Results 41 to 50 of about 1,685,497 (299)
Mass spectrometry in ocular drug research
Mass Spectrometry Reviews, EarlyView., 2023 Abstract Mass spectrometry (MS) has been proven as an excellent tool in ocular drug research allowing analyzes from small samples and low concentrations. This review begins with a short introduction to eye physiology and ocular pharmacokinetics and the relevance of advancing ophthalmic treatments.
Eva M. del Amo +6 more
wiley +1 more source
Pharmaceutics, 2021 DN203368 ((E)-3-[1-(4-[4-isopropylpiperazine-1-yl]phenyl) 3-methyl-2-phenylbut-1-en-1-yl] phenol) is a 4-hydroxy tamoxifen analog that is a dual inverse agonist of estrogen-related receptor β/γ (ERRβ/γ).
Sin-Eun Kim +13 more
doaj +1 more source
Journal of Pharmacy & Pharmaceutical Sciences, 2007 Purpose. The selective monoamine oxidase-B (MAO-B) inhibitor, l-deprenyl, is still used for treating Parkinson's patients, however, a disadvantage of its use lies in the formation of l-amphetamine and l-methamphetamine.
Stefania Dragoni +7 more
doaj +1 more source
Molecular Pharmaceutics, 2010 The present study aims to predict the regiospecific glucuronidation of three dihydroxyflavones and seven monohydroxyflavones in human liver and intestinal microsomes using recombinant UGT isoforms. Seven monohydroxyflavones (or HFs), 2'-, 3'-, 4'-, 3-, 5-
Lan Tang +7 more
semanticscholar +1 more source
World Journal of Traditional Chinese Medicine, 2018 Objective: Anthraquinone (AQ), a major bioactive component of the traditional Chinese medicine HeShouWu, has widespread applications in industry and medicine.
Sha Chen +6 more
doaj +1 more source
A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response [PDF]
, 2008 The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are closely related orphan nuclear hormone receptors that play a critical role as xenobiotic sensors in mammals.
Anja Rode +19 more
core +3 more sources
Über den Steringehalt pflanzlicher Mikrosomen
CHIMIA, 1975 The composition of microsomal lipids from Spirodela oligorrhiza L., Lactuca sativa L., and Allium porrum L. plants was investigated. Contamination by chloroplast lipids was calculated and eliminated, giving the lipids of “chloroplast-free microsomes ...
W. Eichenberger
doaj +1 more source
Decavanadate displaces inositol 1,4,5-trisphosphate (IP3) from its receptor and inhibits IP3 induced Ca2+ release in permeabilized pancreatic acinar cells [PDF]
, 1991 Inositol 1,4,5-trisphosphate (IP3) induced Ca2+ release in digitonin permeabilized rat pancreatic acinar cells is specifically inhibited by decavanadate.
Ammann +30 more
core +1 more source
Nucleotide Activation of Liver Microsomal Glucuronidation
Journal of Biological Chemistry, 1961 6 páginas en ...
Pogell, Burton M., Leloir, Luis Federico
openaire +3 more sources
In vivo and in vitro assessment of mirtazapine pharmacokinetics in cats with liver disease. [PDF]
, 2018 BackgroundLiver disease (LD) prolongs mirtazapine half-life in humans, but it is unknown if this occurs in cats with LD and healthy cats.Hypothesis/objectivesTo determine pharmacokinetics of administered orally mirtazapine in vivo and in vitro (liver ...
Benson, Kellyi K +6 more
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