Assessment of Circulating MicroRNAs for the Diagnosis and Disease Activity Evaluation in Patients with Ulcerative Colitis by Using the Nanostring Technology [PDF]
, 2015 Background: Clinical decision and patient care management in inflammatory bowel diseases is largely based on the assessment of clinical symptoms, while the biomarkers currently in use poorly reflect the actual disease activity.
Alexandra Touroutoglou +31 more
core +1 more source
Journal of Thrombosis and Haemostasis, 2015 Epidemiologic studies have revealed that modification of the levels of individual components of the hemostatic system may have effects on the development of thrombosis or hemorrhage. To maintain the necessary equilibrium, the hemostatic system is finely regulated.
Teruel-Montoya, R. +2 more
openaire +4 more sources
Regulation of neutrophil senescence by microRNAs [PDF]
, 2011 Neutrophils are rapidly recruited to sites of tissue injury or infection, where they protect against invading pathogens. Neutrophil functions are limited by a process of neutrophil senescence, which renders the cells unable to respond to chemoattractants,
A Bonauer +60 more
core +4 more sources
Argonaute—a database for gene regulation by mammalian microRNAs
BMC Bioinformatics, 2005 BackgroundThe Sulston score is a well-established, though approximate metric for probabilistically evaluating postulated clone overlaps in DNA fingerprint mapping.
Priyanka Shahi +9 more
semanticscholar +1 more source
Exosome-delivered microRNAs promote IFN-α secretion by human plasmacytoid DCs via TLR7 [PDF]
, 2018 The excessive production of type I IFNs is a hallmark and a main pathogenic mechanism of many autoimmune diseases, including systemic lupus erythematosus (SLE).
Andreoli, Laura +9 more
core +1 more source
Most mammalian mRNAs are conserved targets of microRNAs.
Genome Research, 2008 MicroRNAs (miRNAs) are small endogenous RNAs that pair to sites in mRNAs to direct post-transcriptional repression. Many sites that match the miRNA seed (nucleotides 2-7), particularly those in 3' untranslated regions (3'UTRs), are preferentially ...
Robin C. Friedman +3 more
semanticscholar +1 more source
Evaluation of the Sensitivity and Specificity of MiRNAs in Discriminating Oral Squamous Cell Carcinoma: A Systematic Review and Meta-analysis [PDF]
International Journal of Scientific Research in Dental and Medical Sciences, 2023 Background and aim: Approximately 90% of all oral malignant tumors are squamous cell carcinomas. This study aims to evaluate the sensitivity and specificity of miRNAs in discriminating oral squamous cell carcinoma.
Ali Salehi +4 more
doaj +1 more source
Influence of sex differences on microRNA gene regulation in disease. [PDF]
, 2014 Sexual dimorphism is observed in most human diseases. The difference in the physiology and genetics between sexes can contribute tremendously to the disease prevalence, severity, and outcome.
Eghbali, Mansoureh, Sharma, Salil
core +1 more source
miRBase: annotating high confidence microRNAs using deep sequencing data
Nucleic Acids Res., 2013 We describe an update of the miRBase database (http://www.mirbase.org/), the primary microRNA sequence repository. The latest miRBase release (v20, June 2013) contains 24 521 microRNA loci from 206 species, processed to produce 30 424 mature microRNA ...
Ana Kozomara, S. Griffiths-Jones
semanticscholar +1 more source
An overview of microRNAs. [PDF]
Advanced Drug Delivery Reviews, 2015 The discovery of the first microRNA (miRNA) over 20 years ago has ushered in a new era in molecular biology. There are now over 2000 miRNAs that have been discovered in humans and it is believed that they collectively regulate one third of the genes in the genome.
S. Hammond
semanticscholar +4 more sources