Results 131 to 140 of about 26,828 (241)

Radiation inactivation analysis of acyl-CoA:retinol acyltransferase and lecithin:retinol acyltransferase in rat liver

Journal of Lipid Research, 1993
Microsomes from liver and several other tissues esterify retinol through both fatty acyl-CoA-dependent and -independent reactions. Two activities, acyl-CoA:retinol acyltransferase (ARAT) and lecithin:retinol acyltransferase (LRAT) activities, have been ...
AC Ross, ES Kempner
doaj  

Implications for soluble iron accumulation, oxidative stress, and glial glutamate release in motor neuron death associated with sporadic amyotrophic lateral sclerosis

Neuropathology, EarlyView.
Oxidative stress in sporadic amyotrophic lateral sclerosis (ALS) has been evidenced by accumulation of oxidatively modified products of nucleic acids, lipids, sugars, and proteins in the motor neuron system of brains and spinal cords obtained at autopsy from the patients.
Noriyuki Shibata, Ikuko Kataoka, Yukinori Okamura, Kumiko Murakami, Yoichiro Kato, Tomoko Yamamoto, Kenta Masui   +6 more
wiley   +1 more source

Activatable Photosensitizers: From Fundamental Principles to Advanced Designs

Angewandte Chemie, Volume 137, Issue 15, April 7, 2025.
Basic concepts of designing activatable photosensitizers are established in this Review by closely examining quenching mechanisms and bioresponsive constructs essential for their function. New strategies developed in the last five years that address the shortcomings of conventional activatable photosensitizers and which enhance selectivity are also ...
Nahyun Kwon, Hanyi Weng, Maneesha A. Rajora, Gang Zheng   +3 more
wiley   +2 more sources

Towards Real-time Intrahepatic Vessel Identification in Intraoperative Ultrasound-Guided Liver Surgery [PDF]

MICCAI 2024, Oct 2024, Marrakech, Morocco
While laparoscopic liver resection is less prone to complications and maintains patient outcomes compared to traditional open surgery, its complexity hinders widespread adoption due to challenges in representing the liver's internal structure. Laparoscopic intraoperative ultrasound offers efficient, cost-effective and radiation-free guidance.
arxiv  

Genotoxic Herbicide Exposures in Golden Retrievers With and Without Multicentric Lymphoma

Veterinary and Comparative Oncology, EarlyView.
ABSTRACT Canine multicentric lymphoma (CML) is one of the most common malignancies in dogs. Although breed risk is important, environmental factors such as herbicides have also been implicated. The objective of this study was to determine whether genotoxic exposures to the herbicides 2,4‐D and glyphosate are associated with CML, using dogs from the ...
Ashleigh N. Tindle, Lauren M. Krueger, Brenna Swafford, Erin Mani, Camille Danielson, Julia Labadie, Lauren A. Trepanier   +6 more
wiley   +1 more source

The ins and outs of liver fat metabolism: The effect of phenotype and diet on risk of intrahepatic triglyceride accumulation

Experimental Physiology, EarlyView.
Abstract In health, the liver is a metabolically flexible organ that plays a key role in regulating systemic lipid and glucose concentrations. There is a constant flux of fatty acids (FAs) to the liver from multiple sources, including adipose tissue, dietary, endogenously synthesized from non‐lipid precursors, intrahepatic lipid droplets and recycling ...
Kieran Smith, Kaitlyn M. J. H. Dennis, Leanne Hodson   +2 more
wiley   +1 more source

Preclinical Pharmacokinetic Assessment of a Promising Vasorelaxant, Analgesic, and Anti‐Inflammatory Prototype 5‐[1‐(4‐Fluorophenyl)‐1H‐pyrazol‐4‐yl]‐2H‐tetrazole (LQFM020) Through Selective Bioanalytical HPLC‐PDA‐Based Method

Biomedical Chromatography, Volume 39, Issue 5, May 2025.
ABSTRACT A simple and selective high‐performance liquid chromatography bioanalytical method was developed and validated to determine the pharmacokinetic parameters of 5‐[1‐(4‐fluorophenyl)‐1H‐pyrazol‐4‐yl]‐2H‐tetrazole (LQFM020) with promising vasorelaxant, anti‐inflammatory, and antinociceptive properties while verifying its potential hepatic enzyme ...
Lanussy Porfiro de Oliveira, Jerônimo Raimundo de Oliveira Neto, Thiago Sardinha de Oliveira, Lara Marques Naves, Stefanne Madalena Marques, Alessandro Carvalho Cruz, James Oluwagbamigbe Fajemiroye, Gustavo Pedrino, Luciano Morais Lião, Ricardo Menegatti, Luiz Carlos da Cunha   +10 more
wiley   +1 more source

CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption.

Journal of Lipid Research, 1989
CL 277,082 (I) was found to be a potent inhibitor of acyl CoA:cholesterol acyltransferase (ACAT, EC 2.3.1.26) in microsomes from a variety of tissues with IC50 values of 0.14 microM for intestinal mucosal microsomes, 0.74 microM for liver, and 1.18 ...
E E Largis, C H Wang, V G DeVries, S A Schaffer   +3 more
doaj  

Transgenerational Reproductive and Developmental Toxicity Induced by N‐Nitrosodimethylamine and Its Metabolite Formaldehyde in Drosophila melanogaster

Journal of Applied Toxicology, Volume 45, Issue 5, Page 841-857, May 2025.
ABSTRACT N‐Nitrosodimethylamine (NDMA) is a known water disinfection byproduct (DBP) characterized as a potent hepatotoxin, promutagen, and probable human carcinogen; this is because of the metabolites associated with its biotransformation. The metabolism of NDMA produces formaldehyde, another alkylating agent and DBP. Both compounds are generated from
Oscar Eduardo Tabares‐Mosquera, Javier Andrés Juárez‐Díaz, Rafael Camacho‐Carranza, Patricia Ramos‐Morales   +3 more
wiley   +1 more source

Dependence of microsomal lipid synthesis on added protein

Journal of Lipid Research, 1964
Lipid synthesis by rat liver microsomes from l-α-glycerophosphate-1-C14 in the presence of palmitic acid, ATP, CoA, and Mg2+ came to a standstill after 30 min while enough cofactors were still present to promote further synthesis.
Ruth Tzur, B. Shapiro
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