Results 181 to 190 of about 1,648,763 (279)

Chemical profiling and characterisation of anthraquinone‐based polyphenols as biocolourants from Cortinarius semisanguineus

Coloration Technology, EarlyView.
Abstract Anthraquinone dyes are known for their significant colour (brightness of shade in the red, blue and green areas) and light fastness properties compared with other synthetic dyes (such as azo‐based dyes). However, challenging multi‐step synthesis of anthraquinones and limited access to fewer substituents result in insufficient reactivity ...
Arvind Negi, Peppi Toukola, Riikka Räisänen   +2 more
wiley   +1 more source

Bridging the gap in obesity research: A consensus statement from the European Society for Clinical Investigation

European Journal of Clinical Investigation, EarlyView.
This consensus highlights critical research gaps in obesity epidemiology, phenotypic heterogeneity and clinical management, calling for advanced methodologies, collaborative strategies and innovative policies to mitigate the global obesity epidemic and its socio‐economic impacts.
Federico Carbone, Jean‐Pierre Després, John P. A. Ioannidis, Ian J. Neeland, Gabriella Garruti, Luca Busetto, Luca Liberale, Stefano Ministrini, Gemma Vilahur, Thomas H. Schindler, Maria Paula Macedo, Agostino Di Ciaula, Marcin Krawczyk, Andreas Geier, Gyorgy Baffy, Maria Felicia Faienza, Ilaria Farella, Nicola Santoro, Gema Frühbeck, Patricia Yárnoz‐Esquiroz, Javier Gómez‐Ambrosi, Emma Chávez‐Manzanera, Verónica Vázquez‐Velázquez, Jean‐Michel Oppert, Dimitrios N. Kiortsis, Paolo Sbraccia, Carmine Zoccali, Piero Portincasa, Fabrizio Montecucco   +28 more
wiley   +1 more source

CL 277,082: a novel inhibitor of ACAT-catalyzed cholesterol esterification and cholesterol absorption.

Journal of Lipid Research, 1989
CL 277,082 (I) was found to be a potent inhibitor of acyl CoA:cholesterol acyltransferase (ACAT, EC 2.3.1.26) in microsomes from a variety of tissues with IC50 values of 0.14 microM for intestinal mucosal microsomes, 0.74 microM for liver, and 1.18 ...
E E Largis, C H Wang, V G DeVries, S A Schaffer   +3 more
doaj  

A review of the putative antiseizure and antiepileptogenic mechanisms of action for soticlestat

Epilepsia, EarlyView.
Abstract Soticlestat (TAK‐935) is a potent and selective inhibitor of cholesterol 24‐hydroxylase (CYP46A1), an enzyme primarily expressed in the brain that catabolizes cholesterol to 24S‐hydroxycholesterol (24HC). In the ELEKTRA phase II clinical trial, soticlestat reduced seizure frequency in patients with developmental and epileptic encephalopathies,
Shinichi Kondo, Venkatesha Murthy, Mahnaz Asgharnejad, Arturo Benitez, Kosuke Nakashima, Nicole Hawkins, H. Steve White   +6 more
wiley   +1 more source

Dependence of microsomal lipid synthesis on added protein

Journal of Lipid Research, 1964
Lipid synthesis by rat liver microsomes from l-α-glycerophosphate-1-C14 in the presence of palmitic acid, ATP, CoA, and Mg2+ came to a standstill after 30 min while enough cofactors were still present to promote further synthesis.
Ruth Tzur, B. Shapiro
doaj  

PI5P4K inhibitors: promising opportunities and challenges

The FEBS Journal, EarlyView.
Developing inhibitors is like climbing a steep, challenging mountain. PI5P4K inhibitors hold significant promise for the treatment of cancer, immune disorders, and neurological diseases. However, the path to success is fraught with hurdles, and researchers are therefore required to apply their expertise to overcome critical “checkpoints.” While some ...
Koh Takeuchi, Lisa Nagase, Shun Kageyama, Hirotaka Kanoh, Masashi Oshima, Aki Ogawa‐Iio, Yoshiki Ikeda, Yuki Fujii, Sei Kondo, Natsuki Osaka, Takeshi Masuda, Tsukasa Ishihara, Yoshikazu Nakamura, Yoshihisa Hirota, Takehiko Sasaki, Toshiya Senda, Atsuo T. Sasaki   +16 more
wiley   +1 more source

Sterol carrier protein2-like activity in rat intestine.

Journal of Lipid Research, 1988
A sterol carrier protein2 (SCP2)-like activity has been demonstrated in rat intestinal mucosal homogenates and in isolated intestinal cells from both crypt and villus zones. The results indicate the presence of a protein with similar molecular weight and
A Kharroubi, J A Wadsworth, R Chanderbhan, P Wiesenfeld, B Noland, T Scallen, G V Vahouny, L L Gallo   +7 more
doaj  

An adamantane‐based ligand as a novel chemical tool for thermosensory TRPM8 channel therapeutic modulation

The FEBS Journal, EarlyView.
Transient receptor potential cation channel subfamily M member 8 (TRPM8) is a cationic thermosensory channel crucial for cold sensation and menthol response. TRPM8 dysfunction leads to sensory symptoms such as cold allodynia. Targeting TRPM8 is important for treating diseases like peripheral neuropathies and cancer.
Angela Lamberti, Silvio Aprile, David Cabañero, Fabio Travagin, Laura Butron, Gregorio Fernández‐Ballester, Gian Cesare Tron, Asia Fernández‐Carvajal, Antonio Ferrer‐Montiel, Ubaldina Galli   +9 more
wiley   +1 more source

Current insights into pathogenesis and anti‐inflammatory treatment strategies for severe alcohol‐associated hepatitis: focus on neutrophil‐targeted therapies

Hepatology Research, EarlyView.
Abstract Alcohol‐associated hepatitis (AH) is the leading cause of liver‐related mortality, with severe alcohol‐associated hepatitis (SAH) showing a short‐term mortality rate of 20%–50% even in developed countries. Corticosteroids are the only evidence‐based pharmacologic treatment, but their efficacy is limited to short‐term survival, with 30%–40% of ...
Ryosuke Kasuga, Po‐Sung Chu, Takanori Kanai, Nobuhiro Nakamoto   +3 more
wiley   +1 more source

Nicotine oxidation by genetic variants of CYP2B6 and in human brain microsomes [PDF]

, 2019
Bloom, Adam Joseph, Kharasch, Evan D, Wang, Pan-Fen   +2 more
core   +2 more sources