Results 21 to 30 of about 300,285 (315)
Gene Therapy, 2011 MicroRNAs (miRNAs) provide new therapeutic targets for many diseases, while their myriad roles in development and cellular processes make them fascinating to study. We still do not fully understand the molecular mechanisms by which miRNAs regulate gene expression nor do we know the complete repertoire of mRNAs each miRNA regulates.
Broderick, Jennifer A +1 more
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Cytomegalovirus microRNAs [PDF]
Current Opinion in Virology, 2014 The discovery that animals, plants and DNA viruses encode microRNAs (miRNAs) has transformed our understanding of the regulation of gene expression. miRNAs are ubiquitous small non-coding RNAs that regulate gene expression post-transcriptionally, generally by binding to sites within the 3' untranslated regions (UTR) of messenger RNA (mRNA) transcripts.
Lauren Hook +5 more
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Biological Reviews, 2023 ABSTRACTNeutrophils are considered ‘first‐line defence’ cells as they can be rapidly recruited to the site of the immune response. As key components of non‐specific immune mechanisms, neutrophils use phagocytosis, degranulation, and formation of neutrophil extracellular traps (NETs) to fight pathogens.
Marzena Garley +2 more
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Effect of miRs-17/20 on vasospasm in subarachnoid hemorrhage model of rats
Acta Medica Alanya, 2022 Aim: To investigate the effects of melatonin and miRNA-17/20 administration on vasospasm and vascular damage on the bacillary artery in the Subarachnoid hemorrhage (SAH) model of rats.Methods: Rats were divided into 6 groups: Sham, SAH, SAH+NegmiRNA, SAH+
Ümit Ali Malçok, Başak Büyük
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MicroRNAs as biomarkers in induced metabolic syndrome in rats [PDF]
Iraqi Journal of Veterinary SciencesMetabolic syndrome (Mets), consists of many clinical changes, such as dyslipidemia, obesity, resistance to insulin, and oxidative stress. It is become a global epidemic health problem.
Mutaa A. Al-Hayali +2 more
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Успехи молекулярной онкологии, 2020 The most effective treatment of the hormone-dependent breast cancer is based on the antiestrogens SERM and aromatase inhibitor treatment, however its efficiency is limited by the acquired resistance to the drugs.Previously we have revealed the effect of ...
D. V. Sorokin +6 more
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The Role of HSA21 Encoded Mirna in Down Syndrome Pathophysiology:Opportunities in miRNA-Targeted Pharmacotherapy and Diagnosis of the Down Syndrome [PDF]
Pharmaceutical Sciences, 2021 Trisomy 21 is the most prevalent aneuploidy disorder among live-born children worldwide. Itresults from the presence of an extra copy of chromosome 21 which leads to a wide spectrum ofpathophysiological abnormalities and intellectual disabilities ...
Shabnam Mahernia +3 more
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Bioinformatics study of the role of micro RNAs bta-mir-146a, bta-mir-223, bta-mir 21-5p, bta-mir-181 and bta-mir-16a in the cellular signaling pathways of mastitis in dairy cows [PDF]
مجله بیوتکنولوژی کشاورزی, 2019 Objective It is reasonable to investigate the signaling pathways in diseases such as mastitis in dairy cattle, which are more likely to be affected by epigenetics.
مصطفی قادری +4 more
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Cells, 2022 Firstly, I apologize for the delayed publication of this Special Issue in the form of a book title [...]
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Journal of Research in Medical Sciences, 2020 Background: Type 2 diabetes mellitus (T2DM) is a metabolic disorder with growing prevalence and increasing economic burden. Based on the role of genetics and epigenetic factors on T2DM, we aimed to carry a systematic review and meta-analysis for all ...
Morteza Gholami +7 more
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