Results 11 to 20 of about 283,349 (198)
Journal of Allergy and Clinical Immunology, 2018 MicroRNAs (miRNAs) are small endogenous RNAs that regulate gene-expression posttranscriptionally. MiRNA research in allergy is expanding because miRNAs are crucial regulators of gene expression and promising candidates for biomarker development.
Thomas X. Lu, Marc E. Rothenberg
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MicroRNA or Not MicroRNA? [PDF]
, 2011 The avalanche of next generation sequencing data has led to a rapid increase of annotated microRNAs in the last few years. Many of them are specific to individual species or rather narrow clades. A closer inspection of the current version of miRBase shows that dozens of entries conflict with other ncRNAs, in particular snoRNAs.With few exceptions ...
Steve Hoffmann +5 more
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MicroRNA: MicroRNAs Reach out into Dendrites [PDF]
Current Biology, 2006 A recent study has shown that miR-134, a brain-specific microRNA, is present in dendrites where it represses the local synthesis of the protein kinase LimK1; this is a novel form of translational regulation in dendrites and may have important physiological implications.
Tai, H., Schuman, E.
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MicroRNAs in Neurotoxicity [PDF]
Journal of Toxicology, 2012 MicroRNAs are gaining importance as regulators of gene expression with the capability to fine-tune and modulate cellular events. The complex network with their selective targets (mRNAs/genes) pave way for regulation of many physiological processes.
Kaur, P, Armugam, A, Jeyaseelan, K
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MicroRNAs in Development [PDF]
TSW Development & Embryology, 2006 Over 10 years ago, the lab of Victor Ambros cloned an unusual gene,lin-4, which encodes two small RNA transcripts[1]. In the past few years, hundreds more of these tiny transcripts, termed microRNAs (miRNAs), have been uncovered in over a dozen species.
Danielle M. Maatouk, Brian D. Harfe
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Modulation of microRNA Activity by Semi-microRNAs [PDF]
Frontiers in Genetics, 2012 The ribonuclease Dicer plays a central role in the microRNA pathway by catalyzing the formation of 19-24-nucleotide (nt) long microRNAs. Subsequently incorporated into Argonaute 2 (Ago2) effector complexes, microRNAs are known to regulate messenger RNA (mRNA) translation.
Preethi H. Gunaratne +6 more
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Journal of Thrombosis and Haemostasis, 2015 Epidemiologic studies have revealed that modification of the levels of individual components of the hemostatic system may have effects on the development of thrombosis or hemorrhage. To maintain the necessary equilibrium, the hemostatic system is finely regulated.
Teruel-Montoya, R. +2 more
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Most mammalian mRNAs are conserved targets of microRNAs.
Genome Research, 2008 MicroRNAs (miRNAs) are small endogenous RNAs that pair to sites in mRNAs to direct post-transcriptional repression. Many sites that match the miRNA seed (nucleotides 2-7), particularly those in 3' untranslated regions (3'UTRs), are preferentially ...
Robin C. Friedman +3 more
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An overview of microRNAs. [PDF]
Advanced Drug Delivery Reviews, 2015 The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in molecular biology. There are now over 2000 miRNAs that have been discovered in humans and it is believed that they collectively regulate one third of the genes in the genome.
S. Hammond
semanticscholar +4 more sources
Evaluation of the Sensitivity and Specificity of MiRNAs in Discriminating Oral Squamous Cell Carcinoma: A Systematic Review and Meta-analysis [PDF]
International Journal of Scientific Research in Dental and Medical Sciences, 2023 Background and aim: Approximately 90% of all oral malignant tumors are squamous cell carcinomas. This study aims to evaluate the sensitivity and specificity of miRNAs in discriminating oral squamous cell carcinoma.
Ali Salehi +4 more
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