Results 71 to 80 of about 31,514 (218)

Versatile microRNA biogenesis in animals and their viruses [PDF]

RNA Biology, 2014
MicroRNAs (miRNAs) are ubiquitous gene regulators that modulate essential cellular processes at the post-transcriptional level. In metazoans and their viruses, most miRNAs are produced from hairpin-containing primary transcripts that are sequentially cleaved by nuclear Drosha and cytoplasmic Dicer. In the last decade, alternative mechanisms that bypass
Mingyi, Xie, Joan A, Steitz
openaire   +2 more sources

Biomarkers of Sarcopenia: Current Status and Future Perspectives

AGING MEDICINE, EarlyView.
In this review, we summarize the various biomarkers discovered in recent years, including biochemical, imaging, and physical testing markers. We analyze their advantages and disadvantages and propose potential ways to improve the diagnostic accuracy of biomarkers, as well as future research directions.
Bijin Luo, Wenhan Li, Yi Zhang, Mengchen Liu, Kemeng Zhang, Sui Huang, Ping He   +6 more
wiley   +1 more source

Metabolic and circadian inputs encode anticipatory biogenesis of hepatic fed microRNAs

Life Science Alliance
Unravelling molecular and physiological mechanisms that couple circadian and metabolic cues to regulate anticipatory miR biogenesis during fed-fast-refed cycles in the liver.
Sandra Usha Satheesan, Shreyam Chowdhury, Ullas Kolthur-Seetharam   +2 more
doaj   +1 more source

Genetic variation and RNA structure regulate microRNA biogenesis

Nature Communications, 2017
A single variant in mir-30c-1 found in breast and gastric cancer patients leads to increased levels of mature miRNA. Here the authors show that this variant alters the RNA structure of this pri-miRNA leading to enhanced binding of SRSF3 and increased ...
Noemi Fernandez, Ross A. Cordiner, Robert S. Young, Nele Hug, Sara Macias, Javier F. Cáceres   +5 more
doaj   +1 more source

Impaired expression of DICER, DROSHA, SBDS and some microRNAs in mesenchymal stromal cells from myelodysplastic syndrome patients

Haematologica, 2012
Background Recent findings suggest that a specific deletion of Dicer1 in mesenchymal stromal cell-derived osteoprogenitors triggers several features of myelodysplastic syndrome in a murine model.
Carlos Santamaría, Sandra Muntión, Beatriz Rosón, Belén Blanco, Olga López-Villar, Soraya Carrancio, Fermín M. Sánchez-Guijo, María Díez-Campelo, Stela Alvarez-Fernández, María E. Sarasquete, Javier de las Rivas, Marcos González, Jesús F. San Miguel, María Consuelo del Cañizo   +13 more
doaj   +1 more source

Plant microRNAs: Biogenesis, Homeostasis, and Degradation [PDF]

Frontiers in Plant Science, 2019
MicroRNAs (miRNAs), a class of endogenous, tiny, non-coding RNAs, are master regulators of gene expression among most eukaryotes. Intracellular miRNA abundance is regulated under multiple levels of control including transcription, processing, RNA modification, RNA-induced silencing complex (RISC) assembly, miRNA-target interaction, and turnover.
Junli Wang, Jun Mei, Guodong Ren
openaire   +3 more sources

Review of the Molecular and Developmental Basis of Myhre Syndrome, Bench Research

American Journal of Medical Genetics Part C: Seminars in Medical Genetics, EarlyView.
ABSTRACT Myhre syndrome (MS) is a connective‐tissue disorder within the acromelic dysplasia spectrum. It is characterized by congenital craniofacial, skeletal, cutaneous anomalies, respiratory, cardiovascular along with intellectual disability, deafness, and progressive fibrosis.
Camille Viaut, Valerie Cormier‐Daire
wiley   +1 more source

Posttranscriptional Regulation of MicroRNA Biogenesis in Animals [PDF]

Molecular Cell, 2010
MicroRNAs (miRNAs) control gene expression in animals, plants, and unicellular eukaryotes by promoting degradation or repressing translation of target mRNAs. miRNA expression is often tissue specific and developmentally regulated, and regulation occurs both transcriptionally and posttranscriptionally.
Siomi, Haruhiko, Siomi, Mikiko C.
openaire   +2 more sources

USB1 deficiency disrupts neutrophil maturation via RNA dysregulation independent of global pre‐mRNA splicing

Animal Models and Experimental Medicine, EarlyView.
This graphical abstract illustrates the essential role of USB1 in neutrophil maturation. In normal myeloid cells, USB1 acts as an RNA exonuclease, trimming RNA tails to maintain proper RNA network function, which supports the differentiation of myeloid progenitor cells into mature neutrophils.
Hang Li, Guiying Shi, Jiaming Tang, Yiying Huang, Jie Wang, Xuepei Lei, Lin Bai   +6 more
wiley   +1 more source

Exosome‐mediated gut–brain axis signaling in neurodegenerative diseases: Mechanisms, experimental evidence, and therapeutic perspectives—A narrative review

Animal Models and Experimental Medicine, EarlyView.
The gut–brain axis is a bidirectional communication network between the intestines and brain, mediated by gut microbiota and exosomes, that regulates neuroinflammation, protein aggregation, and neuronal health processes central to neurodegenerative diseases.
Waheeb Sami Aggad, Rakesh Ghosh, Hailah M. Almohaimeed, Zuhair M. Mohammedsaleh, Fayez M. Saleh, Amany I. Almars, S. Renuka Jyothi, Rajashree Panigrahi, Ajoy Kumer, Bikram Dhara   +9 more
wiley   +1 more source