Results 41 to 50 of about 64,891 (274)
Journal of Lipid Research, 1984 The influence of membrane cholesterol content on 3-hydroxy-3-methylglutaryl CoA reductase (HMG-CoA reductase, EC 1.1.1.34) in rat liver microsomes was investigated.
G P van Heusden, K W Wirtz
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Effect of blood plasma lipoproteins on hydroxylation of benzo[a]pyrene in liver microsomes of rats
Атеросклероз, 2020 This work presents the characteristics of the catalytic activity of hydroxylation of benzo[a] pyrene (B[a]P) in rat liver microsomes using plasma lipoproteins (LP) (VLDL, LDL, HDL) as transport forms of B[a]P.
L. M. Polyakov +5 more
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A Human Mass Balance and Metabolism Study of [<sup>14</sup>C]-Ubrogepant in Healthy Male Adults. [PDF]
Clin Pharmacol Drug DevAbstract Ubrogepant is a calcitonin gene–related peptide receptor antagonist approved for the acute treatment of migraine with or without aura in adults. The mass balance and metabolism of ubrogepant was evaluated in six healthy male adults administered a single oral dose of [14C]‐ubrogepant 50 mg (∼200 µCi).
Boinpally RR +13 more
europepmc +2 more sources
Human Liver Microsomal Metabolism of (+)-Discodermolide [PDF]
Journal of Natural Products, 2009 The polyketide natural product (+)-discodermolide is a potent microtubule stabilizer that has generated considerable interest in its synthetic, medicinal, and biological chemistry. It progressed to early clinical oncology trials, where it showed some efficacy in terms of disease stabilization but also some indications of causing pneumotoxicity ...
Yun, Fan +2 more
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UPLC-MS/MS analysis of ochratoxin A metabolites produced by Caco-2 and HepG2 cells in a co-culture system [PDF]
, 2017 Ochatoxin A (OTA) is one of the most important mycotoxins based on its toxicity. The oral route is the main gateway of entry of OTA into the human body, and specialized epithelial cells constitute the first barrier.
González Arias, Cyndia A. +4 more
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Digitoxin metabolism by rat liver microsomes [PDF]
Biochemical Pharmacology, 1975 Background: Malnutrition among hospitalized patients increases length of stay (LOS) and carries extra hospitalization costs. Objective: To review the impact of malnutrition on hospital LOS and costs in Europe. Methods: PubMed and Google Scholar search. All articles from January 2004 until November 2014 were identified.
Schmoldt, A +3 more
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Journal of Pharmacy & Pharmaceutical Sciences, 2007 Purpose. The selective monoamine oxidase-B (MAO-B) inhibitor, l-deprenyl, is still used for treating Parkinson's patients, however, a disadvantage of its use lies in the formation of l-amphetamine and l-methamphetamine.
Stefania Dragoni +7 more
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Pharmaceutics, 2021 DN203368 ((E)-3-[1-(4-[4-isopropylpiperazine-1-yl]phenyl) 3-methyl-2-phenylbut-1-en-1-yl] phenol) is a 4-hydroxy tamoxifen analog that is a dual inverse agonist of estrogen-related receptor β/γ (ERRβ/γ).
Sin-Eun Kim +13 more
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Microsomal superoxide anion production and NADPH-oxidation in a series of 22 aziridinylbenzoquinones [PDF]
, 1989 Several 2,5-bis(1-aziridinyl)-1,4-benzoquinones (BABQs) can be activated to alkylating species by reduction of the quinone moiety. On the other hand, cytotoxicity of these compounds can be induced by redox cycling.
Koster, Andries Sj. +3 more
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Journal of Lipid Research, 1971 Rat and guinea pig liver microsomes labeled with phospholipid 32P were incubated with rat, guinea pig, and rabbit plasma in a KC1–Tris–EDTA buffer. A net transfer of microsomal phosphatidylcholine and phosphatidylethanolamine to plasma was observed.
D.B. ZILVERSMIT
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