Results 71 to 80 of about 300,285 (315)

Association of miR-132 and miR-185 Genes Methylation and their Expression Profile with Risk of Congenital Factor XIII Deficiency [PDF]

Journal of Cell and Molecular Research, 2015
Congenital factor XIII deficiency is a very rare bleeding disorder, but because of the high rate of consanguineous marriages, it is common in Sistan and Baluchestan Province of Iran.
Dor Mohammad Kordi-Tamandani, Zohreh Rezaei, Akbar Dorgalaleh-Mail   +2 more
doaj   +1 more source

Domain associated with zinc fingers‐containing NF90‐NF45 complex inhibits m6A modification of primary microRNA by suppressing METTL3/14 activity

FEBS Open Bio, EarlyView.
NF90–NF45 functions as a negative regulator of methyltransferase‐like 3/14 (METTL3/14)‐mediated N6‐methyladenosine (m6A) modification on primary microRNAs (pri‐miRNAs). NF90–NF45 binds to anti‐oncogenic pri‐miRNAs and inhibits their m6A modification, thereby suppressing the biogenesis of anti‐oncogenic miRNAs.
Takuma Higuchi, Shunsuke Morioka, Keiko Morisawa, Kazutsugu Matsukawa, Shingo Ashida, Takeshi Suzuki, Shuji Sakamoto   +6 more
wiley   +1 more source

Urine transcriptomic profile in terms of malignant ovarian tumors

Южно-Российский онкологический журнал
Purpose of the study. Bioinformatic search for transcriptomic markers (based on metabolomic data) and their validation in the urine of serous ovarian adenocarcinoma patients.Materials and methods.
D. S. Kutilin, F. E. Filippov, N. V. Porhanova, A. Yu. Maksimov   +3 more
doaj   +1 more source

Magnesium Oxide nanoparticle effect on the growth, development, and microRNAs expression of Ananas comosus var. bracteatus

Journal of Plant Interactions, 2021
The use of nanoparticles in the appropriate portion to increase plant growth and development is an ongoing biological process. However, its exposure in an inconsiderable proportion become stressful and plant uses diverse regulatory mechanisms such as ...
Mark Owusu Adjei, Xuzixin Zhou, Meiqin Mao, Yanbin Xue, Jiawen Liu, Hao Hu, Jiaheng Luo, Huiling Zhang, Wei Yang, Lijun Feng, Jun Ma   +10 more
doaj   +1 more source

The Aging Blood: Cellular Origins, Circulating Drivers, and Therapeutic Potential

Aging and Cancer, EarlyView.
As a conduit linking all organs, the blood system both reflects and actively drives systemic aging. This review highlights how circulating pro‐aging and antiaging factors and age‐associated hematopoietic stem cell dysfunction contribute to immunosenescence and multi‐organ decline, positioning the hematopoietic system as a target for aging intervention.
Hanqing He, Jianwei Wang
wiley   +1 more source

The Effect of Sialic Acid on MiR-320a and Let-7e Expression in Human Glial Cell Line

Basic and Clinical Neuroscience, 2022
Introduction: Sialic acid is pivotal in various critical physiological events at molecular and cellular levels and pathological processes. Changes in sialic acid concentration are observed in many pathological processes; for example, some available data ...
Negar Noorbakhsh, Hamid Galehdari, Mohammad Shafiei   +2 more
doaj  

The growing relevance of microRNAs as a diagnostic marker for breast cancer [PDF]

, 2023
D. Moher, Frank Mosby, Lisa V. Smith
openalex   +1 more source

Decreased Serum 5‐HT: Clinical Correlates and Regulatory Role in NMJ of MG

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Although 5‐Hydroxytryptamine (5‐HT) indirectly stimulates muscle contraction and participates in regulating Acetylcholine receptor (AChR) cluster homeostasis in cellular, animal, and clinical studies, evidence regarding its potential to modulate muscle contraction in myasthenia gravis (MG) remains limited.
Xinru Shen, Jing Zhang, Xinyue Zhou, Xiaoxiao Yu, Haodong Shang, Shufan Chen, Lulu Zhen, Jinru Wu, Guanlian Hu, Xiaoyan Zhu, Zhan Sun, Yiren Wang, Jiahui Wang, Jie Lv, Xue Zhao, Yingna Zhang, Wei Guo, Ying Peng, Feng Gao   +18 more
wiley   +1 more source

The complex effects of miR-146a in the pathogenesis of Alzheimer’s disease

Neural Regeneration Research
Alzheimer’s disease is a neurodegenerative disorder characterized by cognitive dysfunction and behavioral abnormalities. Neuroinflammatory plaques formed through the extracellular deposition of amyloid-β proteins, as well as neurofibrillary tangles ...
Yunfan Long, Jiajia Liu, Yu Wang, Haidong Guo, Guohong Cui   +4 more
doaj   +1 more source

Inflammation-related microRNAs are involved in stressful life events exposure and in trauma-focused psychotherapy in treatment-resistant depressed patients

European Journal of Psychotraumatology, 2021
Background: About 30% of major depressive disorder (MDD) patients are classified as resistant to treatment (treatment-resistant depression, TRD). Among the factors associated with unfavourable treatment outcomes, stressful life events play a relevant ...
Elisabetta Maffioletti, Luisella Bocchio-Chiavetto, Giulia Perusi, Rosana Carvalho Silva, Chiara Sacco, Roberta Bazzanella, Elisa Zampieri, Marco Bortolomasi, Massimo Gennarelli, Alessandra Minelli   +9 more
doaj   +1 more source