Clusters of microRNAs emerge by new hairpins in existing transcripts [PDF]
, 2013 Genetic linkage may result in the expression of multiple products from a polycistronic transcript, under the control of a single promoter. In animals, protein-coding polycistronic transcripts are rare. However, microRNAs are frequently clustered in the genomes of animals, and these clusters are often transcribed as a single unit.
Alberts +66 more
arxiv +5 more sources
Induction of microRNAs, mir-155, mir-222, mir-424 and mir-503, promotes monocytic differentiation through combinatorial regulation [PDF]
Leukemia. 24 (2010) 460-6, 2010 Acute myeloid leukemia (AML) involves a block in terminal differentiation of the myeloid lineage and uncontrolled proliferation of a progenitor state. Using phorbol myristate acetate (PMA), it is possible to overcome this block in THP-1 cells (an M5-AML containing the MLL-MLLT3 fusion), resulting in differentiation to an adherent monocytic phenotype ...
A Astrinidis +51 more
arxiv +5 more sources
A population-based statistical approach identifies parameters characteristic of human microRNA-mRNA interactions [PDF]
, 2004 BACKGROUND: MicroRNAs are ~17–24 nt. noncoding RNAs found in all eukaryotes that degrade messenger RNAs via RNA interference (if they bind in a perfect or near-perfect complementarity to the target mRNA), or arrest translation (if the binding is ...
Smalheiser, Neil R, Torvik, Vetle I
core +5 more sources
MicroRNAs in type 2 diabetes mellitus: potential role of physical exercise [PDF]
Reviews in Cardiovascular Medicine, 2022 Type 2 diabetes mellitus (T2DM) is a multifactorial metabolic disease, and its prevalence has grown worldwide. Several pathophysiological processes contribute to the development, progression and aggravating of the disease, for example, decreased ...
Alex Cleber Improta-Caria +6 more
doaj +1 more source
Different microRNAs contribute to the protective effect of mesenchymal stem cell-derived microvesicles in LPS induced acute respiratory distress syndrome [PDF]
Iranian Journal of Basic Medical Sciences, 2021 Objective(s): The present study aimed to determine whether bone marrow mesenchymal stem cell-derived microvesicles (MSC MVs) were effective in restoring lung tissue structure, and to assess the potential role of miRNAs in the pathogenesis and progression
Xingcai Zhang +5 more
doaj +1 more source
Identification of Key microRNAs and Genes in Infantile Hemangiomas
Frontiers in Genetics, 2022 Infantile hemangiomas (IHs) are the most frequent vascular tumors that occur during infancy. Microribonucleic acids (miRNAs) have been demonstrated as critical regulators of gene expression in various diseases. However, the function of miRNAs in IH still
Cong Fu +4 more
doaj +1 more source
Small RNA Profile in Moso Bamboo Root and Leaf Obtained by High Definition Adapters [PDF]
, 2014 Moso bamboo (Phyllostachy heterocycla cv. pubescens L.) is an economically important fast-growing tree. In order to gain better understanding of gene expression regulation in this important species we used next generation sequencing to profile small RNAs
A Kozomara +57 more
core +9 more sources
Molecules, 2020 We previously showed that microwave assisted synthesis is the best method for the synthesis of naphthoquinone amino acid and chloride-naphthoquinone amino acid derivatives by a complete evaluation of reaction conditions such as stoichiometry, bases, and ...
Sergio Córdova-Rivas +9 more
doaj +1 more source
Frontiers in Genetics, 2021 Diabetic mellitus erectile dysfunction (DMED) is one of the most common complications of diabetes mellitus (DM), which seriously affects the self-esteem and quality of life of diabetics.
Haibo Xu +5 more
doaj +1 more source
Identification of altered microRNAs in retinas of mice with oxygen-induced retinopathy [PDF]
International Journal of Ophthalmology, 2019 AIM: To identify disease-related miRNAs in retinas of mice with oxygen-induced retinopathy (OIR), and to explore their potential roles in retinal pathological neovascularization.
Lu-Si Zhang +5 more
doaj +1 more source