Results 61 to 70 of about 13,370 (299)

Microscopic traffic models, accidents, and insurance losses

ASTIN Bulletin
AbstractThe paper develops a methodology to enable microscopic models of transportation systems to be accessible for a statistical study of traffic accidents. Our approach is intended to permit an understanding not only of historical losses but also of incidents that may occur in altered, potential future systems. Through such a counterfactual analysis,
Sojung Kim, Marcel Kleiber, Stefan Weber
openaire   +2 more sources

Fluid-dynamical and microscopic description of traffic flow: a data-driven comparison

, 2010
A lot of work has been done to compare traffic flow models with reality; so far, this has been done separately for microscopic as well as for fluid-dynamical models of traffic flow. This paper compares directly the performance of both types of models
Wagner, Peter, Peter Wagner
core   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Expansion of the Fundamental Diagram from a Microscopic Multilane Modeling Framework of Mixed Traffic

Journal of Advanced Transportation, 2020
Microscopic modeling of mixed traffic (i.e., automaton-driven vehicles and human-driven vehicles) dynamics, particularly car-following, lane-changing, and gap-acceptance, provides the opportunity to gain a more accurate estimation of flow-density ...
Mudasser Seraj, Jiangchen Li, Tony Z. Qiu   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

A Modified Cellular Automaton Model for Accounting for Traffic Behaviors during Signal Change Intervals

Journal of Advanced Transportation, 2018
Previous cellular automata (CA) models have been developed for simulating driver behaviors in response to traffic signal control. However, driver behaviors during traffic signal change intervals, including cross/stop decision and speed adjustment, have ...
Chih-Cheng Hsu, Yu-Chiun Chiou
doaj   +1 more source

Microscopic Co-Simulation Model of Traffic Flow and Carbon Emission for Real-Time Signal Control Strategy Evaluation [PDF]

Jisuanji gongcheng
Real-time simulation and evaluation of carbon reduction effects of signal control strategies is a necessary prerequisite for strategy optimization. In existing studies, carbon emission calculation models that do not couple with traffic simulation or only
HE Zhaocheng, LIU Qin, ZHU Yiting
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Creating Infrastructure for Urban Mobility: Case Study of Skopje

Promet (Zagreb), 2018
In this paper, a methodology for creating and testing new proposed transport infrastructure is presented. It is based on microscopic traffic simulation of current and forecasted traffic demand and in-depth analysis of traffic flow.
Daniela Koltovska Nečoska, Edouard Ivanjko, Daniel Pavleski   +2 more
doaj   +1 more source