Results 61 to 70 of about 73,898 (290)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Expansion of the Fundamental Diagram from a Microscopic Multilane Modeling Framework of Mixed Traffic

Journal of Advanced Transportation, 2020
Microscopic modeling of mixed traffic (i.e., automaton-driven vehicles and human-driven vehicles) dynamics, particularly car-following, lane-changing, and gap-acceptance, provides the opportunity to gain a more accurate estimation of flow-density ...
Mudasser Seraj, Jiangchen Li, Tony Z. Qiu   +2 more
doaj   +1 more source

Traffic signal control using queueing theory [PDF]

, 2018
Traffic signal control has drawn considerable attention in the literatures thanks to its ability to improve the mobility of urban networks. Queueing models are capable of capturing performance or effectiveness of a queueing system. In this report, SOCPs (
Liu, Hao
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

A Traffic Flow Simulation Framework for Learning Driver Heterogeneity from Naturalistic Driving Data using Autoencoders

International Journal of Automotive Engineering, 2019
This paper proposes a novel data-centric framework for microscopic traffic flow simulation with intra and inter driver heterogeneity. We utilized a naturalistic driving corpus of 46 different drivers to learn and model the behavior divergence of Japanese
Ekim Yurtsever, Chiyomi Miyajima, Kazuya Takeda   +2 more
doaj   +1 more source

Towards a realistic microscopic description of highway traffic

, 2000
Simple cellular automata models are able to reproduce the basic properties of highway traffic. The comparison with empirical data for microscopic quantities requires a more detailed description of the elementary dynamics.
A Schadschneider, Barrett C L, Bureau of Public Roads, Chowdhury D, Edie L C, Esser J, George H P, Helbing D, Institute of Transportation Engineers, Kerner B S, Kerner B S, Kerner B S, Knospe W, L Santen, M Schreckenberg, Miller A J, Nagel K, Nagel K, Pfefer R C, Schlums J, Schreckenberg M, W Knospe, Wolf D E   +22 more
core   +1 more source

A high resolution spatiotemporal model for in-vehicle black carbon exposure : quantifying the in-vehicle exposure reduction due to the Euro 5 particulate matter standard legislation [PDF]

, 2017
Several studies have shown that a significant amount of daily air pollution exposure is inhaled during trips. In this study, car drivers assessed their own black carbon exposure under real-life conditions (223 h of data from 2013).
Dekoninck, Luc, Int Panis, Luc
core   +2 more sources

Consistency of Microscopic Traffic Domain Models

, 2020
Verkehrsingenieure modellieren Verkehr auf verschiedenen Abstraktionsebenen, je nachdem, welche Aspekte von Verkehr betrachtet werden. In der Verkehrstechnik werden meist Modelle verwendet, mit denen die Qualität des Verkehrsablaufs vorhergesagt werden soll.
openaire   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

A Modified Cellular Automaton Model for Accounting for Traffic Behaviors during Signal Change Intervals

Journal of Advanced Transportation, 2018
Previous cellular automata (CA) models have been developed for simulating driver behaviors in response to traffic signal control. However, driver behaviors during traffic signal change intervals, including cross/stop decision and speed adjustment, have ...
Chih-Cheng Hsu, Yu-Chiun Chiou
doaj   +1 more source