancer
Purpose of the study. Determination of the expression of microRNA‑34, microRNA‑130, microRNA‑148, microRNA‑181, microRNA‑194 and microRNA‑605 in colon tumor tissue depending on the clinical and morphological features of the tumor and the effectiveness of treatment.Materials and methods.
D. I. Azovsky, S. G. Afanasyev, A. V. Avgustinovich, L. V. Spirina, I. V. Kovaleva, A. B. Zinnurova, V. A. Belova   +6 more
openaire   +2 more sources

Metazoan MicroRNAs [PDF]

Cell, 2018
MicroRNAs (miRNAs) are ∼22 nt RNAs that direct posttranscriptional repression of mRNA targets in diverse eukaryotic lineages. In humans and other mammals, these small RNAs help sculpt the expression of most mRNAs. This article reviews advances in our understanding of the defining features of metazoan miRNAs and their biogenesis, genomics, and evolution.
openaire   +4 more sources

Viral infection and neurological disorders—potential role of extracellular nucleotides in neuroinflammation

ExRNA, 2019
Neuroinflammation can be induced under several conditions including pathogen infection such as virus. As the main immune cells in brain, microglia activation plays a pivotal role in neuroinflammation by responding to the invading pathogens (viral DNA/RNA)
Liang Li, Susu Mao, Jin Wang, Xin Ding, Jane Y. Zen   +4 more
doaj   +1 more source

Characterization of an Aplysia vasotocin signaling system and actions of posttranslational modifications and individual residues of the ligand on receptor activity

Frontiers in Pharmacology, 2023
The vasopressin/oxytocin signaling system is present in both protostomes and deuterostomes and plays various physiological roles. Although there were reports for both vasopressin-like peptides and receptors in mollusc Lymnaea and Octopus, no precursor or
Ju-Ping Xu, Xue-Ying Ding, Shi-Qi Guo, Hui-Ying Wang, Wei-Jia Liu, Hui-Min Jiang, Ya-Dong Li, Ping Fu, Ping Chen, Yu-Shuo Mei, Guo Zhang, Hai-Bo Zhou, Hai-Bo Zhou, Jian Jing, Jian Jing, Jian Jing   +15 more
doaj   +1 more source

Decoding transcription and microRNA-mediated translation control in Drosophila development [PDF]

, 2010
The spatio-temporal regulation of gene expression lies at the heart of animal development. In this article we present an overview of our recent work to apply systems biological approaches to the study of transcription and microRNA-mediated translation ...
Gaul, Ulrike
core   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Human cytomegalovirus-encoded microRNAs expression profile in plasma of patients with aortic dissection

Journal of Cardiothoracic Surgery, 2023
Background Aortic dissection (AD) is a rare disease with high mortality for which no effective diagnostic biomarkers are available. Human cytomegalovirus (HCMV) infection is an important cause of the occurrence and progression of many diseases, but the ...
Yongqing Cheng, Yufan Du, Qi Wang, Qinghe Lv, Yunxin Xue, Weihong Zhou, Chenyu Zhang, Xi Chen, Dongjin Wang   +8 more
doaj   +1 more source

Virulence Factors of the Fungal Pathogen Stagonospora nodorum Manipulate Hormonal Signaling Pathways in Triticum aestivum L. by Regulating Host Plant MicroRNA Expressions

Frontiers in Bioscience-Elite, 2023
Background: Currently, the role of microRNAs in plant immune responses is being actively studied. Thus, our aim was to research the effect of Stagonospora nodorum (Berk.) NEs SnToxA and SnTox3 on the expression of miRNAs involved in the wheat–S.
Tatyana Nuzhnaya, Svetlana Veselova, Guzel Burkhanova, Igor Maksimov   +3 more
doaj   +1 more source

Differential expression of microRNA-206 and its target genes in pre-eclampsia [PDF]

, 2015
Objectives: Pre-eclampsia is a multi-system disease that significantly contributes to maternal and fetal morbidity and mortality. In this study, we used a non-biased microarray approach to identify novel circulating miRNAs in maternal plasma that may be ...
Akehurst, Christine, Beattie, Wendy, Brown, Catriona E., Carty, David M., Delles, Christian, Forrest, Rachel, Freeman, Dilys J., McBride, Martin W., McClure, John D., Robinson, Scott W., Sharafetdinova, Liliia, Small, Heather, Work, Lorraine M.   +12 more
core   +1 more source