Results 151 to 160 of about 26,828 (241)

A preliminary exploration of liver microsomes and PBPK to uncover the impact of CYP3A4/5 and CYP2C19 on tacrolimus and voriconazole drug-drug interactions. [PDF]

Sci Rep
Zhao YC, Zhang YK, Gao W, Liu HY, Xiao CL, Hou JJ, Li JK, Zhang BK, Xiang DX, Sandaradura I, Yan M.   +10 more
europepmc   +1 more source

The Role of Cholesterol Metabolism and Its Regulation in Tumor Development

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Background Within the tumor microenvironment, tumor cells undergo metabolic reprogramming of cholesterol due to intrinsic cellular alterations and changes in the extracellular milieu. Furthermore, cholesterol reprogramming within this microenvironment influences the immune landscape of tumors, facilitating immune evasion and consequently ...
Yongmei Wu, Wenqian Song, Min Su, Jing He, Rong Hu, Youbo Zhao   +5 more
wiley   +1 more source

Typical and atypical metabolic characteristics of three iridaceae isoflavone components: in vitro and in silico studies. [PDF]

Front Pharmacol
Gu J, Zhang H, Wang M, Zhou Y, Deng Z, Shi R.   +5 more
europepmc   +1 more source

Prediction of SPT-07A Pharmacokinetics in Rats, Dogs, and Humans Using a Physiologically-Based Pharmacokinetic Model and In Vitro Data. [PDF]

Pharmaceutics
Zhu X, Kong W, Wang Z, Liu X, Liu L.
europepmc   +1 more source

Chemical Composition, Edible Safety, and Antioxidant Activity Evaluation of Flowers in a Medicinal Plant Dendrobium chrysotoxum

Food Science &Nutrition, Volume 13, Issue 4, April 2025.
This manuscript presents an analysis of heavy metals and pesticide residues in 49 samples of Dendrobium chrysotoxum flowers collected from five provinces in southern China. A randomly selected sample of D. chrysotoxum underwent a systematic toxicological safety assessment, including an analysis of its chemical composition and an evaluation of its ...
Xu Susu, Li Jinwei, Pu Ran, Xiong Wenyan, Guan Yanhui, Ma Suyun, Liang Zhengwei, Zhang Jingli, Chen Junwen   +8 more
wiley   +1 more source

Exploring the Impact of Pharmaceutical Excipient PEG400 on the Pharmacokinetics of Mycophenolic Acid Through In Vitro and In Vivo Experiments. [PDF]

Int J Mol Sci
Li C, Zhang M, Zhao Y, Yang D, Zhao M, Shang L, Sun X, Zhang S, Wang P, Gao X.   +9 more
europepmc   +1 more source

Exploring the Utility of Prunus mahaleb Extracts as a Source of Natural Bioactive Compounds for Functional Applications

Food Science &Nutrition, Volume 13, Issue 4, April 2025.
Our findings indicate that P. mahaleb can serve as a versatile raw material for the development of health‐promoting applications, including medicines, cosmeceuticals, and nutraceuticals. ABSTRACT Prunus mahaleb has garnered attention as a potent medicinal agent and functional component.
Bayram Atasagun, Ahmet Uysal, Noha Fathallah, Omayma Eldahshan, Abdel Nasser Singab, Mehmet Veyis Cetiz, Gokhan Zengin   +6 more
wiley   +1 more source

Identification of a Series Containing a Pentafluorophenyl Moiety That Targets Pks13 to Inhibit Growth of <i>Mycobacterium tuberculosis</i>. [PDF]

ACS Infect Dis
Green SR, Harrison JR, Thompson S, Murugesan D, Libardo MDJ, Engelhart CA, Meshanni J, Fletcher D, Scullion P, Edwards D, Epemolu O, Mutter N, Shishikura Y, Riley J, Ioerger TR, Roca Guillén JJ, López LG, Read KD, Barry CE, Schnappinger D, Wyatt PG, Boshoff HIM, Cleghorn LAT.   +22 more
europepmc   +1 more source

Elucidating Contributions of Drug Transporters/Enzyme to Nonlinear Pharmacokinetics of Grazoprevir by PBPK Modeling With a Cluster Gauss–Newton Method

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 4, Page 770-780, April 2025.
ABSTRACT Grazoprevir (GZR), a direct‐acting agent for hepatitis C virus, is recognized as a substrate for organic anion transporting polypeptide 1B (OATP1B), cytochrome P450 3A (CYP3A), and P‐glycoprotein (P‐gp). The objective of the present study was to elucidate the contribution of these molecules to the nonlinear pharmacokinetics of GZR using a ...
Takashi Yoshikado, Yasunori Aoki, Ryo Nakamura, Saeko Shida, Yuichi Sugiyama, Koji Chiba   +5 more
wiley   +1 more source

Primary versus secondary recurrent pregnancy losses: Clinical findings and live birth rate after comprehensive work‐up and personalized management

Acta Obstetricia et Gynecologica Scandinavica, Volume 104, Issue 4, Page 697-706, April 2025.
Recurrent pregnancy loss (RPL) is a heterogeneous multifactorial syndrome. A customized management can lead to a good pregnancy outcome in more than a half of cases. Age <40 and AMH >1 ng/mL are the major positive predictors of live birth rate in RPL women.
Chiara Tersigni, Marianna Onori, Giuliana Beneduce, Fabio Sannino, Rita Franco, Andrea Busnelli, Chiara Granieri, Domenico Milardi, Alfredo Pontecorvi, Antonio Lanzone, Giovanni Scambia, Nicoletta Di Simone   +11 more
wiley   +1 more source